Intestinal and appendiceal paracoccidioidomycosis

Gava, Priscila; Melo, Alessandro Severo Alves de; Marchiori, Edson; Costa, Márcia Gisele Santos da; Pereira, E; Rangel, Raissa Dantas Batista

doi:10.1590/0100-3984.2014.0035

Cited by 10 publications

(4 citation statements)

References 21 publications

(10 reference statements)

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“…The signs and symptoms presented by the majority of the patients from this cohort were related to the reticuloendothelial system, corresponding to the findings of other authors . Disseminated lethal cases affecting unusual organs and tissues with no clinical evidence were also observed in this study, confirming that the yeasts are capable to invade every tissue of the human body …”

Section: Discussionsupporting

confidence: 90%

“…Albumin levels significantly increased the area under the curve lethal cases affecting unusual organs and tissues with no clinical evidence were also observed in this study, confirming that the yeasts are capable to invade every tissue of the human body. [17][18][19][20][21][22][23][27][28][29][30][31] The extent of the elapsed time since the appearance of the first symptoms of PCM until the admission in a specialised centre did not interfere in the development of complications of the disease.…”

Section: Discussionmentioning

confidence: 99%

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Acute‐subacute paracoccidioidomycosis: A paediatric cohort of 141 patients, exploring clinical characteristics, laboratorial analysis and developing a non‐survival predictor

Romaneli

Tardelli

Tresoldi

et al. 2019

Mycoses

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Summary The acute‐subacute form of paracoccidioidomycosis (PCM) is a severe systemic mycosis that affects children and adolescents from endemic regions, leading to generalised lymphadenopathy, fever, weight loss, anaemia, eosinophilia, hypoalbuminemia and hypergammaglobulinemia. The objective of this study is to describe the clinical and laboratorial characteristics of acute‐subacute PCM, to determine a mortality risk factor and to propose a test for non‐survival hazard related to the disease. Children and adolescents diagnosed with PCM, under 15 years were included in the study. Their epidemiological, clinical and laboratorial data were obtained from the hospital records. Descriptive analysis, comparison of means, univariate logistic regression, multivariate logistic regression and a ROC curve were performed in order to identify significant information (P < .05). Through a period of 38 years, 141 children and adolescents were diagnosed with acute‐subacute PCM. The main antifungal agent used for the treatment was sulfamethoxazole‐trimethoprim (SMX‐TMP). The complication rate was 17%, the relapse rate was 7.8% and the mortality rate was 5.7%. A low albumin dosage was identified as a predictor factor for mortality. The cut‐off for serum albumin was 2.18 g/dL, above which, the survival rate is 99.1%. Thus, simple clinical and laboratorial examinations may lead to the diagnosis of acute‐subacute PCM, and the beginning of the treatment is encouraged even before the isolation of the fungus in biological samples, preventing unfavourable outcomes. Patients with an albumin dosage ≤ 2.18g/dL must receive special attention, preferably hospitalised, during the first four weeks of treatment for presenting an elevated mortality hazard.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Acute‐subacute paracoccidioidomycosis: A paediatric cohort of 141 patients, exploring clinical characteristics, laboratorial analysis and developing a non‐survival predictor

Romaneli

Tardelli

Tresoldi

et al. 2019

Mycoses

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“…The intestinal involvement in PCM can affect the mucosa, submucosa, and lymphatic abdominal system and is more frequently seen in the acute/subacute form [5]. Authors has been suggested that the fungi reach the gastrointestinal mucosa by the hematogenous route from the lungs and mediastinal lymph nodes, either from the primary infection in subacute form patients or from reactivated lesions in chronic form patients [13][14][15][16][17][18][19][20][21][22][23]. Clinical manifestations of intestinal PCM include epigastric pain and diarrhea for several weeks to several months.…”

Section: Discussionmentioning

confidence: 99%

“…When the PCM affects the intestine, all segments can be involved, but predominantly affects the jejunum, terminal ileum, appendix, and proximal portion of the large intestine. Mesenteric ganglion infarction with lymphatic stasis and lymph reflux toward the intestinal lumen was observed in the small and large intestine, leading to an exudative enteropathy [5,13,14]. The hematogenic spread is the main form which PCM reaches any organ, include the intestine, but ingestion may be considered [15].…”

Section: Introductionmentioning

confidence: 99%

Unusual Intestinal Involvement by Paracoccidioidomycosis Diagnosed After Oral Manifestation

et al. 2018

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Paracoccidioidomycosis is a common deep fungus infection in South America, particularly in Brazil. It is acquired through inhalation and primary involvement of lungs. Subsequently, dissemination may occur and oral mucosa is frequently affected and actually, in most of the cases the diagnosis is established because of the oral lesions. Thus, the role of the dentist is fundamental to correct diagnosis. However, the involvement of intestine is rarely reported. The current case describes a 36-year-old man who presented abdominal pain and intestinal constipation, being suspected and then confirmed as paracoccidioidomycosis after already be diagnosed with this disease by a dentist through oral manifestations.

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