Biofilm inhibition activity of traditional medicinal plants from Northwestern Argentina against native pathogen and environmental microorganisms

Romero, Cintia Mariana; Vivacqua, Cristian Germán; Abdulhamid, María Belén; Baigorí, Mario Domingo; Slanis, Alberto C.; Allori, María Cristina Gaudioso de; Tereschuk, María L.

doi:10.1590/0037-8682-0452-2016

Cited by 26 publications

(17 citation statements)

References 39 publications

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“…Eradication of biofilms is difficult to achieve because of host defences and inherent resistance to antibiotics (Romero et al . ). Biofilm eradication activity of oregano, lemongrass and grapefruit EOs was demonstrated against Staphylococcus biofilms (Nostro et al .…”

Section: Discussionmentioning

confidence: 97%

“…It was reported that eucalyptus oil and thyme oil had strong biofilm inhibitory activity against biofilm-producing isolates including Klebsiella, while clove oil showed weak inhibition (Mathur et al 2013;Al-Shuneigat et al 2014a). Eradication of biofilms is difficult to achieve because of host defences and inherent resistance to antibiotics (Romero et al 2016). Biofilm eradication activity of oregano, lemongrass and grapefruit EOs was demonstrated against Staphylococcus biofilms (Nostro et al 2007;Adukwu et al 2012 Figure 4 Scanning electron micrographs of the established biofilm of Klebsiella pneumoniae after 24 h without treatment (a, b); exposed to thyme oil at a concentration of 10 ll ml À1 (c, d); to thymol at a concentration of 5 lg ml À1 (e, f) or to bromelain at a concentration of 100 mg ml À1 (g, h).…”

Section: Discussionmentioning

confidence: 99%

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Combination of essential oil and ciprofloxacin to inhibit/eradicate biofilms in multidrug-resistant Klebsiella pneumoniae

Mohamed

Khalil

et al. 2018

J Appl Microbiol

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Combination of essential oil and ciprofloxacin to inhibit/eradicate biofilms in multidrug-resistant Klebsiella pneumoniae

Mohamed

Khalil

et al. 2018

J Appl Microbiol

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“…show no antimicrobial activity against human microflora, regarded as central to human immunity, such as Lactobacillus species. An absence of antimicrobial activity against nonpathogenic human bacteria could be beneficial for intestinal disease treatments, in which the intestinal flora must be preserved [ 177 ].…”

Section: Tagetes Spp As Functional Food Additimentioning

confidence: 99%

Tagetes spp. Essential Oils and Other Extracts: Chemical Characterization and Biological Activity

Salehi

Valussi²,

Morais-Braga

et al. 2018

Molecules

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Tagetes (marigold) is native to America, and its cultivation currently extends to other countries in Africa, Asia, and Europe. Many species of this genus, such as T. minuta, T. erecta, T. patula, and T. tenuifolia, are cultivated as ornamental plants and studied for their medicinal properties on the basis of their use in folk medicine. Different parts of the Tagetes species are used as remedies to treat various health problems, including dental, stomach, intestinal, emotional, and nervous disorders, as well as muscular pain, across the world. Furthermore, these plants are studied in the field of agriculture for their fungicidal, bactericidal, and insecticidal activities. The phytochemical composition of the extracts of different Tagetes species parts are reported in this work. These compounds exhibit antioxidant, antiinflammatory, and enzyme inhibitory properties. Cultivation and the factors affecting the chemical composition of Tagetes species are also covered. In the current work, available literature on Tagetes species in traditional medicine, their application as a food preservative, and their antimicrobial activities are reviewed.

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“…Antimicrobial resistance (AMR) has become a major public health concern worldwide as it reduces the effectiveness of antibiotic therapies and increases morbidity, mortality, and health care costs [ 1 ]. Current evidence suggests that free-floating bacteria attach onto solid surfaces and create a complex polysaccharide matrix called the biofilm, which protects them from antimicrobial agents [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Some extracts of neotropical rainforest plants have shown remarkable biofilm inhibitory effects [ 1 , 6 ]. Triterpenes with inhibitory effects against P. aeruginosa biofilms were isolated from Diospyros dendo [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Indigenous Medicinal Plants as Biofilm Inhibitors for the Mitigation of Antimicrobial Resistance

Ampofo

Amponsah

Asante-Kwatia

et al. 2020

Advances in Pharmacological and Pharmaceutical Sciences

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The majority of indigenes in the rural areas of Ghana use herbal medicines for their primary health care. In this study, an ethnobotanical survey was undertaken to document medicinal plants used by traditional healers in the Ejisu-Juaben district in the Ashanti region of Ghana to treat infections and to further investigate the antibiofilm formation properties of selected plants in resisting pathogenic bacteria. Seventy medicinal plants used by traditional practitioners for the treatment of skin infections and wounds were documented from the ethnobotanical survey. Forty out of the seventy plants were collected and their methanol extracts evaluated for antimicrobial activity by the agar diffusion assay. Extracts that showed antibacterial activity were tested for biofilm inhibitory activity, and the most active plant was subsequently purified to obtain the active constituents. Biofilm formation was significantly mitigated by petroleum ether, ethyl acetate, and methanol extracts of Holarrhena floribunda stem bark. Bioassay-guided fractionation of an alkaloidal extract prepared from the methanol fraction led to the isolation of three steroidal alkaloids, namely, holonamine, holadienine, and conessine. The isolated compounds demonstrated varying degrees of biofilm formation inhibitory properties. The current study reveals that screening of indigenous medicinal plants could unravel potential leads to salvage the declining efficacy of conventional antibiotics. Holarrhena floribunda stem bark extract has strong biofilm formation inhibition properties, which could be attributed to the presence of steroidal alkaloids.

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Biofilm inhibition activity of traditional medicinal plants from Northwestern Argentina against native pathogen and environmental microorganisms

Abstract: These five species may represent a source of alternative drugs derived from plant extracts, based on ethnobotanical knowledge from northwest Argentina.

Cited by 26 publications

References 39 publications

Combination of essential oil and ciprofloxacin to inhibit/eradicate biofilms in multidrug-resistant Klebsiella pneumoniae

Combination of essential oil and ciprofloxacin to inhibit/eradicate biofilms in multidrug-resistant Klebsiella pneumoniae

Tagetes spp. Essential Oils and Other Extracts: Chemical Characterization and Biological Activity

Indigenous Medicinal Plants as Biofilm Inhibitors for the Mitigation of Antimicrobial Resistance

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