Endometriose retroperitoneal atípica e uso de tamoxifeno

Naufel, Daniel Zambuzzi; Penachim, Thiago José; Freitas, Leandro Luiz Lopes de; Cardia, Patrícia Prando; Prando, Adilson

doi:10.1590/0100-3984.2013.1774

Cited by 6 publications

(14 citation statements)

References 9 publications

(12 reference statements)

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“…Compared to ovarian endometriosis, very little is known about deeply infiltrating endometriosis. In this form, endometriosis can spread beyond organ borders and infiltrate various structures like sacrouterine ligament, the rectovaginal septum, the fornix of the vagina, the rectosigmoid, the urinary bladder or the ureter or also the small intestine [1][2][3][4][5].…”

Section: Definitionsmentioning

confidence: 99%

“…Endometriosis has four stages or types: stage I, minimal, with small lesions and shallow endometrial implants on the ovary; stage 2, mild, with light lesions and shallow implants on the ovary and the pelvic lining; stage 3, moderate, with deep and more implants on the ovary and pelvic lining; and stage 4, severe, with deep implants on the pelvic lining and ovaries [1][2][3][4][5][6][7][8][9][10][11].…”

Section: Diagnosis and Evolutionmentioning

confidence: 99%

“…Ovarian endometriomas, which are a common feature of endometriosis, create a complex situation for infertile patients [5].…”

Section: Diagnosis and Evolutionmentioning

confidence: 99%

“…In the opinion of many authors, endometriosis is one of the top three causes of female infertility and 30% to 40 % of women with endometriosis are infertile [5][6].…”

Section: Diagnosis and Evolutionmentioning

confidence: 99%

“…Endometriosis implants can be regressively changed by means of suppression of ovarian function [11]. The drugs predominately used today are pure gestagens, progestatives, contraceptives, GnRH analogs, and danazol [5][6][7].…”

Section: Medical Versus Surgical Therapymentioning

confidence: 99%

See 4 more Smart Citations

Endometriosis: When and How We Treat

Saceanu¹,

Pătrașcu²,

Pătraşcu³

et al. 2017

Fertility-Oriented Female Reproductive Surgery

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Endometriosis is a chronic, nonmalignant and estrogen-dependent disease in which endometrial glandular epithelium and stroma are outside the uterine cavity (ovaries, peritoneum, or rectovaginal septum). The prevalence is estimated from 2 to 10% in women of childbearing age and it rises up to 50% in women with infertility. Despite maximal efforts, the therapy of first choice in the management of endometriosis is still unclear. The aim of this chapter is to present an update of its management, emphasizing the benefits and disadvantages of surgical methods. We performed a systematic literature search on the PubMed database of English literature (search terms: endometrioma, surgery, ovarian reserve, assisted reproductive technologies) from 2010 to 2014. For endometrioma, operative laparoscopy proved to be the gold standard. Surgical procedures consist of partial excision of the cyst wall and electro-coagulation of the rest. Stripping technique may be a better method for reducing the recurrence of pain symptoms, recurrence, and reoperation rates, but it raises concerns about ovarian reserve. For endometriosis, surgery often includes partial rectum or sacrouterine ligament resection. Hysterectomy is not obligatory and refused by the young patients. The approach should be laparoscopic and if necessary vaginal assisted. Good cooperation between various disciplines (gynecology, surgery, urology) is mandatory.

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Section: Definitionsmentioning

confidence: 99%

Section: Diagnosis and Evolutionmentioning

confidence: 99%

“…Ovarian endometriomas, which are a common feature of endometriosis, create a complex situation for infertile patients [5].…”

Section: Diagnosis and Evolutionmentioning

confidence: 99%

“…In the opinion of many authors, endometriosis is one of the top three causes of female infertility and 30% to 40 % of women with endometriosis are infertile [5][6].…”

Section: Diagnosis and Evolutionmentioning

confidence: 99%

Section: Medical Versus Surgical Therapymentioning

confidence: 99%

See 3 more Smart Citations

Endometriosis: When and How We Treat

Saceanu¹,

Pătrașcu²,

Pătraşcu³

et al. 2017

Fertility-Oriented Female Reproductive Surgery

View full text Add to dashboard Cite

show abstract

Bilateral ovarian endometriomas after laparoscopic hysterectomy following adjuvant tamoxifen therapy for breast cancer: A case report

Nishiyama

Hayashi

Abe

et al. 2022

Case Reports in Women's Health

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Polypoid endometriosis mimicking invasive cancer in an obese, postmenopausal tamoxifen user

Jaegle

Barnett

Stralka

et al. 2017

Gynecologic Oncology Reports

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BackgroundTamoxifen is a medication often used for the treatment and prevention of breast cancer. It is classically associated with several gynecological side effects to include a thickened endometrial stripe, increased uterine polyp formation, and an increased risk of uterine cancer. Rarely tamoxifen use has been associated with proliferation of endometriosis often severe enough to mimic a late-stage gynecologic malignancy.CaseA 62-year-old Gravida 0 postmenopausal female with a medical history of severe obesity, infertility, and preventative tamoxifen use presented for evaluation of gross hematuria. A CT urogram was performed and demonstrated findings concerning for carcinomatosis, likely gynecologic in origin. Cervical cancer screening was up-to-date and she had a negative colonoscopy within the prior 2 years. Serum tumor markers were remarkable only for a mildly elevated CA125 of 37.6. Diagnostic laparoscopy demonstrated apparent operable carcinomatosis limited to the pelvis. The procedure was converted to an exploratory laparotomy, where radical tumor cytoreduction was performed to no gross residual disease. Frozen sections performed intraoperatively were unclear of origin but suggestive of low malignant potential. Final pathology resulted for endometriosis.ConclusionThis case illustrates a presentation of endometriosis in a postmenopausal woman mimicking advanced mullerian malignancy. The patient's estrogenic state from obesity in combination with the agonist action of the tamoxifen likely contributed to her rare presentation. While findings such as a thickened endometrial stripe are typical of tamoxifen use, such widespread proliferation of endometriosis resulting in a pelvic mass, genito-urinary obstruction, and plaque-like pelvic spread are not.PrécisEndometriosis is a benign estrogen dependent condition rarely problematic in a postmenopausal patient. Tamoxifen use in the setting of an obese patient may contribute to a proliferation of pre-existing endometriosis which resembles an aggressive late-stage gynecological malignancy.

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Endometriose retroperitoneal atípica e uso de tamoxifeno

Cited by 6 publications

References 9 publications

Endometriosis: When and How We Treat

Endometriosis: When and How We Treat

Bilateral ovarian endometriomas after laparoscopic hysterectomy following adjuvant tamoxifen therapy for breast cancer: A case report

Polypoid endometriosis mimicking invasive cancer in an obese, postmenopausal tamoxifen user

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