Obesity, adiposopathy, and quantitative imaging biomarkers

Yamauchi, Fernando Ide; Castro, Adham do Amaral e

doi:10.1590/0100-3984.2017.50.3e2

Cited by 4 publications

(4 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Adiposopathy is comprised by adipocyte hypertrophy, decreased adipose tissue blood flow, altered oxygen levels within the tissue, a state of chronic low-grade inflammation and blunted lipid metabolism 41,42 . With obesity levels increasing, the risk of premature Type 1 MI is likely continue increasing, with further research needed on the effect of adiposopathy on young subjects 43 .…”

Section: Traditional Risk Factors For MI Type-i In Young Patientsmentioning

confidence: 99%

Risk factors profile of young and older patients with myocardial infarction

Sagris

Antonopoulos

Theofilis

et al. 2021

Cardiovascular Research

View full text Add to dashboard Cite

Myocardial infarction (MI) among young adults (< 45 years) represents a considerable proportion of the total heart attack incidents. The underlying pathophysiologic characteristics, atherosclerotic plaque features and risk factors profile differ between young and older patients with MI. This review article discusses the main differences between the younger and elderly MI patients as well as the different pathogenic mechanisms underlying the development of MI in the younger. Young patients with MI often have eccentric atherosclerotic plaques with inflammatory features but fewer lesions, and are more likely to be smokers, obese, and have poor lifestyle, such as inactivity and alcohol intake. Compared to older MI patients, younger are more likely to be men, have familial-combined hyperlipidemia and increased levels of lipoprotein-a. In addition, MI in younger patients may be related to use of cannabis, cocaine use and androgenic anabolic steroids. Genomic differences especially in the pathways of coagulation and lipid metabolism have also been identified between young and older patients with MI. Better understanding of the risk factors and the anatomic and pathophysiologic processes in young adults can improve MI prevention and treatment strategies in this patient group. Awareness could help identify young subjects at increased risk and guide primary prevention strategies. Additional studies focusing on gene pathways related to lipid metabolism, inflammation and coagulation are needed.

show abstract

Section: Traditional Risk Factors For MI Type-i In Young Patientsmentioning

confidence: 99%

Risk factors profile of young and older patients with myocardial infarction

Sagris

Antonopoulos

Theofilis

et al. 2021

Cardiovascular Research

View full text Add to dashboard Cite

show abstract

“…It has an important role in pro-inflammatory molecule release, such as Interleukin-6 (IL-6), tumor necrosis factor (TNF) alpha and leptin, which act on both local and systemic inflammation conditions 12 . Some patients with obesity suffer from a systemic pro-inflammatory state called adiposopathy, which is associated with the increase for developing multiple diseases 4 , 27 . In the present study, the increase of CRP among patients with AA was seen in the subset of individuals with obesity when correlated to normal or lean BMI.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of C-Reactive Protein and the Influence of Visceral Fat in Patients With Obesity and Acute Appendicitis

Castro

Skare

Yamauchi

et al. 2018

ABCD, arq. bras. cir. dig.

Self Cite

View full text Add to dashboard Cite

Background: The C reactive protein (CRP) is one of the most accurate inflammatory markers in acute appendicitis (AA). Obesity leads to a pro-inflammatory state with increased CRP, which may interfere with the interpretation of this laboratory test in AA. Aim: To assess sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of CRP in patients with AA and their correlation to body mass index (BMI) and body fat composition. Method: This is a retrospective study based on clinical records and imaging studies of 191 subjects with histopathologically confirmed AA compared to 249 controls who underwent abdominal computed tomography (CT). Clinical and epidemiological data, BMI, and CRP values were extracted from medical records. CT scans were assessed for AA findings and body composition measurements. Results: CRP values increased according to patients’ BMI, with varying sensitivity from 79.78% in subjects with normal or lean BMI, 87.87% in overweight, and 93.5% in individuals with obesity. A similar pattern was observed for NPV: an increase with increasing BMI, 69.3% in individuals with normal or lean BMI, 84.3% in overweight, and 91.3% in individuals with obesity. There was a positive correlation between CRP and visceral fat area in patients with AA. Conclusions: Variations exist for sensitivity, specificity, PPV, and NPV values of CRP in patients with AA, stratified by BMI. An increase in visceral fat area is associated with elevated CRP across the BMI spectrum.

show abstract

“…Said, M. A et al noted that a log-additive effect on the risk of developing cardiovascular diseases was present when the health habits and the individual genetic background were considered in a large population [ 60 ]. The American Heart Association (AHA) recently established the concept of the American Heart Association’s Life’s Simple 7 (LS7) metrics based on four healthy behavior metrics (non-smoking, normal weight, moderate physical activity, and a healthy diet) and three health factors (normal cholesterol, blood pressure, and fasting blood glucose [FBG]) [ 61 , 62 ]. Yang, Y. et al and a MESA study showed that the subgroup with 3 to 7 ideal components from the optimal LS7 status had low risk of AF (57~59% reduced risk), while adherence to the optimal LS7 status reduced the risk even more [ 62 , 63 ].…”

Section: Sedentary Lifestylementioning

confidence: 99%

Atrial Fibrillation: Pathogenesis, Predisposing Factors, and Genetics

Sagris

Vardas

Theofilis

et al. 2021

IJMS

116

View full text Add to dashboard Cite

Atrial fibrillation (AF) is the most frequent arrhythmia managed in clinical practice, and it is linked to an increased risk of death, stroke, and peripheral embolism. The Global Burden of Disease shows that the estimated prevalence of AF is up to 33.5 million patients. So far, successful therapeutic techniques have been implemented, with a high health-care cost burden. As a result, identifying modifiable risk factors for AF and suitable preventive measures may play a significant role in enhancing community health and lowering health-care system expenditures. Several mechanisms, including electrical and structural remodeling of atrial tissue, have been proposed to contribute to the development of AF. This review article discusses the predisposing factors in AF including the different pathogenic mechanisms, sedentary lifestyle, and dietary habits, as well as the potential genetic burden.

show abstract

Obesity, adiposopathy, and quantitative imaging biomarkers

Cited by 4 publications

References 14 publications

Risk factors profile of young and older patients with myocardial infarction

Risk factors profile of young and older patients with myocardial infarction

Diagnostic Value of C-Reactive Protein and the Influence of Visceral Fat in Patients With Obesity and Acute Appendicitis

Atrial Fibrillation: Pathogenesis, Predisposing Factors, and Genetics

Contact Info

Product

Resources

About