Clinical, demographic, and epidemiologic characteristics of hepatitis B virus-infected patients at a tertiary public hospital in Presidente Prudente, State of São Paulo, Brazil

Prestes-Carneiro, Luiz Euribel; Vieira, Jessyka Thaiza Menezes; Isaac, Luiza Bellintani; Filho, Alexandre Martins Portelinha

doi:10.1590/0037-8682-0315-2015

Cited by 4 publications

(4 citation statements)

References 16 publications

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“…[19] In the western region, all inmates diagnosed with HIV are treated and are followed by specialists in reference centers in Presidente Prudente. [20-21] Prevalence of 1.8% was detected in a prison in São Paulo state. [7] In a prospective study of 3,362 inmates from 12 prisons in the central-west region of Brazil in 2013, a prevalence of 1.6% was found.…”

Section: Discussionmentioning

confidence: 99%

The Changing Landscape: Geospatial, Epidemiologic Characteristics and Infectious Diseases of Inmates Living in a Region with a High Number of Prisons, Brazil

Giuffrida

et al. 2020

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Objective: We determined the geospatial and epidemiologic characteristics and prevalence of HIV, tuberculosis, viral hepatitis, syphilis, and co-infections in inmates in 28 prisons. Design: This is a regional, observational, retrospective, and descriptive study conducted from November 2017 to October 2018. Setting Prisons are located in the western and northwestern regions of Sao Paulo state, Brazil. Methods: Data were obtained through a standard questionnaire from inmates with a diagnosis of infectious diseases and co-infections (HIV, hepatitis B virus, hepatitis C virus, syphilis, and tuberculosis), treatment, and time of incarceration. Locations of prisons and highways were obtained from shape file databases. Data on inhabitants, population growth, and Human Development Index were obtained from public agencies. Maps were constructed using geographic information system. Results: A total of 37,497 individuals were enrolled in the study and 741 (1.97%) were diagnosed. HIV was the most prevalent disease (0.68%), followed by tuberculosis (0.66%), syphilis (0.2%), HCV (0.2%), and HBV (0.04%). HIV-syphilis was the most prevalent co-infection (odds ratio, 63.7; 95% confidence interval: 41.4, 96.7). There was a statistical significance (P<0.001) for those with HIV acquiring co-infections. In 21 units, there was no relationship between the number of prisoners and the prevalence of infectious diseases.Mean age was 35.82 years (SD, 10.41 years) and 57.9% had been in prison previously. Strategically, most prisons were constructed beside radial highways. A higher than expected population growth was observed in 17 municipalities in which prisons were constructed (47.2%). Conclusions: This is one of the biggest studies in Brazil, and the prevalence of infectious diseases among inmates was lower than countrywide. Therefore, improvements in health care are necessary, mainly in screening for infectious diseases. Construction of large prisons beside the radial highways changed the landscape and prevented migration of people from small to large cities.

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Section: Discussionmentioning

confidence: 99%

The Changing Landscape: Geospatial, Epidemiologic Characteristics and Infectious Diseases of Inmates Living in a Region with a High Number of Prisons, Brazil

Giuffrida

et al. 2020

Preprint

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“…The average lethality rate for the entire country was 6.5% in 2000-2010 [28-29]. The importance of tertiary hospitals in Brazil in the context of SUS is overwhelming with regard to both short hospital stay and low lethality rates [7,9]. The classic signs and symptoms of the disease worldwide (discrete splenomegaly, hepatomegaly, fever, and pallor) were present in almost all the infants [1,2].…”

Section: Discussionmentioning

confidence: 99%

“…Tertiary public hospitals play a key role in the Unified Public Health System (SUS) throughout Brazil. They support smaller hospitals and perform more complex treatment procedures [7,9]. Our aim was to evaluate the clinical characteristics and spatial distribution of VL in children referred to a public tertiary hospital located in the western region of São Paulo state, an emerging focus of VL in Brazil.…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics and spatial distribution of Visceral leishmaniasis in children in São Paulo state: an emerging focus of Visceral leishmaniasis in Brazil

Spir

Prestes-Carneiro

Fonseca

et al. 2017

Pathogens and Global Health

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The short interval between the onset of symptoms, diagnosis, and treatment and the reduced number of days of hospitalization certainly influenced the small number of deaths, relapses, and severity among the children infected with VL. However, the disease is spreading fast in the western region of São Paulo state. Thus, integrated actions and effective monitoring of the disease are needed to complement curative practices.

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“…In 2019, the estimated population was 228,743 inhabitants (IBGE) [ 13 ]. The Regional Hospital of Presidente Prudente (RH), located in Presidente Prudente, is a 550-bed tertiary-care public university hospital providing care for SUS patients, and since 2000, it has been a reference center for the diagnosis and treatment of viral hepatitis caused by HBV and HCV [ 14 ]. From January 2000 to December 2013, a percentage of patients diagnosed with chronic HCV in municipalities of RHAN11 were referred to the infectious disease’s outpatient clinics of RH and others were diagnosed and treated in settings such as private clinics and public health care centers.…”

Section: Methodsmentioning

confidence: 99%

Clinical, Epidemiological, and Geospatial Characteristics of Patients Infected with Hepatitis C Virus Treated with Second-Generation Direct-Action Antivirals in a Reference Center in a Mesoregion of São Paulo State, Brazil

et al. 2020

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Hepatitis virus infection is a major public health problem worldwide. Currently, Brazil has almost 700,000 cases. The Brazilian Unified Health System (SUS) provides therapeutic regimens for people infected with hepatitis C virus (HCV). We determined the clinical, laboratory, epidemiologic, and geospatial characteristics of patients infected with HCV treated with second-generation direct-action antivirals (DAAs) in a hospital reference center in São Paulo state, Brazil, using data from file records. A map was constructed using a geographic information system. From 2015 to 2018, 197 individuals received second-generation DAAs (mean age, 57.68 ± 1.36 years; interquartile range, 56.22–59.14 years; 58.9% male; 41.1% female). Genotypes 1a and 1b accounted for 75.7% of cases and the prevalent therapeutic regimen was sofosbuvir/simeprevir. Sustained viral response accounted for 98.9% and the METAVIR score F3/F4 for 50.8%. Increased alanine transferase was significantly correlated with an increase in α-fetoproteins (p = 0.01), and severe necro-inflammatory activity (p = 0.001). Associated comorbidities were found in 71.6%, mainly coronary artery and gastrointestinal disorders. The cumulative incidence in the region was 2.6 per 10,000 inhabitants. Our data highlight the role of reference hospitals in Brazil’s public health system in the treatment of HCV. Low incidence rates demonstrated the fragility of municipalities in the active search for patients.

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Clinical, demographic, and epidemiologic characteristics of hepatitis B virus-infected patients at a tertiary public hospital in Presidente Prudente, State of São Paulo, Brazil

Cited by 4 publications

References 16 publications

The Changing Landscape: Geospatial, Epidemiologic Characteristics and Infectious Diseases of Inmates Living in a Region with a High Number of Prisons, Brazil

The Changing Landscape: Geospatial, Epidemiologic Characteristics and Infectious Diseases of Inmates Living in a Region with a High Number of Prisons, Brazil

Clinical characteristics and spatial distribution of Visceral leishmaniasis in children in São Paulo state: an emerging focus of Visceral leishmaniasis in Brazil

Clinical, Epidemiological, and Geospatial Characteristics of Patients Infected with Hepatitis C Virus Treated with Second-Generation Direct-Action Antivirals in a Reference Center in a Mesoregion of São Paulo State, Brazil

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