Prevalence and factors associated with lipodystrophy in AIDS patients

Justina, Lunara Basqueroto Della; Luiz, Magali Chaves; Silva, Rosemeri Maurici da; Schuelter-Trevisol, Fabiana

doi:10.1590/0037-8682-0240-2013

Cited by 13 publications

(15 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regarding the type of lipodystrophy, we observed that lipoatrophy was present in 37.8% of the patients, mainly in men (75%), followed by mixed lipodystrophy in 31.8% of the patients, 65.9% were men and the least frequent was lipohypertrophy, present in 30.4% of the patients, most of whom were male (65.9%). Our results are different from those reported by Justina et al (2014), who found greater prevalence of lipoatrophy (62.5%), and a lower frequency of lipohypertrophy (8.3%) and mixed lipodystrophy (29.2%). The variation in the frequency of lipodystrophy may also be due to a lack of standards to determine it, and the use of autoperception by the subject; also the diagnosis by the researcher could be subjective, even though it has been described in a publication (Loonam and Mullen, 2012).…”

Section: Discussioncontrasting

confidence: 99%

“…However, Highly Active Antiretroviral Therapy (HAART) has turned a fatal into a chronic disease; but it has numerous side effects, including lipodystrophy syndrome (Montessori et al, 2004;Merck Manual, 2018), which is characterized by abnormal fat deposition and metabolic changes (Paton et al, 2002). Changes in fat deposition may result in lipoatrophy, reduction in facial, gluteal and member fat; lipohipertrophy and fat accumulation in the abdomen, neck and thorax, and mixed lipodystrophy, which is a combination of both (Justina et al, 2014). Metabolic changes can include an increase in triglycerides, total cholesterol, LDL-cholesterol, hyperglycemia and reduction in HDLcholesterol (Simha, 2014).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Research Article CCR5Δ32 polymorphism analysis of lipodystrophy syndrome development in HIV/AIDS patients

Santos¹,

Alves²,

Tenório³

et al. 2019

Genet. Mol. Res.

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Research Article CCR5Δ32 polymorphism analysis of lipodystrophy syndrome development in HIV/AIDS patients

Santos¹,

Alves²,

Tenório³

et al. 2019

Genet. Mol. Res.

View full text Add to dashboard Cite

show abstract

“…This disease is most likely a result of the interaction between antiretroviral therapy, virus infection, genetic factors, and the lifestyle of the individual. 32 …”

Section: Discussionmentioning

confidence: 99%

<p>Dyslipidemia and Associated Factors Among Adult Patients on Antiretroviral Therapy in Armed Force Comprehensive and Specialized Hospital, Addis Ababa, Ethiopia</p>

Kemal¹,

Teshome²,

Ahmed³

et al. 2020

HIV

View full text Add to dashboard Cite

Background: The development of antiretroviral drugs and subsequent access to combined antiretroviral therapy contributed to the decline in morbidity and mortality rates associated with acquired immune deficiency syndrome, resulting in an increased life expectancy and improved quality of life for people living with human immunodeficiency virus. However, a cluster of metabolic derangements such as dyslipidemia is increasing, especially for those on antiretroviral therapy. Limited studies were done on the prevalence of dyslipidemia and its associated factors among adult patients on antiretroviral therapy in Ethiopia which demand the conduct of the present investigation entitled on the prevalence of dyslipidemia and its associated factors among adult patients on antiretroviral therapy in Armed Force Comprehensive and Specialized Hospital Addis Ababa, Ethiopia, 2018. Methods: Institution-based cross-sectional study design was employed between March and April 2018. Systematic sampling method was used to select 353 study participants. Pretested stepwise approach of the World Health Organization questionnaire (WHO Stepwise), document review, anthropometric measurements, and laboratory analysis were used to collect data on different variables under the study. Collected data were entered in Epidata version 3 and analyzed by SPSS version 21. Results: The prevalence of dyslipidemia among study participants was 74.8%. Female participants were twice and half at risk of developing dyslipidemia compared to males (AOR= 2.38; 95% CI: 1.15, 3.66). Similarly, compared to those attended college level of education, not attended formal education (AOR=0.19; 95% CI: 0.05, 0.66), and having primary/secondary educational level (AOR= 0.33; 95% CI: 0.16, 0.66) showed lower odds to develop dyslipidemia. Furthermore, WHO clinical stage II (AOR= 0.35; 95% CI: 0.14,0.92), stage III (AOR=0.25; 95% CI:0.10,0.64), duration on ART (AOR= 1.01; 95% CI: 1.001,1.02), and BMI (AOR =1.13; 95% CI: 1.06,1.23) were significantly associated with dyslipidemia. Conclusion: There exists a high prevalence of dyslipidemia among study participants. Sex, educational status, WHO clinical stage, duration on ART, and BMI were significantly associated factors for dyslipidemia. Intervention strategies including the identified factors are demanded in the setting.

show abstract

“…Out of 84 potentially eligible studies, 45 were included in this review [37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80]. The search strategy and reasons for exclusion are shown in Figure 1.…”

Section: Study Selectionmentioning

confidence: 99%

Physical activity correlates in people living with HIV/AIDS: a systematic review of 45 studies

Vancampfort

Mugisha

Richards

et al. 2017

Disability and Rehabilitation

View full text Add to dashboard Cite

The current review has elucidated that participation in physical activity by people with HIV/AIDS is associated with a range of complex factors which should be considered in rehabilitation programs. Implications for Rehabilitation Health care professionals should consider HIV-related bodily pain and feelings of depression when assisting people living with HIV in inititiating and maintaining an active lifestyle. Interventions to improve self-efficacy and motivation, and to help people living with HIV in understanding the benefits of exercise, may encourage greater participation.

show abstract

Prevalence and factors associated with lipodystrophy in AIDS patients

Cited by 13 publications

References 42 publications

Research Article CCR5Δ32 polymorphism analysis of lipodystrophy syndrome development in HIV/AIDS patients

Research Article CCR5Δ32 polymorphism analysis of lipodystrophy syndrome development in HIV/AIDS patients

<p>Dyslipidemia and Associated Factors Among Adult Patients on Antiretroviral Therapy in Armed Force Comprehensive and Specialized Hospital, Addis Ababa, Ethiopia</p>

Physical activity correlates in people living with HIV/AIDS: a systematic review of 45 studies

Contact Info

Product

Resources

About