Assessment of antidiabetic activity and acute toxicity of leaf extracts from Physalis peruviana L. in guinea-pig

Kasali, Félicien Mushagalusa; Kadima, Justin Ntokamunda; Mpiana, Pius T.; Ngbolua, Koto-te-Nyiwa; Tshibangu, Damien S. T.

doi:10.1016/s2221-1691(13)60166-5

Cited by 46 publications

(39 citation statements)

References 19 publications

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“…Des nombreux travaux ont été réalisés sur l'activité pharmacologique des plantes antidiabétique utilisées dans la médecine traditionnelle à travers la RDC, l'Afrique et le monde. A titre illustratif, on peut citer les plantes suivantes : Allium cepa (Kook et al, 2009), Stachytarpheta indica (Silambujanaki et al, 2009), Urtica dioica (Das et al, 2011), Persea americana (Lima et al, 2012), Physalis peruvianna (Kasali et al, 2013b). Cependant, de Nos jours, force est de constater que la méconnaissance des composés chimiques responsables d'activités biologiques des plantes utilisées cause d'énormes préjudices aux prescripteurs, à la base d'irrationalisme des doses (conduisant au surdosage, au sous dosage, aux intoxications et voir même à la mort).…”

Section: Résuméunclassified

Contribution à l’étude photochimique de quelques plantes médicinales antidiabétiques de la ville de Bukavu et ses environs (Sud-Kivu, R.D.Congo).

Mangambu¹,

Mushagalusa²,

Kadima³

2014

J. App. Bioscience.

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Section: Résuméunclassified

Contribution à l’étude photochimique de quelques plantes médicinales antidiabétiques de la ville de Bukavu et ses environs (Sud-Kivu, R.D.Congo).

Mangambu¹,

Mushagalusa²,

Kadima³

2014

J. App. Bioscience.

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“…The brownish yellow to pinkish red wood is moderately hard, and it has an irregular grain and fine texture; it is used for carpentry and making canoes [21].…”

Section: Introductionmentioning

confidence: 99%

Preliminary Phytochemical Content and Antidiabetic Potential Investigations of <i>Panda oleosa</i> (Pierre) Used in Kisangani Areas

Muhoya

Kadima

Ranarivelo

et al. 2017

AJAC

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Panda oleosa Pierre (POP), a tropical plant tree, has been used in traditional medicine in Kisangani city and around to treat various diseases including diabetes and HIV/AIDs. This study aims to evaluate the chemical composition of POP extracts while setting up chromatographic fingerprints for their quality control, and the anti-hyperglycemic potential of trunk bark aqueous extracts of POP. Common chemical reactions were used for identification of main secondary metabolic groups. Thin layer chromatography was used to set up several chromatographic fingerprints of water and alcoholic extracts while evaluating chemical composition. Oral glucose tolerance test served to induce hyperglycemia in a rabbit model. The extracts were given as 25 mg/kg, 50 mg/kg, and 100 mg/kg body weight, 30 minutes before loading animals with glucose 4 g/kg. Blood samples were collected at various times: just before extracts (T-30), before (T0) and after glucose load (T30, T60, T120, and T180). Blood glucose levels were measured with One Touch Glucometer. The identification tests revealed the presence of saponins (3.58%), tannins (5%); alkaloids, quinones, flavonoids, and terpenes sterols could not be formerly detected by the reagents used. Interesting chromatographic spots were observed whose behaviors are of catechic tannin proanthocyanes. The extract significantly reduced glucose levels in dose dependent manner as compared to control and glibenclamide reference groups. The average of mean percentage of reduction in glucose level at T120 with the extract 100 mg/kg was close to that of . These findings back the traditional use of the plant to treat diabetic patients and constitute a foundation for an extensive study to find a new antidiabetic phythomedicine.

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“…Physalis peruviana (Solanaceae) is a medicinal plant widely used in folk medicine for treating diseases such as malaria, asthma, hepatitis, dermatitis, cancer, diuretic, rheumatism, antispasmodic, diuretic, antiseptic, sedative, analgesic diseases, and has antioxidant, antifungal, antibacterial, anti-inflammatory, cataract-cleaning, antidiabetic and anti-parasitic properties (Mariotte et al, 2005;Kasali et al, 2013a;Çakir et al, 2014;Joshi and Joshi, 2015;Lashin et al, 2016;Higaki et al, 2016;Chang et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical and zootechnical studies of Physalis peruviana L. leaves exposured to streptozotocin-induced diabetic rats

Fokunang¹,

Mushagalusa²,

Tembe-Fokunang³

et al. 2017

J. Pharmacognosy Phytother.

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This is a phytochemical and zootechnical study on Physalis peruviana leaves in streptozotocin induced diabetic rats. This was part of a scientific development program of plant resources used in Congolese traditional medicine for the treatment of diabetes mellitus in which individual and community consequences are well established. Different fractions with hexane, ethyl acetate and the residue were obtained from the hydroalcoholic extract of P. peruviana leaves. Phytochemical screening was focused on the usual reactions of characterization based on precipitation and coloration with general reagents. The diabetic conditions were induced in rats by a single administration of streptozotocin (50 mg/kg body weight) intravenously. The positive control group received glibenclamide (6.5 mg/kg body weight) and each test group received 100 mg/kg of body weight. Those groups were compared with a control group which received only a Tween 20 solution (1 ml per 100 g body weight). Zootechnical profiles were evaluated by weight monitoring as well as food and water consumption in rats. Phytochemical screening showed the presence of polyphenols, flavonoids, alkaloids, saponins, tannins, anthocyanins, mucilages, cardiac glycosides, coumarins and betalains in the hydroalcoholic extract and its fractions. A highly significant difference (P ˂ 0.001) of water consumption in opposition to the food intake and weight changes was observed. This study suggested the isolation and characterization of compounds from hydroalcoholic extract from the leaves of P. peruviana L. and its fractions for an extensive antidiabetic investigation.

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Assessment of antidiabetic activity and acute toxicity of leaf extracts from Physalis peruviana L. in guinea-pig

Abstract: International Foundation for Science (IFS)" and "the Organization for the Prohibition of Chemical Weapons (OPCW)" for the fellowship No. F/4921-2.

Cited by 46 publications

References 19 publications

Contribution à l’étude photochimique de quelques plantes médicinales antidiabétiques de la ville de Bukavu et ses environs (Sud-Kivu, R.D.Congo).

Contribution à l’étude photochimique de quelques plantes médicinales antidiabétiques de la ville de Bukavu et ses environs (Sud-Kivu, R.D.Congo).

Preliminary Phytochemical Content and Antidiabetic Potential Investigations of <i>Panda oleosa</i> (Pierre) Used in Kisangani Areas

Phytochemical and zootechnical studies of Physalis peruviana L. leaves exposured to streptozotocin-induced diabetic rats

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Assessment of antidiabetic activity and acute toxicity of leaf extracts from Physalis peruviana L. in guinea-pig

Abstract: International Foundation for Science (IFS)" and "the Organization for the Prohibition of Chemical Weapons (OPCW)" for the fellowship No. F/4921-2.

Cited by 46 publications

References 19 publications

Contribution à l’étude photochimique de quelques plantes médicinales antidiabétiques de la ville de Bukavu et ses environs (Sud-Kivu, R.D.Congo).

Contribution à l’étude photochimique de quelques plantes médicinales antidiabétiques de la ville de Bukavu et ses environs (Sud-Kivu, R.D.Congo).

Preliminary Phytochemical Content and Antidiabetic Potential Investigations of &lt;i&gt;Panda oleosa&lt;/i&gt; (Pierre) Used in Kisangani Areas

Phytochemical and zootechnical studies of Physalis peruviana L. leaves exposured to streptozotocin-induced diabetic rats

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Preliminary Phytochemical Content and Antidiabetic Potential Investigations of <i>Panda oleosa</i> (Pierre) Used in Kisangani Areas