Efficacy of voriconazole in experimental rat paracoccidioidomycosis

Granzoto, Daniela Silva; Vitali, Lúcia Helena; Martínez, Roberto

doi:10.1590/0037-868216432013

Cited by 29 publications

(22 citation statements)

References 34 publications

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“…The risk factors for death in patients with kala-azar by L. infantum have been identifi ed, and prognostic models based on clinical scores have been developed (5) (6) (25) (28) . In a recent meta-analysis, jaundice, thrombocytopenia, hemorrhage, human immunodefi ciency virus-1 (HIV-1) co-infection, diarrhea, age <5 years or >40-50 years, severe neutropenia, dyspnea, and bacterial infections were important risk factors for VL-related death.…”

Section: Introductionmentioning

confidence: 99%

Predicting death from kala-azar: construction, development, and validation of a score set and accompanying software

Costa

Rocha

Chaves³

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Section: Introductionmentioning

confidence: 99%

Predicting death from kala-azar: construction, development, and validation of a score set and accompanying software

Costa

Rocha

Chaves³

et al. 2016

Rev. Soc. Bras. Med. Trop.

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“…In Brazil, human cases have been described in all five regions of the country, with a mean lethality of 5.8% (Braga et al . ; MS ; de Araújo et al . ).…”

Section: Introductionmentioning

confidence: 99%

Serological diagnosis of canine visceral leishmaniasis in Brazil: systematic review and meta‐analysis

Peixoto

Oliveira²,

Romero³

2014

Tropical Med Int Health

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Abstractobjective To evaluate the quality and accuracy of serological diagnosis of canine visceral leishmaniasis in the Americas.methods A systematic review found original studies in the databases MEDLINE, EMBASE and LILACS up to November 2012 and in complementary sources up to February 2013. Studies were evaluated in accordance with QUADAS 2 and STARD parameters and recommended in accordance with GRADE parameters. Meta-analysis was carried out with Meta-DiSc software, using the randomeffect model.results Two hundred and eighty-four studies were identified, of which 25 met the inclusion criteria, comprising the final synthesis. All but one was conducted in Brazil, and only two were judged to be of good quality. 15 studies involving immuno-enzymatic tests with crude antigens (cELISA), 11 studies on indirect immunofluorescence tests (IFAT) and three on the immunochromatographic dual-path platform (DPP) test were meta-analysed. The combined results for sensitivity and specificity were cELISA conclusion Enzyme-linked immunosorbent assay with crude antigens and DPP tests have moderate accuracy for the diagnosis of canine visceral leishmaniasis, and the quality of the design, implementation and analysis of validation studies on diagnostic tests for this disease urgently require improvement. The recommendation for use of the evaluated tests is based on evidence that is scarce and restricted to Brazil.

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“…Reducing mortality rates requires early diagnosis, which in turn depends on early suspicion followed by prompt intervention. 41 Anaemia, neutropaenia and thrombocytopaenia are frequently seen in VL cases, 30,[32][33][34]42 reflecting the occurrence of bone marrow suppression, aemolysis and splenic sequestration, 43 conditions that predispose to infection and haemorrage, increasing the risk of death. A study conducted in Sã o Paulo found that lethality was associated with haemoglobin levels v5 g/dl, but not with leucocyte or platelet counts.…”

Section: Discussionmentioning

confidence: 99%

“…30 In the present study, lethality was not associated with lower blood cell levels, lower albumin or higher creatinine. More detailed studies are needed, particularly because the populations investigated in the studies cited, 11,30,[32][33][34]42,44 were largely heterogeneous or comprised only children. Infection and haemorrage are classic complications of VL.…”

Section: Discussionmentioning

confidence: 99%

Late diagnosis: a factor associated with death from visceral leishmaniasis in elderly patients

Driemeier

Oliveira

Druzian

et al. 2015

Pathogens and Global Health

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Introduction: Visceral leishmaniasis (VL) is among the seven global endemic diseases assigned a high priority by the World Health Organization. In Latin America, most cases occur in Brazil. Despite the availability of intensive treatment resources and protocols for specific treatment, lethality rates for VL have increased in several regions in the country over the past 10 years, particularly in patients under one and over 50 years of age. As the growth of the elderly population accelerates in Brazil, VL poses a greater challenge to public health. Given the scarcity of studies addressing the disease in this age group, the purpose of this study was to identify factors associated with VL lethality among the elderly. Methods/Key findings: This analytical, cross-sectional epidemiological study comprised 80 elderly patients who sought treatment at the teaching hospital of the Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil, in the period 2000-2013.Clinical, laboratory and treatment variables were investigated from records of elderly patients with VL diagnosis confirmed by at least one laboratory test positive (culture for parasite or direct parasitological examination; reactive immunofluorescence; immunochromatographic test with recombinant antigens) or patients without laboratory confirmation who lived in endemic areas and responded favorably to therapeutic trial, as defined by the Brazilian Ministry of Health. Of the 80 patients included, 78 tested positive to at least one exam; in two cases, diagnosis was based on clinical and epidemiological criteria. The lethality rate was 20%. Multivariate analysis revealed an association between death and time elapsed from symptom onset.

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Efficacy of voriconazole in experimental rat paracoccidioidomycosis

Abstract: The results suggest that patients aged between 12 and 18 months, with platelet counts below 85,000/mm3, and respiratory abnormalities at admission should be considered potentially severe.

Cited by 29 publications

References 34 publications

Predicting death from kala-azar: construction, development, and validation of a score set and accompanying software

Predicting death from kala-azar: construction, development, and validation of a score set and accompanying software

Serological diagnosis of canine visceral leishmaniasis in Brazil: systematic review and meta‐analysis

Late diagnosis: a factor associated with death from visceral leishmaniasis in elderly patients

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