Differences in virulence markers between Helicobacter pylori strains from the Brazilian Amazon region

Silva, Mario Ribeiro da; Vinagre, Ruth Maria Dias Ferreira; Silva, Adenielson Vilar e; Oliveira, Cláudia; Santos, Kemper Nunes; Costa, Renata Aparecida Andrade da; Fecury, Amanda Alves; Corvelo, Tereza Cristina de Oliveira; Quaresma, Juarez Antônio Simões; Martins, Luisa Carí­cio

doi:10.1590/0037-8682-1290-2013

Cited by 4 publications

(1 citation statement)

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“…This prevalence is lower than that reported in Central and South America [15, 19, 60], but it is in agreement with previous studies in Mexico [10, 27]. The cagA -positive strains of H. pylori have been associated with a more severe inflammation of the gastric mucosa that precedes atrophic gastritis, peptic ulcer and gastric cancer [61–65].…”

Section: Discussionsupporting

confidence: 89%

Helicobacter pylori vacA s1m1 genotype but not cagA or babA2 increase the risk of ulcer and gastric cancer in patients from Southern Mexico

et al. 2017

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BackgroundThe vacA, cagA and babA2 genotypes of Helicobacter pylori are associated with gastric pathology. The objectives were to determine the frequency of infection and distribution of the vacA, cagA and babA2 genotypes of H. pylori in patients with gastric ulcer, chronic gastritis and gastric cancer, and to evaluate the association of virulent genotypes with diagnosis.MethodsWe studied 921 patients with symptoms of dyspepsia or with presumptive diagnosis of gastric cancer. The DNA of H. pylori and the vacA, cagA and babA2 genes was detected by PCR in total DNA from gastric biopsies. The association of H. pylori and of its cagA, vacA and babA2 genotypes with diagnosis was determined by calculating the odds ratio (OR).ResultsChronic gastritis was confirmed in 767 patients, gastric ulcer in 115 and cancer in 39. The prevalence of H. pylori was 47.8, 49.6 and 61.5% in those groups, respectively. H. pylori was more frequent in the surrounding tissue (69.2%) than in the tumor (53.8%). The vacA s1m1 genotype predominated in the three groups (45.2, 61.4 and 83.3%, respectively). H. pylori was associated with cancer (ORadjusted = 2.08; 95% CI 1.05–4.13; p = 0.035) but not with ulcer (ORadjusted = 1.07; 95% CI 0.71–1.61; p = 0.728). The s1m1 genotype was associated with ulcer and cancer (ORadjusted = 2.02; 95% CI 1.12–3.62; p = 0.019 and ORadjusted = 6.58; 95% CI 2.15–20.08; p = 0.001, respectively). babA2 was associated with gastric cancer, and cagA was not associated with the diagnosis.ConclusionsIn population from Southern Mexico, H. pylori and the s1m1 genotype were associated with gastric cancer and the s1m1/cagA+/babA2+ strains predominated in tumor and adjacent tissue.

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