First detection of natural infection of Aedes aegypti with Zika virus in Brazil and throughout South America

Ferreira-de-Brito, Anielly; Ribeiro, Ivonizete Pires; Miranda, Rafaella Moraes de; Fernandes, Rosilainy Surubi; Campos, Stéphanie Silva; Silva, Keli Antunes Barbosa da; Castro, María G.; Bonaldo, Myrna C.; Brasil, Patrícia; Lourenço‐de‐Oliveira, Ricardo

doi:10.1590/0074-02760160332

Cited by 156 publications

(150 citation statements)

References 24 publications

(37 reference statements)

Supporting

Mentioning

146

Contrasting

Order By: Relevance

Section: Zika Virus (Zikv) Emerged In Yap Island Inmentioning

confidence: 99%

“…For example, mosquitoes carry other insect-specific viruses including flaviviruses, which could easily lead to misleading conclusions about the presence of ZIKV using microscopy and even immunofluorescence labelling approaches. Moreover, natural infection in domestic Culex mosquitoes have never been found nor convincingly demonstrated in surveys conducted in ZIKV endemic and epidemic areas [12,13,62,63].Although mosquitoes of the Cx. pipiens complex are known spreaders of infectious agents including arboviruses, the flavivirus St Louis encephalitis virus or the alphavirus Sindbis virus [27,28], we suggest that this is not the case for ZIKV which belongs to the Spondweni serogroup with Spondweni virus, and both flaviviruses are transmitted by Aedes spp.…”

mentioning

confidence: 99%

“…An enzootic cycle limited to Africa and Asia with occasional spillover events has been described [10,11]. In the current outbreak in the Americas, ZIKV is believed to be mainly transmitted by the human-biting mosquito Aedes aegypti [12,13]. Whether a similar enzootic cycle in the Americas can be established is not known and it has been suggested that such a process would make eradication efforts 'practically impossible' [14].…”

mentioning

confidence: 99%

See 2 more Smart Citations

Culex quinquefasciatus mosquitoes do not support replication of Zika virus

Lourenço‐de‐Oliveira

Marques

Sreenu

et al. 2018

Journal of General Virology

Self Cite

View full text Add to dashboard Cite

The rapid spread of Zika virus (ZIKV) in the Americas raised many questions about the role of Culex quinquefasciatus mosquitoes in transmission, in addition to the key role played by the vector Aedes aegypti. Here we analysed the competence of Cx. quinquefasciatus (with or without Wolbachia endosymbionts) for a ZIKV isolate. We also examined the induction of RNA interference pathways after viral challenge and the production of small virus-derived RNAs. We did not observe any infection nor such small virus-derived RNAs, regardless of the presence or absence of Wolbachia. Thus, Cx. quinquefasciatus does not support ZIKV replication and Wolbachia is not involved in producing this phenotype. In short, these mosquitoes are very unlikely to play a role in transmission of ZIKV. Micronesia and then in French Polynesia in 2013-2014, and after affecting most of the South Pacific islands, the virus was eventually detected in the Americas in 2015 [1][2][3][4]. The increased number of infections in humans included cases with unusually severe symptoms such as Guillain-Barr e syndrome and developmental abnormalities in newborns that are now described as congenital Zika syndrome [5][6][7][8]. As there are currently no licensed vaccines or specific therapies, the only way to interrupt ZIKV transmission is by controlling mosquito populations [9]. An enzootic cycle limited to Africa and Asia with occasional spillover events has been described [10,11]. In the current outbreak in the Americas, ZIKV is believed to be mainly transmitted by the human-biting mosquito Aedes aegypti [12,13]. Whether a similar enzootic cycle in the Americas can be established is not known and it has been suggested that such a process would make eradication efforts 'practically impossible' [14]. Experimental infections with the epidemic ZIKV genotypes demonstrated that populations of Ae. aegypti and Ae. albopictus mosquitoes, which are associated with a risk of local transmission [15] as well other aedine species were heterogeneously and weakly competent for transmission [16][17][18][19][20][21][22][23][24][25]. Therefore, the potential role of other anthropophilic mosquitoes in the ZIKV outbreak raised a question which took time to be addressed [26]. Culex quinquefasciatus Say is an opportunistic blood feeder predominant in urban settings throughout the tropics where it is frequently the most annoying biting pest to humans [27]. This night-active mosquito is also the vector of many pathogens including arboviruses such as West Nile and St. Louis encephalitis viruses [28], which belong to the genus Flavivirus of the family Flaviviridae and are related to ZIKV. Both Cx. quinquefasciatus and Culex pipiens (from temperate regions) mosquitoes of the Cx. pipiens complex were not able to experimentally transmit ZIKV and no viral particles were detected in mosquito saliva up to 21 days after exposure to an infectious blood meal [17-20, 25, 29-36], though different results were recorded with other Cx. quinquefasciatus strains [37,38]. Even after injection o...

show abstract

Section: Zika Virus (Zikv) Emerged In Yap Island Inmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Culex quinquefasciatus mosquitoes do not support replication of Zika virus

Lourenço‐de‐Oliveira

Marques

Sreenu

et al. 2018

Journal of General Virology

Self Cite

View full text Add to dashboard Cite

show abstract

“…ika disease is spread to humans by transfer of Zika virus (ZIKV) primarily through the bites of infected Aedes aegypti or Aedes albopictus mosquitoes (1,2) and secondarily by sexual (3) or vertical (4-6) transmission. The majority of ZIKV infections are asymptomatic or mild with low-grade fever, arthralgia, conjunctivitis, and rash (7), while a lower frequency of cases may result in congenital microcephaly via in utero infections in infants and Guillain-Barré syndrome in adults (4)(5)(6)8).…”

mentioning

confidence: 99%

Antibody Responses to Zika Virus Infections in Environments of Flavivirus Endemicity

Keasey

Pugh

Jensen

et al. 2017

Clin Vaccine Immunol

View full text Add to dashboard Cite

Zika virus (ZIKV) infections occur in areas where dengue virus (DENV), West Nile virus (WNV), yellow fever virus (YFV), and other viruses of the genus Flavivirus cocirculate. The envelope (E) proteins of these closely related flaviviruses induce specific long-term immunity, yet subsequent infections are associated with cross-reactive antibody responses that may enhance disease susceptibility and severity. To gain a better understanding of ZIKV infections against a background of similar viral diseases, we examined serological immune responses to ZIKV, WNV, DENV, and YFV infections of humans and nonhuman primates (NHPs). Using printed microarrays, we detected very specific antibody responses to primary infections with probes of recombinant E proteins from 15 species and lineages of flaviviruses pathogenic to humans, while high cross-reactivity between ZIKV and DENV was observed with 11 printed native viruses. Notably, antibodies from human primary ZIKV or secondary DENV infections that occurred in areas where flavivirus is endemic broadly recognized E proteins from many flaviviruses, especially DENV, indicating a strong influence of infection history on immune responses. A predictive algorithm was used to tentatively identify previous encounters with specific flaviviruses based on serum antibody interactions with the multispecies panel of E proteins. These results illustrate the potential impact of exposure to related viruses on the outcome of ZIKV infection and offer considerations for development of vaccines and diagnostics.

show abstract

“…Recently, a field study demonstrated the occurrence of naturally-infected Ae. aegypti in the city of Rio de Janeiro (Brazil), confirming the species potential to transmit ZIKV to humans (Ferreira-de-Brito et al, 2016). The entomological surveillance in endemic regions is an essential activity to monitor the circulation of ZIKV and the potential of new outbreaks to occur.…”

Section: Zika Virus Infectionmentioning

confidence: 91%

Abbreviations and acronyms

2018

Safety Assessment of Transgenic Organisms in the Environment, Volume 8

View full text Add to dashboard Cite

This work is published under the responsibility of the Secretary-General of the OECD. The opinions expressed and arguments employed herein do not necessarily reflect the official views of OECD member countries.This document, as well as any data and any map included herein, are without prejudice to the status of or sovereignty over any territory, to the delimitation of international frontiers and boundaries and to the name of any territory, city or area.Please cite this publication as: OECD (2018) The statistical data for Israel are supplied by and under the responsibility of the relevant Israeli authorities. The use of such data by the OECD is without prejudice to the status of the Golan Heights, East Jerusalem and Israeli settlements in the West Bank under the terms of international law.Photo credits: Cover © Maks Ershov.Corrigenda to OECD publications may be found on line at: www.oecd.org/about/publishing/corrigenda.htm. © OECD 2018You can copy, download or print OECD content for your own use, and you can include excerpts from OECD publications, databases and multimedia products in your own documents, presentations, blogs, websites and teaching materials, provided that suitable acknowledgment of the source and copyright owner(s) is given. All requests for public or commercial use and translation rights should be submitted to rights@oecd.org. Requests for permission to photocopy portions of this material for public or commercial use shall be addressed directly to the Copyright Clearance Center (CCC) at info@copyright.com or the Centre francais d'exploitation du droit de copie (CFC) at contact@cfcopies.com. FOREWORD │ 3SAFETY ASSESSMENTOF TRANSGENIC ORGANISMSIN THE ENVIRONMENT, VOLUME 8 © OECD 2018 ForewordModern biotechnologies are applied to plants species (crops, flowers, trees), animals and micro-organisms. The safety of the resulting transgenic organisms when released in the environment for their use in agriculture, forestry, the food and feed industry or for other applications represents a challenging issue. Genetically engineered products are rigorously assessed by their developers during their elaboration, and by governments when ready for release, to ensure high safety standards. This remains essential with new biotechnology developments using insects to fight against disease outbreaks: engineered mosquitoes need to be evaluated through a scientifically sound approach to risk/safety assessment that will inform biosafety regulators and support the decision concerning the release of these novel organisms in the environment.The OECD offers a long-standing recognised expertise in biosafety and contributes to facilitating an harmonised approach. The OECD's Working Group on Harmonisation of Regulatory Oversight in Biotechnology (WG-HROB) was established in 1995. The WG-HROB gathers national authorities responsible for the environmental risk/safety assessment of products of modern biotechnology in OECD countries and other economies. International organisations and experts involved in biosafety activities are a...

show abstract

First detection of natural infection of Aedes aegypti with Zika virus in Brazil and throughout South America

Cited by 156 publications

References 24 publications

Culex quinquefasciatus mosquitoes do not support replication of Zika virus

Culex quinquefasciatus mosquitoes do not support replication of Zika virus

Antibody Responses to Zika Virus Infections in Environments of Flavivirus Endemicity

Abbreviations and acronyms

Contact Info

Product

Resources

About