Exploring flow rate selection in HIPEC procedures

Batista, Thales Paulo; Badiglian-Filho, Levon; Leão, Cristiano de Souza

doi:10.1590/0100-69912016006014

Cited by 7 publications

(7 citation statements)

References 5 publications

(2 reference statements)

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“…The use of cisplatin under (H)IPEC is off-label, based on the approved intravenous injection route. Due to the lack of a standard treatment regimen, the current reported (H)IPEC doses of cisplatin range from 50 to as high as 250 mg/m 2 with treatment durations varying from 30 to 120 min (7,(19)(20)(21). Moreover, the pharmacokinetics (PK) and drug responses (i.e., efficacy and toxicity) of cisplatin (H)IPEC dosing, and their potential relationships are poorly understood.…”

Section: Introductionmentioning

confidence: 99%

PKPD Modeling and Dosing Considerations in Advanced Ovarian Cancer Patients Treated with Cisplatin-Based Intraoperative Intraperitoneal Chemotherapy

Xie

Bocxlaer

Colin

et al. 2020

AAPS J

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Intraperitoneal chemoperfusion (IPEC) of cisplatin is a popular treatment for advanced ovarian cancer, typically under hyperthermia (HIPEC). The use of cisplatin under (H)IPEC is off-label, and the role of hyperthermia is unknown. The aim of this study was to characterize the pharmacokinetic/pharmacodynamic (PKPD) properties of cisplatin under (H)IPEC and to predict the optimal treatment regimen. Using a randomized design, data on intact cisplatin perfusate and plasma concentrations, leukocyte counts-a hematotoxicity marker-and serum creatinine-a nephrotoxicity marker-were collected from 50 patients treated with a combination of cytoreductive surgery (CRS) and either normothermic or hyperthermic IPEC of cisplatin dosed at 75, 100, and 120 mg/m 2 . The non-linear mixed effects modeling technique was used to construct the PKPD models. The PK of intact cisplatin was characterized by a two-compartment model. A semi-physiological myelosuppression model for the leukopenia was modified to account for the CRS-induced leukocytosis and the residual myelosuppression effect of neoadjuvant chemotherapy. The incidence and severity of nephrotoxicity were described by a discrete-time Markov model. Hyperthermia increased the absorption rate of cisplatin by 16.3% but did not show a clinically relevant impact on the investigated toxicities compared with normothermia. Leukopenia was not severe, but nephrotoxicity can become severe or life-threatening and was affected by the dose and IPEC duration. The model predicted that nephrotoxicity is minimal at a cisplatin dose of 75 mg/m 2 with an IPEC duration of 1-2 h and an 1-h duration is favored for doses between 100 and 120 mg/m 2 .

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Section: Introductionmentioning

confidence: 99%

PKPD Modeling and Dosing Considerations in Advanced Ovarian Cancer Patients Treated with Cisplatin-Based Intraoperative Intraperitoneal Chemotherapy

Xie

Bocxlaer

Colin

et al. 2020

AAPS J

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“…In regards of flow rate parameters, our purpose is that 300-500mL/min should be applied during the "patientfilling phase" and thus increased to 700mL/min during the "circulation" and "HIPEC" phases [56][57][58] .…”

Section: Proposal For Standardizing Procedures Patients Selectionmentioning

confidence: 99%

A proposal of Brazilian Society of Surgical Oncology (BSSO/SBCO) for standardizing cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) procedures in Brazil: pseudomixoma peritonei, appendiceal tumors and malignant peritoneal mesothelioma

Batista

Sarmento

Loureiro³

et al. 2017

Rev. Col. Bras. Cir.

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Cytoreductive surgery plus hypertermic intraperitoneal chemotherapy has emerged as a major comprehensive treatment of peritoneal malignancies and is currently the standard of care for appendiceal epithelial neoplasms and pseudomyxoma peritonei syndrome as well as malignant peritoneal mesothelioma. Unfortunately, there are some worldwide variations of the cytoreductive surgery and hypertermic intraperitoneal chemotherapy techniques since no single technique has so far demonstrated its superiority over the others. Therefore, standardization of practices might enhance better comparisons between outcomes. In these settings, the Brazilian Society of Surgical Oncology considered it important to present a proposal for standardizing cytoreductive surgery plus hypertermic intraperitoneal chemotherapy procedures in Brazil, with a special focus on producing homogeneous data for the developing Brazilian register for peritoneal surface malignancies.

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“…A Cirurgia tem uma importância fundamental na abordagem terapêutica multidisciplinar. (BATISTA, TP;BADIGLIAN FILHO, L;LEAO, CS, 2016). Pois bons resultados foram obtidos.…”

Section: Introductionunclassified

“…A nutrição parenteral é recomendada para suporte nutricional devido a gastroparesia, exige também que o paciente permaneça com sonda nasoenteral para alimentação até a recuperação total da gastroparesia. (BATISTA, TP; BADIGLIAN FILHO, L;LEAO, CS, 2016).…”

Section: Introductionunclassified

“…Cuidados redobrados são exigidos durante a monitorização dos sinais vitais, avaliação da perfusão periférica, débito cardíaco, pressão venosa central, avaliação da dor devido aos dispositivos, anotação rigorosa dos débitos dos dispositivos e drenos, das características da ferida operatória, balanço hídrico. Por fim, o cuidado humanizado e participativo da equipe multidisciplinar é fundamental para o enfrentamento do câncer (BATISTA, TP;BADIGLIAN FILHO, L;LEAO, CS, 2016).…”

Section: Introductionunclassified

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Incontinência Urinária Em Idosas: Um Olhar a Luz Das Evidências

Ibiapina¹,

Silva²,

Leal³

et al. 2020

Inovação Tecnológica E O Domínio Das Técnicas De Investigação Na Medicina 4

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Exploring flow rate selection in HIPEC procedures

Cited by 7 publications

References 5 publications

PKPD Modeling and Dosing Considerations in Advanced Ovarian Cancer Patients Treated with Cisplatin-Based Intraoperative Intraperitoneal Chemotherapy

PKPD Modeling and Dosing Considerations in Advanced Ovarian Cancer Patients Treated with Cisplatin-Based Intraoperative Intraperitoneal Chemotherapy

A proposal of Brazilian Society of Surgical Oncology (BSSO/SBCO) for standardizing cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) procedures in Brazil: pseudomixoma peritonei, appendiceal tumors and malignant peritoneal mesothelioma

Incontinência Urinária Em Idosas: Um Olhar a Luz Das Evidências

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