Haemoglobin and red cell counts in leptospirosis patients infected with different serovars

Craig, Scott B.; Smythe, Lee D.; Graham, G. C.; Burns, Mary‐Anne; McMahon, Jamie; Dohnt, Michael F.; Tulsiani, Suhella M.; McKay, David

doi:10.1590/0037-8682-1013-2013

Cited by 12 publications

(11 citation statements)

References 13 publications

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“…Moderate increase of PMN counts have been reported in patients with Leptospira and particularly in the most severe forms [4–6]. Neutrophilia has also been found in other Gram-negative bacterial infection and to control the infectious challenge and to limit tissue damage [29,30].…”

Section: Discussionmentioning

confidence: 99%

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Major Neutrophilia Observed in Acute Phase of Human Leptospirosis Is Not Associated with Increased Expression of Granulocyte Cell Activation Markers

et al. 2016

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It has long been known that pathogenic Leptospira can mobilize the immune system but the specific contribution of neutrophils to control the infectious challenge remains to be clarified. We herein analyzed the phenotype of circulating neutrophils of patients with leptospirosis and healthy controls for the expression of toll-like receptor (TLR) type 2 (TLR2, to sense the leptospiral LPS) and several activation markers: interleukin 8 chemokine receptor CD182 (CXCR2), CD11b of the integrin/opsonin complement receptor type 3 (CR3) and CD15 (ligand of the selectin). The plasmatic level of the main CD182 ligand, interleukin 8 (CXCL8), was measured by ELISA. Hospitalized leptospirosis cases showed marked neutrophilia, particularly in the most severe cases. Interestingly, TLR2 was significantly increased in leptospirosis but identical levels of CD182 and CD11b were detected when compared to controls. CD15 was significantly decreased on neutrophils in leptospirosis but returned to normal within 1 month. Basal levels of IL-8 were measured in control subjects and were not increased in leptospirosis cases at the initial stage of the disease. In conclusion, we observed that neutrophils failed to regulate the expression of several of the receptors involved in cell activation and recruitment. This study further emphasizes the paradigm that neutrophils may be impaired in their overall capacity to thwart bacterial infection in leptospirosis patients.

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Section: Discussionmentioning

confidence: 99%

“…During the first two weeks of leptospirosis, PMN count is usually characterized by a moderate increase and is correlated to disease severity [4–6]. This is also a non-specific feature of acute sepsis and bacteremia in general.…”

Section: Introductionmentioning

confidence: 99%

Major Neutrophilia Observed in Acute Phase of Human Leptospirosis Is Not Associated with Increased Expression of Granulocyte Cell Activation Markers

et al. 2016

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“…Since MAT cannot definitively identify an infecting serovar, the serovar detected by the MAT is often described as ' presumptive '. It should be noted that the MAT panel used in Australia has high specificity for identifying infecting serovars circulating in Australia [24]. In recent years, serovars Arborea, Zanoni and Australis have been dominant in human leptospirosis infections in Queensland [25].…”

Section: Discussionmentioning

confidence: 99%

Leptospirosis following a major flood in Central Queensland, Australia

et al. 2012

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Throughout December 2010 and January 2011, Queensland experienced widespread flooding due to unusually protracted and heavy rainfalls. In mid-January 2011, four individuals from a small community in Central Queensland were hospitalized with leptospirosis. A further five cases were subsequently identified from around Central Queensland, bringing the total to nine. Microscopic agglutination testing found that serovar Arborea (Leptospira borgpetersenii serovar Arborea) was presumptively responsible for leptospirosis in seven of nine confirmed cases. Serovars Hardjo and Australis were identified in samples from two remaining cases. All cases had exposure to flood water. No single exposure source was identified. This is the first reported outbreak of leptospirosis in Central Queensland and the first report of leptospirosis cases associated with flood water inundation in Queensland. Public health authorities should continue to promote awareness of leptospirosis in flood-affected populations. Healthcare providers must maintain a high level of suspicion for leptospirosis during and after flood events.

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“…Serum was separated and analyzed for creatinine, urea (BUN), and transaminases (AST, ALT), white blood cells (WBC) and red blood cells (RBC) count. WBC and RBC count were determined by hematocytometer method using Türck's solution and saline solution [13,14] . BUN was measured by Berthelot colorimetric method [15] .…”

Section: Acute Toxicity Testmentioning

confidence: 99%

Assessment of antidiabetic activity and acute toxicity of leaf extracts from Physalis peruviana L. in guinea-pig

Kasali

Kadima

Mpiana

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

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Haemoglobin and red cell counts in leptospirosis patients infected with different serovars

Cited by 12 publications

References 13 publications

Major Neutrophilia Observed in Acute Phase of Human Leptospirosis Is Not Associated with Increased Expression of Granulocyte Cell Activation Markers

Major Neutrophilia Observed in Acute Phase of Human Leptospirosis Is Not Associated with Increased Expression of Granulocyte Cell Activation Markers

Leptospirosis following a major flood in Central Queensland, Australia

Assessment of antidiabetic activity and acute toxicity of leaf extracts from Physalis peruviana L. in guinea-pig

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