Two cases of lepidopterism caused by indoor exposure to moths

Eyer-Silva, Walter de Araújo; Silva, Guilherme Almeida Rosa da; Neves-Motta, Rogério

doi:10.1590/0037-8682-0345-2015

Cited by 1 publication

(2 citation statements)

References 3 publications

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“…Such antivenom is used to address the intoxication by the extremely venomous Lonomia obliqua (Saturniidae) also known as Taturana or fire caterpillar in southern Brazil [ 5 , 6 ]. It is believed that the increase in lepidopterism incidence is caused by several environmental changes associated with anthropogenic activity including those produced by climate change [ 7 ]. the incidence of this affectation is related to the colonization and life cycle development of lepidopteran species in diverse monocultures that cause devastating losses [ 1 , 2 , 3 , 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…the incidence of this affectation is related to the colonization and life cycle development of lepidopteran species in diverse monocultures that cause devastating losses [ 1 , 2 , 3 , 4 , 5 , 6 ]. Dermatitis produced by these insects is usually resistant to all therapeutic treatments since their venom is considered a complex cocktail of inflammatory molecules [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

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1H NMR Profiling of the Venom from Hylesia continua: Implications of Small Molecules for Lepidopterism

Villa‐Ruano

Becerra‐Martínez

Cunill-Flores

et al. 2023

Toxins

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Lepidopterism caused by caterpillar contact is considered a public health problem around the world. The local and systemic responses of this pathology include short- and long-term inflammatory events. Although the proteolytic activity of the venoms from caterpillars is strongly associated with an inflammatory response in humans and murine models, fast and acute symptoms such as a burning sensation, itching, and pain should be related to the presence of low-weight hydrophilic molecules which easily influence cell metabolism. This investigation reports on the 1H-Nuclear Magnetic Resonance (NMR) profiling of the venom from the larva of Hylesia continua, a caterpillar linked to frequent cases of lepidopterism in the northern highlands of Puebla, Mexico. According to one-dimensional (1D) and two-dimensional (2D) NMR data, the venom of H. continua contained 19 compounds with proven pain-inducing activity (i.e., acetic acid, lactic acid, formic acid, succinic acid, 2-hydroxyglutaric acid, ethanol, and glutamate), inflammatory activity (i.e., cadaverine, putrescine, and acetoin), as well as natural immunosuppressive activity (i.e., O-phosphocholine and urocanic acid). The levels of the 19 compounds were calculated using quantitative-NMR (qNMR) and extensively discussed on the basis of their toxic properties which partially explain typical symptoms of lepidopterism caused by the larvae of H. continua. To the best of our knowledge, this is the first investigation reporting a complex mixture of small molecules with inflammatory properties dissolved in the venom of a lepidopteran larva.

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