Factors associated with changes in creatine phosphokinase (CPK) in trauma patients submitted to the “Red Wave”, with evolution to rhabdomyolysis

Neto, Mario Pastore; Gonçalves, Rafael Valério; Machado, Carla Jorge; Resende, Vívian

doi:10.1590/0100-6991e-20181604

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…All information supposedly lead to the presence of unusual muscular complaint, any suspicious physical tests with odd laboratory values of muscle related enzyme [18,19]. An increased in plasma creatine kinase (CK) level perhaps being a warning for a serious muscular injury condition [20].…”

Section: Pathogenesis Of Malaria Related Rhabdomyolisismentioning

confidence: 99%

Malarial Related Myopathies: A Rhabdomyolysis Story

Siagian

2020

IJPR

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Malaria is amongst the most prevalent and epidemiologically relevant global parasitic protozoan infections. It is infecting millions of people annually, especially in south east Asia and sub Saharan Africa. Its morbidity and mortality still cannot be controlled entirely and elimination is still far away. Children and pregnant women are among the most vulnerable group in the population. Its pathobiology have related to cause direct or indirect deleterious effect on the patient’s skeletal muscle, named rhabdomyolysis. Eventhough it is very rare, but potentially fatal and lethal. Three mechanism of malaria related rhabdomyolysis are very intense inflammatory response, extensive red cells sequestration in muscle capillaries due to severe anemia and the parasite toxin’s, will lead to or add risks of complication. Derangement of specific type of muscle, named the skeletal and cardiac, is amongst the earliest sign of severe malaria. Further study need to be conducted in the future, especially on important topics about mechanism and its effect, signaling pathways, best practice on laboratory approach and management strategy best practice.

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Section: Pathogenesis Of Malaria Related Rhabdomyolisismentioning

confidence: 99%