Meningitis caused by Salmonella enterica serotype Panama in Brazil: first case reported

Carneiro, Maria Regina Pires; Patrício, Maria Iracema de Aguiar; Jain, Sona; Rodrigues, Dália dos Prazeres; Fracalanzza, Sérgio Eduardo Longo

doi:10.1590/0037-8682-0367-2017

Cited by 6 publications

(7 citation statements)

References 10 publications

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“…Furthermore, it is possible that a case of meningitis in an exclusively breastfed 4-month-old patient was contracted from breast milk that was contaminated with an antimicrobial-susceptible S . Panama isolate (41).…”

Section: Transmission Vehiclesmentioning

confidence: 99%

“…There are conflicting reports in the literature relating to the AMR status of the S . Panama serovar, with studies in Italy and Brazil reporting low levels of antibiotic resistance (41, 73). They are supported by further reports from Martinique, where 91% of S .…”

Section: Antimicrobial Resistancementioning

confidence: 99%

“…Panama, including the above-mentioned S . Panama ATCC 7378, does not commonly carry the large plasmids that have previously been associated with virulence in other Salmonella serovars (41). Rather, S .…”

Section: Invasive Disease—genomic Inferences In S Panamamentioning

confidence: 99%

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Salmonella enterica Serovar Panama, an Understudied Serovar Responsible for Extraintestinal Salmonellosis Worldwide

et al. 2019

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In recent years nontyphoidal Salmonella has emerged as one of the pathogens most frequently isolated from the bloodstream in humans. Only a small group of Salmonella serovars cause this systemic infection, known as invasive nontyphoidal salmonellosis. Here, we present a focused minireview on Salmonella enterica serovar Panama, a serovar responsible for invasive salmonellosis worldwide. S. Panama has been linked with infection of extraintestinal sites in humans, causing septicemia, meningitis, and osteomyelitis. The clinical picture is often complicated by antimicrobial resistance and has been associated with a large repertoire of transmission vehicles, including human feces and breast milk. Nonhuman sources of S. Panama involve reptiles and environmental reservoirs, as well as food animals, such as pigs. The tendency of S. Panama to cause invasive disease may be linked to certain serovar-specific genetic factors.

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Section: Transmission Vehiclesmentioning

confidence: 99%

Section: Antimicrobial Resistancementioning

confidence: 99%

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Salmonella enterica Serovar Panama, an Understudied Serovar Responsible for Extraintestinal Salmonellosis Worldwide

et al. 2019

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“…The plasmid complement of the S . Panama serovar has rarely been studied in the past, but it has been reported that S. Panama does not commonly carry the large virulence plasmids that have previously been characterised in other Salmonella serovars 16 . Rather, S. Panama have previously been found to carry a heterogeneous population of plasmids (Table S1) 17 .…”

Section: Resultsmentioning

confidence: 99%

Global diversity and evolution ofSalmonellaPanama, an understudied serovar causing gastrointestinal and invasive disease worldwide: a genomic epidemiology study

Pulford,

Perez-Sepulveda,

Ingle

et al. 2024

Preprint

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Background Nontyphoidal Salmonella (NTS) is a globally important bacterial pathogen, typically associated with foodborne gastrointestinal infection. Some NTS serovars can also colonise normally sterile sites in humans to cause invasive NTS (iNTS) disease. One understudied Salmonella enterica serovar which is responsible for a significant number of cases of iNTS disease is Panama. Despite global dissemination, numerous outbreaks, and a reported association with iNTS disease, S. enterica serovar Panama (S. Panama) has not been investigated in detail. Methods Using combined epidemiological and whole genome sequencing data we analysed 836 S. Panama isolates from all inhabited continents collected between 1931 and 2019. A combination of phylodynamic approaches were used to determine population structure & evolutionary history, and to infer geo-temporal dissemination. Subsequently, we characterised geographic and clade-specific trends in antimicrobial resistance (AMR), and genetic markers for invasiveness using epidemiological and bioinformatic approaches. Findings We identified the presence of multiple geographically linked S. Panama clades, and regional trends in antimicrobial resistance profiles. Most isolates were pan-susceptible to antibiotics and belonged to clades circulating in the United States of America, Latin America, and the Caribbean. Multidrug resistant (MDR) isolates belonged to two phylogenetic clades circulating in Europe and Asia/Oceania, which exhibited the highest invasiveness indices based on the conservation of 196 extra-intestinal predictor genes. Interpretation This first large-scale phylogenetic analysis of S. Panama revealed important information about population structure, AMR, global ecology, and genetic markers of invasiveness of the identified genomic subtypes. Our findings provide an important baseline for understanding S. Panama infection in the future. The presence of MDR clades with an elevated invasiveness index should be monitored by ongoing surveillance as such clades may pose an increased public health risk.

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“…Subsequent investigations, including CSF culture, revealed gram-negative bacilli that were sensitive to most antibiotics, including ampicillin, ceftriaxone, ceftazidime, chloramphenicol, and trimethoprim. Fortunately, the patient survived [ 11 ]. Another interesting study by Lakew et al described a 13-day-old neonate with Salmonella enterica meningitis; the patient had no remarkable prenatal, natal, or postnatal events.…”

Section: Discussionmentioning

confidence: 99%

Infant Salmonella enterica Meningitis: A Rare Case Report and Review of Literature

Ali,

Shareef,

Abdul Aziz

et al. 2024

Cureus

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Meningitis caused by Salmonella enterica can be a fatal condition that is more common in low- and middle-income countries and uncommon in infants. This case of a 2-month-old male infant reported Salmonella meningitis symptoms, such as fever, irritability, altered sensorium, and diarrhoea. Clinical examination revealed bulging anterior fontanelles, dehydration, and sunken eyes. Screening for normal hearing, cranial ultrasound, and magnetic resonance imaging (MRI) revealed no brain abnormalities. A cerebrospinal fluid (CSF) culture revealed gram-negative Salmonella enterica bacilli. Treatment with meropenem and ampicillin was initiated after antibiotic susceptibility testing showed sensitivity. The patient’s cerebrospinal fluid parameters and bacterial growth improved after antibiotic therapy. Two weeks later, the baby was neurologically healthy and discharged. Paediatricians should be aware that Salmonella enterica can cause meningitis in children with non-specific symptoms.

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Meningitis caused by Salmonella enterica serotype Panama in Brazil: first case reported

Cited by 6 publications

References 10 publications

Salmonella enterica Serovar Panama, an Understudied Serovar Responsible for Extraintestinal Salmonellosis Worldwide

Salmonella enterica Serovar Panama, an Understudied Serovar Responsible for Extraintestinal Salmonellosis Worldwide

Global diversity and evolution ofSalmonellaPanama, an understudied serovar causing gastrointestinal and invasive disease worldwide: a genomic epidemiology study

Infant Salmonella enterica Meningitis: A Rare Case Report and Review of Literature

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