Anti-Hepatitis B Antibody Levels In Immunized Medical Students: Are They At Risk?

Abstract

Introduction: Medical students have an occupational risk for hepatitis B (HB). This study sought to determine anti-HBs and anti-HBc IgG levels in vaccinated students, check their seroconversion, and correlate this with vaccination. Methods: One hundred and forty-three students' blood samples and their vaccination schedules were analyzed. Results: 65.7% were positive for anti-HBs; however, anti-HBs was absent in 34.3%. Only two samples were positive for anti-HBc IgG. Conclusions: More than 30% of students did not have minimum protective levels. Comparing HBV vaccination and anti-HBs reactivity, the majority of reactive individuals received their last dose within the past 16 years.

Perfil Vacinal E Sorológico Para Hepatite B De Acadêmicos De Enfermagem / Vaccination and Serological Profile for Hepatitis B of Nursing Students

“…No Brasil, a vacinação em adultos contra a hepatite B é disponibilizada na rede de atenção primária à saúde e deve ser realizada em três doses, em períodos de zero, um e seis meses de intervalo 14 . A detecção de anticorpos anti-HBs ≥ 10 mUI/mL após a terceira dose da vacina confirma a imunidade contra a doença 5 , contudo, aproximadamente 10% dos indivíduos vacinados não alcançam os títulos protetores de anticorpos 15,16 .…”