Brazilian Protocol for Sexually Transmitted Infections 2020: acquired syphilis

Freitas, Francisca Lidiane Sampaio; Benzaken, Adèle Schwartz; Passos, Mauro Romero Leal; Coêlho, Ivo Castelo Branco; Miranda, Angélica Espinosa

doi:10.1590/0037-8682-616-2020

Cited by 9 publications

(13 citation statements)

References 33 publications

(40 reference statements)

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“…Since 2012, the Brazilian Health Ministry has decentralized rapid testing to primary healthcare [32]. Brazil has one of the world's largest universal health systems, but access to STI testing can be difficult due to the low coverage of primary care [33].…”

Section: Discussionmentioning

confidence: 99%

“…Brazil has one of the world's largest universal health systems, but access to STI testing can be difficult due to the low coverage of primary care [33]. Therefore, a reverse testing algorithm for syphilis diagnosis is recommended [32], which facilitates testing for HIV and syphilis in populations outside basic health units, especially in the context of a pandemic.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, in addition to the growing trend in the increase in the number of cases of elderly people with HIV, syphilis, and other STIs, there is also the aging of the HIV epidemic [2,8,18,[23][24][25][26][27][28][29][30][31][32][33][34]. In the United States, fifty percent of people living with HIV in the are now older than 50 years of age.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence and Vulnerability Factors Associated with HIV and Syphilis in Older People from Subnormal Agglomerate, Brazilian Amazon

et al. 2022

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Background: This study aimed to estimate the prevalence of HIV and syphilis and associated factors among elderly people from subnormal agglomerations in a city in the Brazilian Amazon. Methods: An observational, cross-sectional study was carried out in a subnormal agglomerate from the Brazilian Amazon. Data collection was conducted from August 2021 to February 2022, using a structured questionnaire. Whole blood samples were collected to perform a rapid test for HIV and syphilis. People aged 50 and over were included in the study, and the sample consisted of 213 participants. The odds ratio was calculated by multiple logistic regression. Results: A total of 203 participants with a mean age of 63.5 years were considered (95% CI: 62.4; 64.6; standard deviation: 8.1; minimum age: 50 years and maximum age: 94 years). The prevalence of either HIV or syphilis was 16.4% (35/213; 95% CI: 0.11; 0.21); syphilis was 15.5% (33/213) and HIV was 1.40% (3/213). One coinfection (0.46%; 1/213) was registered. In the final multiple logistic regression, the elderly with an education level of illiterate/elementary were two times more likely to have a positive rapid test result for HIV or syphilis. Conclusions: Testing for HIV and syphilis identified that STI represented a burden on populations affected by socioeconomic inequality.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Prevalence and Vulnerability Factors Associated with HIV and Syphilis in Older People from Subnormal Agglomerate, Brazilian Amazon

et al. 2022

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“…The immunohistochemistry showed the presence of anti-treponemal antibodies and numerous spirochetes ( Figure 3 ). The clinical protocol and therapeutic guidelines for sexually transmitted infections 5 recommend the use of benzathine benzylpenicillin 2.4 million international units (IU), intramuscularly (IM), in a single-dose (1.2 million in each gluteus). However, most treated cases report a better outcome with the administration of three doses 6 , 7 .…”

Section: Case Reportmentioning

confidence: 99%

Atypical presentation of secondary syphilis: annular lesions in an elderly patient

Pagani

Pacheco

Venier

et al. 2021

Rev. Inst. Med. trop. S. Paulo

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Syphilis is a chronic bacterial sexually transmitted infectious disease caused by Treponema pallidum . Different age groups are affected by heterogeneous clinical forms of the disease. We report a case of atypical secondary syphilis in an elderly patient with diffuse annular erythematous lesions on the chest, back, upper and lower limbs diagnosed by histopathological, immunohistochemical and serological tests.

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“…This etiological agent can infect practically any organ or tissue in the body, causing multiple and diverse clinical manifestations 2 . The transmission occurs mainly during sexual contact; therefore, it is considered a sexually transmitted infection (STI) 3 . Transmission occurs at a higher rate owing to the fact that most infected people are unaware of their serological state because individuals may have few or no symptoms and can still transmit the disease to sexual partners 4 .…”

Section: Introductionmentioning

confidence: 99%

Burden of syphilis in Brazil and federated units, 1990-2016: estimates from the Global Burden of Disease Study 2019

Bezerra

Castro

Machado

et al. 2022

Rev. Soc. Bras. Med. Trop.

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Background: Syphilis is a chronic infectious disease that has created challenging situations for humanity for centuries. Transmission can occur sexually or vertically, with great repercussions on populations, particularly among women and children. The present study presents information on the main burden imposed by syphilis generated by the Global Burden of Disease (GBD) Study 2019 for Brazil and its 27 federated units. Methods:We described the metrics of incidence, deaths, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life years (DALYs), standardized by age and per 100,000 inhabitants, from 1990 to 2019, and we compared the disease burden between the years 1990 and 2019. Results:In Brazil, the disease burden increased between 2005 and 2019 for all metrics. Although a higher incidence of syphilis was found among women in 2019, DALYs [YLLs (males: 15.9%; females: 21.8%), YLDs (males: 25.0%; females: 50.0%), and DALYs (males: 16.2%; females: 22.4%)] were higher among men. In 2019, the highest DALY rate per 100,000 inhabitants was observed in individuals aged above 50 years. The State of Maranhão presented the highest values of DALYs {1990: 165.2 [95% uncertainty interval (UI) 96.2-264.4]; 2005: 43.8 [95% UI 30.3-62.4]; 2019: 29.1 [95% UI 19.8-41.1]} per 100,000 inhabitants in the three years analyzed. Conclusions:The burden of syphilis has increased in recent years. Men presented higher DALYs, although the incidence of the disease was higher in women. Syphilis affects a large number of people across all age groups, causing different degrees of disability and premature death (DALYs).

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Brazilian Protocol for Sexually Transmitted Infections 2020: acquired syphilis

Cited by 9 publications

References 33 publications

Prevalence and Vulnerability Factors Associated with HIV and Syphilis in Older People from Subnormal Agglomerate, Brazilian Amazon

Prevalence and Vulnerability Factors Associated with HIV and Syphilis in Older People from Subnormal Agglomerate, Brazilian Amazon

Atypical presentation of secondary syphilis: annular lesions in an elderly patient

Burden of syphilis in Brazil and federated units, 1990-2016: estimates from the Global Burden of Disease Study 2019

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