Noncontiguous multiple-level brucellar spondylodiscitis with an epidural abscess

Tekin, Recep; Çevik, Remzi; Nas, Kemal

doi:10.1590/0037-8682-0228-2015

Cited by 6 publications

(3 citation statements)

References 3 publications

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“…The initial hypothesis was confirmed, and the results revealed a positive correlation between irisin levels and blood culture, as well as a positive correlation between irisin levels and ALT levels in brucellosis patients. Blood cultures are considered the gold standard for diagnosing brucellosis [13][14][15][16][17]. However, in endemic areas, these laboratory…”

Section: Discussionmentioning

confidence: 99%

Investigation of new inflammatory biomarkers in patients with brucella

Canpolat Erkan,

Tekin

2024

PLoS ONE

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Background Delayed diagnosis and inadequate treatment of infectious and inflammatory diseases, such as Brucella, lead to high rates of mortality and morbidity. The aim of our study was to investigate the association between serum levels of apelin, presepsin, and irisin with inflammation, laboratory parameters, and blood culture in patients with brucella. Patients and methods This prospective case-control study involves 30 patients with brucellosis and 30 healthy, matched control subjects. Thirty patients who were diagnosed with brucellosis were aged ≥ 18 years. Blood samples were taken from the patients on the first day they were diagnosed with brucellosis. The values of irisin, presepsin, and apelin were studied. In addition, blood samples were also taken from 30 healthy individuals for the control group. Irisin, presepsin, and apelin values that were measured in the patients on the first day were compared with those values measured in the control group. Results The sex and age statuses of the subjects are matched among the groups. The levels of irisin were significantly higher in patients with brucellosis compared to the control group (p<0.045). There was no significant difference between the two groups in terms of apelin and presepsin levels (p values 0.087 and 0.162, respectively). There was a positive correlation between irisin levels and elevated ALT levels, as well as positive blood cultures. Conclusions It appears that the measurement of irisin levels may be beneficial in patients with brucellosis. Irisin can be used as a diagnostic marker for brucella infection and may greatly clinicians to predict the severity disease and treatment response.

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Section: Discussionmentioning

confidence: 99%

Investigation of new inflammatory biomarkers in patients with brucella

Canpolat Erkan,

Tekin

2024

PLoS ONE

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“…(A) the midsagittal magnetic resonance imaging revealed increased signal intensity (arrows) involving the T2-T3, T8-9, T11-12, and L4-5 disks and vertebral bodies. (B) Pathologic signal changes were identified, compatible with a 14 × 8-mm paraspinal abscess (L5), with low signal intensity on T1-weighted images, high signal intensity on T2-weighted images, and post-contrast peripheral enhancement (arrow) [3].…”

Section: Requirements For Preclinical Models Of Brucellar Spondylodiscitismentioning

confidence: 99%

Preclinical Models of Brucellar Spondylodiscitis

Cai¹,

Xu²,

Maimaiti³

et al. 2022

Preclinical Animal Modeling in Medicine

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Brucellar spondylodiscitis, the most prevalent and significant osteoarticular presentation of human Brucellosis, is difficult to diagnose and usually yields irreversible neurologic deficits and spinal deformities. Relevant aspects of Brucella pathogenesis have been intensively investigated in preclinical models. Mice, rats, rabbits, and sheep are representing available models to induce Brucellosis. Evaluation of Brucellar spondylodiscitis may be performed using a large variety of methods, including plain radiography, computed tomography, magnetic resonance imaging, histological analysis, blood test, and bacteria culture. This chapter focuses on these preclinical models of Brucellar spondylodiscitis. The requirements for preclinical models of Brucellar spondylodiscitis, pearls and pitfalls of the preclinical model establishment, and comprehensive analyses of Brucellar spondylodiscitis in animals are also depicted.

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“…8 Spinal surgery can facilitate the process of discitis via damaging the lower and upper vertebral endplates following disc space curettage, direct introduction of germs, and instability. 18 The most common causes of postoperative discitis are nosocomial infections and direct inoculation during surgery. 13 PS can also originate from a distant infection, for example, endocarditis, abscess, urinary tract infection, pneumonia, or pelvic infection.…”

Section: Introductionmentioning

confidence: 99%

Multiple Noncontiguous Spondylodiscitis Following Mastectomy Secondary to Breast Carcinoma: Case Report and Literature Review

Hasan

ALi

Al-Jasim

et al. 2021

Egyptian Spine Journal

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Background Data: Multiple noncontiguous spontaneous pyogenic spondylodiscitis is rare and has only been explained in the literature by case reports and case series. Purpose: We present a case report of multiple noncontiguous spontaneous spondylodiscitis caused by E. coli involving the cervical and lumbar spine following a mastectomy for breast cancer. We will explain the difficulties in diagnosis, treatment, and follow-up with the concomitant. Study Design: A case report and literature review. Case Report: A middle-aged patient with a history of breast carcinoma underwent surgery. Two weeks after mastectomy, the patient developed severe cervical and lumbar spine pain and a low-grade fever (37.5-38.3 °C). Moreover, neurological examination revealed a right-sided antalgic gait, right-sided weakness, and a positive straight leg raising test. Upon presentation, elevated C-reactive protein (CRP) and white blood cells (WBC) were noted. Magnetic resonance imaging (MRI) showed consistent spondylodiscitis at C5-C6 and L3-L4 levels with stenotic features at L4-L5 levels. Surgical treatment of the lumbar region via posterior spinal instrumentation from L3 to L5 levels and decompression was done with a biopsy. Erythrocyte sedimentation rate (ESR) CRP titers were also performed for the follow-up plan, which showed a reduction in 3, 6, and 12 weeks postoperatively. Conservative treatment of the cervical region was undertaken with a complete cure. Conclusion: Multiple noncontiguous spondylodiscitis after nonspinal surgery is a relatively rare complication requiring a high suspicion index. Surgery is recommended in case of failure of conservative measures, neurological deficit, or mechanical instability as in this case. Furthermore, both clinical examination and blood tests should be used to assess the treatment outcomes. (2021ESJ246)

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Noncontiguous multiple-level brucellar spondylodiscitis with an epidural abscess

Cited by 6 publications

References 3 publications

Investigation of new inflammatory biomarkers in patients with brucella

Investigation of new inflammatory biomarkers in patients with brucella

Preclinical Models of Brucellar Spondylodiscitis

Multiple Noncontiguous Spondylodiscitis Following Mastectomy Secondary to Breast Carcinoma: Case Report and Literature Review

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