Detection of antibodies to Oropouche virus in non-human primates in Goiânia City, Goiás

Gibrail, Marize Moreira; Fiaccadori, Fabíola Souza; Souza, Menira; Almeida, Tâmera Nunes Vieira; Chiang, Jannifer Oliveira; Martins, Lívia Carício; Ferreira, Milene Silveira; Cardoso, Divina das Dôres de Paula

doi:10.1590/0037-8682-0425-2015

Cited by 21 publications

(16 citation statements)

References 8 publications

(12 reference statements)

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“…The emergence and re-emergence of OROV fever in Central and South America have resulted in more than 30 epidemics in Brazil, Peru, Panama, and Trinidad and Tobago, the majority being reported in Brazil, with disease prevalence to be 20% in both urban and rural human populations of the affected regions ( Figure 3 ) [ 46 , 47 , 48 ]. OROV is the second most frequent arbovirus in Brazil after dengue virus and among 200 different arboviruses isolated in this country [ 49 , 50 ], with considerable social and economic impact.…”

Section: Disease Epidemiologymentioning

confidence: 99%

“…OROV fever is manifesting as a self-limited, dengue-like, acute febrile illness that lasts 2–7 days, and is associated with a variety of symptoms such as fever, chills, headache, myalgia, arthralgia, malaise, dizziness, nausea, vomiting, photophobia, retro-ocular pain, and, in rare occasions, skin rash appearing more commonly on trunk and arms, hemorrhagic signs such as spontaneous bleeding, petechiae, epistaxis, gingival bleeding, and CNS signs like aseptic meningitis or meningoencephalitis [ 5 , 32 , 39 , 41 , 43 , 44 , 47 , 50 , 53 ]. In some patients, physical weakness and strength loss (asthenia) have been noticed for a period of 2–4 weeks [ 32 ].…”

Section: Clinical Manifestationsmentioning

confidence: 99%

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Oropouche Fever: A Review

Sakkas

Bozidis

Franks

et al. 2018

Viruses

101

137

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Oropouche fever is an emerging zoonotic disease caused by Oropouche virus (OROV), an arthropod transmitted Orthobunyavirus circulating in South and Central America. During the last 60 years, more than 30 epidemics and over half a million clinical cases attributed to OROV infection have been reported in Brazil, Peru, Panama, Trinidad and Tobago. OROV fever is considered the second most frequent arboviral febrile disease in Brazil after dengue fever. OROV is transmitted through both urban and sylvatic transmission cycles, with the primary vector in the urban cycle being the anthropophilic biting midge Culicoides paraensis. Currently, there is no evidence of direct human-to-human OROV transmission. OROV fever is usually either undiagnosed due to its mild, self-limited manifestations or misdiagnosed because its clinical characteristics are similar to dengue, chikungunya, Zika and yellow fever, including malaria as well. At present, there is no specific antiviral treatment, and in the absence of a vaccine for effective prophylaxis of human populations in endemic areas, the disease prevention relies solely on vector control strategies and personal protection measures. OROV fever is considered to have the potential to spread across the American continent and under favorable climatic conditions may expand its geographic distribution to other continents. In view of OROV’s emergence, increased interest for formerly neglected tropical diseases and within the One Health concept, the existing knowledge and gaps of knowledge on OROV fever are reviewed.

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Section: Disease Epidemiologymentioning

confidence: 99%

Section: Clinical Manifestationsmentioning

confidence: 99%

Oropouche Fever: A Review

Sakkas

Bozidis

Franks

et al. 2018

Viruses

101

137

View full text Add to dashboard Cite

show abstract

“…Before 2016, there were no reports of the occurrence of Oropouche fever in humans in Goiânia city, the State of Goiás, and central Brazil. But the OROV antibody has been found in NHPs in Goiânia city [ 17 ]. So, immunity development in NHPs against this OROV should be taken into consideration as a vital warning sign of ongoing virus circulation.…”

Section: Introductionmentioning

confidence: 99%

Immunoinformatics Approach for Epitope-Based Peptide Vaccine Design and Active Site Prediction against Polyprotein of Emerging Oropouche Virus

Adhikari

Tayebi

Rahman

2018

Journal of Immunology Research

114

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Oropouche virus (OROV) is an emerging pathogen which causes Oropouche fever and meningitis in humans. Several outbreaks of OROV in South America, especially in Brazil, have changed its status as an emerging disease, but no vaccine or specific drug target is available yet. Our approach was to identify the epitope-based vaccine candidates as well as the ligand-binding pockets through the use of immunoinformatics. In this report, we identified both T-cell and B-cell epitopes of the most antigenic OROV polyprotein with the potential to induce both humoral and cell-mediated immunity. Eighteen highly antigenic and immunogenic CD8+ T-cell epitopes were identified, including three 100% conserved epitopes (TSSWGCEEY, CSMCGLIHY, and LAIDTGCLY) as the potential vaccine candidates. The selected epitopes showed 95.77% coverage for the mixed Brazilian population. The docking simulation ensured the binding interaction with high affinity. A total of five highly conserved and nontoxic linear B-cell epitopes “NQKIDLSQL,” “HPLSTSQIGDRC,” “SHCNLEFTAITADKIMSL,” “PEKIPAKEGWLTFSKEHTSSW,” and “HHYKPTKNLPHVVPRYH” were selected as potential vaccine candidates. The predicted eight conformational B-cell epitopes represent the accessibility for the entered virus. In the posttherapeutic strategy, ten ligand-binding pockets were identified for effective inhibitor design against emerging OROV infection. Collectively, this research provides novel candidates for epitope-based peptide vaccine design against OROV.

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“…(Pinheiro et al 1962, 1976, Nunes et al 2005). Recently, active Oropouche virus surveillance in non-human primates in Brazil detected Oropouche virus in howler monkeys (i.e., Alouatta caraya ) (Gibrail et al 2016). We argue that similar studies should be conducted in Peru especially in the areas predicted of risk by our ecological models (Fig.…”

Section: Discussionmentioning

confidence: 99%

Vegetation loss and the 2016 Oropouche fever outbreak in Peru

Romero-Álvarez

Escobar

2017

Mem. Inst. Oswaldo Cruz

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BACKGROUND Oropouche virus causes Oropouche fever, an arboviral disease transmitted mainly by midges of the genus Culicoides and Culex mosquitoes. Clinical presentation of Oropouche fever in humans includes fever, headache, rash, myalgia, and in rare cases spontaneous bleeding and aseptic meningitis. Landscape change has been proposed as a driver of Oropouche fever emergence.OBJECTIVE To investigate the landscape epidemiology of the Oropouche fever outbreak that began in April 2016 in Cusco, Peru.METHODS We used information of vegetation and multivariate spatial analyses including ecological niche modeling. Vegetation was characterised using16-day composite enhanced vegetation index (EVI) images at 500 m spatial resolution from the MODIS sensor carried by the Terra satellite.FINDINGS Cases were distributed across seven Peruvian districts in two provinces. La Concepcion was the province with most of the affected districts. EVI time series across 2000 to 2016 suggested a decline in the vegetation in sites with Oropouche fever cases before the epidemic. Our ecological niche modeling suggests that other areas in Junin, Apurimac, and Madre de Dios departments are at risk of Oropouche fever occurrence.MAIN CONCLUSIONS Our results may provide a guide for future fieldwork to test hypotheses regarding Oropouche fever emergence and habitat loss in tropical Latin America.

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Detection of antibodies to Oropouche virus in non-human primates in Goiânia City, Goiás

Cited by 21 publications

References 8 publications

Oropouche Fever: A Review

Oropouche Fever: A Review

Immunoinformatics Approach for Epitope-Based Peptide Vaccine Design and Active Site Prediction against Polyprotein of Emerging Oropouche Virus

Vegetation loss and the 2016 Oropouche fever outbreak in Peru

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