Depressive symptoms and harmful alcohol use in hepatitis C patients: prevalence and correlates

Machado, Danusa de Almeida; Silva, Giovanni Faria; Torres, Albina Rodrigues; Ramos-Cerqueira, Ana Teresa de Abreu

doi:10.1590/0037-8682-0270-2013

Cited by 9 publications

(5 citation statements)

References 36 publications

(54 reference statements)

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“…HCV infection is also associated with psychiatric disorders, including alcohol abuse, drug abuse, and depression. [ 27 ] Findings from the National Health and Nutrition Examination Survey (NHANES 2005–2010) showed that only chronic hepatitis C, but not chronic hepatitis B, alcohol-related liver disease, or nonalcoholic fatty liver disease, was strongly associated with depression. [ 28 ] The prevalence of depressive symptoms among patients with HCV infection was found to be between 21% and 58.6%.…”

Section: Discussionmentioning

confidence: 99%

Association of anxiety and depression with chronic liver diseases in patients with noncardiac chest pain: A cross-sectional study

Chang

Ho²,

Tsai

et al. 2022

Medicine

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Causes of chest pain can vary from benign to life-threatening conditions, and in many cases not necessary of cardiac origin. A possible reason for noncardiac chest pain could be anxiety or depression caused by chronic liver diseases. The aim of this study was to investigate the association of anxiety and depression with chronic liver disease in patients with noncardiac pain.Patients with chest tightness or pain referred for treadmill exercise testing were recruited from a regional hospital in southern Taiwan. Medical records of the patients were used to define the presence and type of chronic liver disease. Multiple logistic regression analyses were conducted to assess the association of anxiety and depression with chronic liver disease.A total of 2537 patients with liver function test results and abdominal sonography data were analyzed, and 1965 patients showed a negative treadmill exercise testing. The mean age of these 1965 patients was 51.9 years and 54.2% were male. The prevalence of alcoholic liver disease, hepatitis B, hepatitis C, and fatty liver disease was 10.6%, 10.9%, 3.7%, and 27.0%, respectively. Results from multiple logistic regression analyses showed that the risk of anxiety (adjusted odds ratio [aOR] = 1.83, P < .001) and depression (aOR = 1.85, P < .001) was significantly higher in patients with alcoholic liver disease. Anxiety was significantly higher in patients with fatty liver disease (aOR = 1.30, P = .031), and the risk of depression was significantly higher in patients with chronic hepatitis C (aOR = 2.18, P = .005).In conclusion, in patients with noncardiac chest pain, alcoholic liver disease was significantly associated with anxiety and depression, while those with fatty liver and chronic hepatitis C were associated with anxiety and depression, respectively. Clinicians should be vigilant to these correlations in their practice.

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Section: Discussionmentioning

confidence: 99%

Association of anxiety and depression with chronic liver diseases in patients with noncardiac chest pain: A cross-sectional study

Chang

Ho²,

Tsai

et al. 2022

Medicine

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“…In the full model for pain‐related drinking motives, depression approached significance with a p = .052, HR = 2.47. Given that both mental illness and alcohol use are disproportionately high among patients with HCV, it is likely that alcohol use serves as a form of self‐medication for depression, anxiety or trauma histories in this population; at a minimum, there is a complex link between these comorbidities 21,29 …”

Section: Discussionmentioning

confidence: 99%

Why do patients with chronic hepatitis C drink alcohol? An examination of pain, depression and drinking motives

Wilder

Evon

Proeschold‐Bell

et al. 2021

Journal of Viral Hepatitis

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Alcohol consumption in the setting of chronic HCV is associated with accelerated progression towards cirrhosis, increased risk of hepatocellular carcinoma and higher mortality. This analysis contextualizes how sociodemographic factors, chronic pain and depression relate to the motivations of individuals with chronic HCV to consume alcohol. We conducted a secondary analysis of baseline data from the Hep ART trial of behavioural interventions on alcohol use among patients with HCV. Alcohol consumption was measured using the Drinking Motives Questionnaire and a novel 6-item measure of pain-related drinking motives. Statistical analyses performed included ANOVA for bivariate analyses and multivariable ordinary least-squares linear regression. At study baseline, 181 participants had an average age of 55 years; the majority (66.7%) reported beyond-minor pain; and a third (37%) met criteria for depression; drinking motives were higher for individuals with beyond-minor pain (means 9.9 vs. 4.6, p < .001) and who met criteria for depression (means 10.9 vs. 6.4, p < .001) when using the pain-related drinking motives items. Average pain(coef = 1.0410067141 < .001) was significantly associated with increased motives to drink to relieve pain in the full baseline model specification controlling for all covariates using ordinary at least squares; depression (coef = 7.06; 95% CI 1.32, 12.81; p = .016) was significantly associated with increased non-pain-related motives to drink. From baseline to 3-month followup, compared to participants who had mean average pain scores among the sample, motives to drink to relieve pain decreased in participants who had higher average pain scores (coef = −0.30; 95% CI −0.59, −0.01; p = .40). Physical pain and depression are associated with increased motives to consume alcohol. Patients with chronic liver disease should be screened for chronic pain and depression and, if present, referred to pain specialists or co-managed in partnership with pain specialists in hepatology clinics.

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“…Patients suffering from either HBV or HCV are at high-risk of having depression and psychosocial issues. These include anxiety, depressed mood, reduced self-esteem and confidence, disturbed sleep and a loss of appetite (Machado et al, 2014). Due to the adverse effect of the illness, in the form of augmentation of physical symptoms, functional impairments and reduced compliance of treatment and reduced quality of life.…”

Section: What Is Liver Disease?mentioning

confidence: 99%

Early Intervention and Health Promotion in the Management of Chronic Liver Disease

Hussain

2018

International Journal of User-Driven Healthcare

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Liver disease is prevalent and a major public health concern. It has predominantly spread in the UK and worldwide, causing liver-related morbidity and mortality rates for the under 65s since 1970. This article aims to highlight the role of early intervention and health promotion in the management of chronic liver disease (CLD). The objective is to critically analyse an issue like CLD, and further employ principles, ethical theories to health promotion practice. Since 2015, there is no one single drug that treats NALFD, a dietary plan and lifestyle modifications can be added in management of the disease. Educating patients perhaps is a form of regimen, and a coping mechanism as set by the health belief model to understand the disease. Additional studies need to be formed to understand the exact contributions health care professionals are likely to make, and of those that are new clinicians.

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Depressive symptoms and harmful alcohol use in hepatitis C patients: prevalence and correlates

Cited by 9 publications

References 36 publications

Association of anxiety and depression with chronic liver diseases in patients with noncardiac chest pain: A cross-sectional study

Association of anxiety and depression with chronic liver diseases in patients with noncardiac chest pain: A cross-sectional study

Why do patients with chronic hepatitis C drink alcohol? An examination of pain, depression and drinking motives

Early Intervention and Health Promotion in the Management of Chronic Liver Disease

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