Encephalitis associated with Zika virus infection and reactivation of the varicella-zoster virus in a Brazilian child

Vieira, Marcelo Adriano da Cunha e Silva; Castro, Alzira Almeida de Sousa; Henriques, Daniele Freitas; Silva, Eliana Vieira Pinto da; Tavares, Fernando Neto; Martins, Lívia Carício; Guimarães, Lucas Melo; Monteiro, Talita Antônia Furtado; Azevedo, Raimunda do Socorro da Silva; Cruz, Ana Cecíclia Ribeiro; Vasconcelos, Pedro Fernando da Costa

doi:10.1590/0037-8682-0447-2017

Cited by 7 publications

(9 citation statements)

References 12 publications

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“…In Brazil, only a single case of encephalitis has been described in an 8-year-old child with ZIKV infection and reactivation of varicella zoster virus. All CSF parameters were normal and this sample was positive for ZIKV by PCR [26].…”

Section: Flaviviruses As Aetiological Agents Of Cns Infectionsmentioning

confidence: 88%

“…[14]. The neurological manifestations described in children were seizures or tonic-clonic seizures, convulsions [5], [14], [26]; meningitis signs with acute onset of fever, headache, vomiting, nuchal rigidity [19]; encephalitis signs of cerebral involvement with altered consciousness or cognition [14], [23], increase of intracranial pressure [18], [19], drowsiness, tremors [19].…”

Section: Clinical Manifestationsmentioning

confidence: 99%

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Flaviviruses as agents of childhood central nervous system infections in Brazil

Marinho

Kroon

2019

New Microbes and New Infections

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Flaviviruses are agents of a major emerging human public health issue and members of this genus have been associated with central nervous system (CNS) infections. In Brazil, a country endemic for some arboviruses, the most clinically relevant neurotropic flaviviruses include Dengue virus and Zika virus. Flaviviruses cause diseases ranging from mild or sub-clinical infections to severe cases as CNS infections. There is a lack of data about the incidence of flaviviruses in the CNS of children in Brazil. In this review, we provide a general overview of several flaviviruses that cause CNS infections in Brazilian children and explore the importance of epidemiological surveillance of CNS infections in cases of flavivirus infections.

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Section: Flaviviruses As Aetiological Agents Of Cns Infectionsmentioning

confidence: 88%

Section: Clinical Manifestationsmentioning

confidence: 99%

Flaviviruses as agents of childhood central nervous system infections in Brazil

Marinho

Kroon

2019

New Microbes and New Infections

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“…Apart from systemic inflammation, ZIKV cause inflammation of brain ( Vieira et al, 2018 ) human retinal pigment epithelium ( Simonin et al, 2019 ), ovary ( Caine et al, 2019 ). Inflammation and seizure-like activities may not be specific to ZIKV, as it is also reported in immunocompromised mice infected with DENV too ( Getts et al, 2007 ; Tsai et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Castanospermine reduces Zika virus infection-associated seizure by inhibiting both the viral load and inflammation in mouse models

et al. 2020

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Zika virus (ZIKV) outbreaks have been reported worldwide, including a recent occurrence in Brazil where it spread rapidly, and an association with increased cases of microcephaly was observed in addition to neurological issues such as GBS that were reported during previous outbreaks. Following infection of neuronal tissues, ZIKV can cause inflammation, which may lead to neuronal abnormalities, including seizures and paralysis. Therefore, a drug containing both anti-viral and immunosuppressive properties would be of great importance in combating ZIKV related neurological abnormalities. Castanospermine (CST) is potentially a right candidate drug as it reduced viral load and brain inflammation with the resulting appearance of delayed neuronal disorders, including seizures and paralysis in an Ifnar1 -/- mouse.

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“…In Brazil, a single case of encephalitis was described in an 8-year-old child with ZIKV infection and reactivation of varicella zoster virus. All CSF parameters were normal; the sample was positive for ZIKV by PCR [26].…”

Section: Flaviviruses As Aetiologic Agents Of Cns Infectionsmentioning

confidence: 95%

“…Neurologic manifestations associated with DENV and ZIKV have been reviewed [14]. The neurologic manifestations described in children were seizures or tonic-clonic seizures, convulsions [5], [14], [26], meningitis signs with acute onset of fever, headache, vomiting and nuchal rigidity [19], encephalitis signs of cerebral involvement with altered consciousness or cognition [23], [14], increased intracranial pressure [18], [19], drowsiness and tremors [19].…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Flaviviruses as agents of childhood central nervous system infections in Brazil

Marinho

Kroon

2019

New Microbes and New Infections

View full text Add to dashboard Cite

Flaviviruses are agents of a major emerging human public health issue, and members of the Flavivirus genus have been associated with central nervous system (CNS) infections. In Brazil, a country endemic for some arboviruses, the most clinically relevant neurotropic flaviviruses include dengue virus and Zika virus. Flaviviruses cause diseases ranging from mild or subclinical infections to severe cases as CNS infections. There is a lack of data about the incidence of flaviviruses in the CNS of children in Brazil. In this review, we provide a general overview of several flaviviruses that cause CNS infections in Brazilian children and explore the importance of epidemiologic surveillance of CNS infections in cases of Flavivirus infections.

show abstract

Encephalitis associated with Zika virus infection and reactivation of the varicella-zoster virus in a Brazilian child

Cited by 7 publications

References 12 publications

Flaviviruses as agents of childhood central nervous system infections in Brazil

Flaviviruses as agents of childhood central nervous system infections in Brazil

Castanospermine reduces Zika virus infection-associated seizure by inhibiting both the viral load and inflammation in mouse models

Flaviviruses as agents of childhood central nervous system infections in Brazil

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