Spatiotemporal analysis of reported cases of acute Chagas disease in the State of Pernambuco, Brazil, from 2002 to 2013

Santos, Fred Luciano Neves; Lorena, Virgínia Maria Barros de; Souza, Wayner Vieira de; Gomes, Yara de Miranda

doi:10.1590/0037-8682-0312-2014

Cited by 4 publications

(4 citation statements)

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“…However, as previously mentioned, the Southern Cone Initiative has changed the epidemiological profile of the disease, as the country has received international certification for the interruption of vectorial transmission by T. infestans in 2006. In fact, a study carried out in Pernambuco state showed a significant decrease in new cases starting in 2006 [ 25 ]. Because of the decrease in vectorial transmission in Brazil, attention should be directed to the new cases that occur through contaminated food and beverages in endemic areas [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

“…Knowledge of the distribution of NTDs in endemic areas is fundamental to the follow-up and assessment of interventions and the effectiveness of control measures. Attention has recently turned to epidemiological studies considering the spatial distribution of NTDs in the general population [ 25 – 28 ]. Owing to the scarcity of information describing NTDs in Brazilian children and adolescents, the epidemiological aspects and distribution of visceral and cutaneous leishmaniasis, acute Chagas disease, malaria, and schistosomiasis in individuals aged up to 19 years reported in the Health Notification Aggravation Information System (SINAN) database from 2009 to 2013 were assessed.…”

Section: Introductionmentioning

confidence: 99%

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Neglected tropical diseases in Brazilian children and adolescents: data analysis from 2009 to 2013

et al. 2017

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BackgroundNeglected tropical diseases (NTDs) prevail in conditions of poverty and contribute to the maintenance of social inequality. Out of the NTDs prioritized by the Brazilian Ministry of Health, four parasitic infections require mandatory notification: acute Chagas disease, leishmaniasis, malaria, and schistosomiasis. Data on the behaviour of these NTDs in the young population are currently limited. This study seeks to analyse the epidemiological aspects of these parasitic infections in children and adolescents in Brazil.MethodsA retrospective exploratory ecological study was conducted. A spatial analysis of the cases reported between 2009 and 2013 in individuals aged between 0 and 19 years that were notified through the Health Notification Aggravation Information System (SINAN) was performed.ResultsIn total, 64,567 cases of cutaneous and visceral leishmaniasis, malaria, schistosomiasis, and acute Chagas disease were recorded in the SINAN database, representing a rate of 20.15 cases per 100,000 inhabitants. The average age of the cases was 12.2 years and 62.32% were male. Four hundred and three deaths related to these obligatorily reported parasites were recorded, indicating a case fatality rate of 0.62%. Visceral leishmaniasis and acute Chagas disease had the highest rates of lethality. A heterogeneous spatial distribution of the studied parasites was observed.ConclusionsThe number of cases and the lethality rate described in this study show that these diseases still represent a serious problem for public health in Brazil. This points to the need to encourage new research and the reformulation of social, economic, and public health policies aimed at ensuring better health and living conditions for all individuals, especially those among the populations considered vulnerable, as is the case of the young.Electronic supplementary materialThe online version of this article (10.1186/s40249-017-0369-0) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neglected tropical diseases in Brazilian children and adolescents: data analysis from 2009 to 2013

et al. 2017

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“…The present study found a high number of cases among individuals of productive age (15–59 years), suggesting increased frequency of exposure in this population due to occupational activities that increase the risk of transmission [ 23 ]. In the Brazilian Northeast macroregion, this age group was associated with a high number of cases arising from vectorial transmission, possibly due to frequent triatomine exposure of this rural population during work-related activities [ 24 – 26 ]. This finding is relevant as morbidity and mortality in acute CD is directly associated with reduced quality of life in infected individuals.…”

Section: Discussionmentioning

confidence: 99%

Acute Chagas disease in Brazil from 2001 to 2018: A nationwide spatiotemporal analysis

et al. 2020

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Background In Brazil, acute Chagas disease (ACD) surveillance involves mandatory notification, which allows for population-based epidemiological studies. We conducted a nationwide population-based ecological analysis of the spatiotemporal patterns of ACD notifications in Brazil using secondary surveillance data obtained from the Notifiable Diseases Information System (SINAN) maintained by Brazilian Ministry of Health. Methodology/Principal findings In this nationwide population-based ecological all cases of ACD reported in Brazil between 2001 and 2018 were included. Epidemiological characteristics and time trends were analyzed through joinpoint regression models and spatial distribution using microregions as the unit of analysis. A total of 5,184 cases of ACD were recorded during the period under study. The annual incidence rate in Brazil was 0.16 per 100,000 inhabitants/year. Three statistically significant changes in time trends were identified: a rapid increase prior to 2005 (Period 1), a stable drop from 2005 to 2009 (Period 2), followed by another increasing trend after 2009 (Period 3). Higher frequencies were noted in males and females in the North (all three periods) and in females in Northeast (Periods 1 and 2) macroregions, as well as in individuals aged between 20–64 years in the Northeast, and children, adolescents and the elderly in the North macroregion. Vectorial transmission was the main route reported during Period 1, while oral transmission was found to increase significantly in the North during the other periods. Spatiotemporal distribution was heterogeneous in Brazil over time. Despite regional differences, over time cases of ACD decreased significantly nationwide. An increasing trend was noted in the North (especially after 2007), and significant decreases occurred after 2008 among all microregions other than those in the North, especially those in the Northeast and Central-West macroregions. Conclusions/Significance In light of the newly identified epidemiological profile of CD transmission in Brazil, we emphasize the need for strategically integrated entomological and health surveillance actions.

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“…In the present study, there was a high rate of T. cruzi oral transmission, and it has become increasingly frequent in this region, when compared to previous research. In other regions, where oral transmission by T. cruzi is less frequent, for example, in the state of Pernambuco, this route of transmission has significantly decreased after 2006, a period in which Brazil received an international certificate for interrupting vector transmission by Triatoma infestans 24 .…”

Section: Discussionmentioning

confidence: 99%

Epidemiological profile of acute Chagas disease in individuals infected by oral transmission in northern Brazil

Sampaio

Silva

Brito

et al. 2020

Rev. Soc. Bras. Med. Trop.

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Introduction: Oral infection by Trypanosoma cruzi is currently the most important route of transmission of acute Chagas disease (ACD) in the North region of Brazil, and the reported outbreaks are usually related to ingestion of contaminated food, especially unprocessed açaí pulp. Methods: A retrospective cohort study was performed to analyze the epidemiological profile of individuals with suspected cases of ACD in the municipality of Breves, located in the state of Pará, Brazil. Therefore, notifications of suspected cases of ACD were collected from the Municipal Health Department of Breves from January 2007 to December 2017. Results: A total of 265 individuals were registered, and the majority were male (54.7%; 145/265). Age ranged from nine months to 79 years, with a greater number of notifications for individuals aged between 1 and 39 years (71.3%; 189/265). Most of them had a low level of education (74.3%, 197/265), were living in rural and urban areas (58.9%; 156/265 and 37.7%; 100/265, respectively). Infection occurred mainly in the domestic environment (96.2%; 255/265) through oral transmission (98.1%; 260/265). There were a greater number of notifications in November, December and January. Conclusions: These data showed that oral transmission of T. cruzi has become increasingly high in the study region, and health education programs need to be implemented as strategies to ensure good manufacturing practices of unprocessed food.

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Spatiotemporal analysis of reported cases of acute Chagas disease in the State of Pernambuco, Brazil, from 2002 to 2013

Cited by 4 publications

References 18 publications

Neglected tropical diseases in Brazilian children and adolescents: data analysis from 2009 to 2013

Neglected tropical diseases in Brazilian children and adolescents: data analysis from 2009 to 2013

Acute Chagas disease in Brazil from 2001 to 2018: A nationwide spatiotemporal analysis

Epidemiological profile of acute Chagas disease in individuals infected by oral transmission in northern Brazil

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