Draft genome sequence of a multidrug-resistant Acinetobacter baumannii ST15 (CC15) isolated from Brazil

Abstract

Acinetobacter baumannii is an important pathogen frequently associated with nosocomial outbreaks around the world. In Brazil, A. baumannii has become particularly problematic because of its prevalence and the carbapenems resistance. Here, we report the draft genome sequence of a multidrug-resistant A. baumannii (ST15/CC15) isolated in 2009 from the state of Espírito Santo (Southeast Brazil). We observed important resistance determinant genes in an estimated genome size of 4,102,788 bp with 3,862 predicted coding regions. A detailed report of the genomic data analysis might help to understand the specific features of highly successful strains belonged to a relevant complex clonal in different Brazilian geographical regions.

Whole-Genome-Sequence-Based Characterization of Extensively Drug-Resistant Acinetobacter baumannii Hospital Outbreak

“…This is the first report of ST-502 and ST-2059 A. baumannii in Lebanon. Carbapenem-resistant ST-502 isolates have been reported previously in Brazil (33), Bulgaria (34), and South Africa (35). bla OXA-72 was first identified in 2004 in A. baumannii isolated from Taiwan, and since then it was detected in a few other countries, including Brazil, France, and the United States (36).…”

Comparative Genomics of Acinetobacter baumannii Clinical Strains From Brazil Reveals Polyclonal Dissemination and Selective Exchange of Mobile Genetic Elements Associated With Resistance Genes

“…Although Acinetobacter MDR strains belonging to different clonal complexes have been reported from Brazil (Chagas et al, 2015;Turano et al, 2016;Pagano et al, 2017;Da Silva et al, 2018), no comprehensive genome-wide comparative analysis of Brazilian strains has been conducted and a need for further sequencing from South American strains has recently been pointed out (Hamidian and Nigro, 2019). In the present study, we sequenced the genomes of 46 Acinetobacter clinical strains from five different hospitals located in Recife, a large metropolitan area of Northeastern Brazil, to reveal the genetic features and the outbreak potential of multiple clonal lineages and circulating strains of this pathogen.…”