Evaluation of functional disability after Chikungunya infection

Panato, Cristiane Silvia; Figueredo, Eduardo; Bassi, Daniela; Felipe, Ilana Mírian Almeida; Firmo, Wellyson da Cunha Araújo; Rêgo, Adriana Sousa; Silva, Flor de Maria Araújo Mendonça

doi:10.1590/0037-8682-0112-2019

Cited by 11 publications

(3 citation statements)

References 14 publications

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“…Females outnumbered male participants in the diagnosis of chikungunya. Similar results have been described in other studies [ 28 – 30 ]. A combination of fever, arthralgia, and prostration was the most prevalent presentation in our cohort, which is consistent with the results described by Anwar et al [ 29 ].…”

Section: Discussionsupporting

confidence: 93%

Detection of Chikungunya virus in bodily fluids: The INOVACHIK cohort study

et al. 2022

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Background Chikungunya is a widely distributed, re-emerging tropical disease caused by the chikungunya virus (CHIKV). Little is known about the duration for which CHIK RNA are detectable in bodily fluids, especially genital secretions, and current evidence is based on small series or case reports. An understanding of viral dynamics across different body compartments can inform diagnostic testing algorithms and public health prevention interventions. Methodology A prospective cohort study was conducted to assess the presence and duration of detectable levels of CHIKV RNA in blood, urine, saliva, semen, and vaginal secretions. Men and women (≥ 18 years) with a positive reverse transcriptase-polymerase chain reaction (RT-PCR) test for CHIKV in the acute phase (1–14 days) of the disease were included. After enrollment, clinical data and samples were collected every 15 days over the first 2 months, and a final collection was performed 3 months after recruitment. The Kaplan–Meier interval-censoring method and the parametric Weibull model were fitted to estimate the median time of viral persistence until the lack of CHIKV RNA detection among all body fluids. Punctual estimates of the median time of CHIKV RNA persistence for each fluid were estimated using a 95% confidence interval (CI). Results From April to December 2019, 170 participants were screened. Of these, 152 (100 women) were enrolled in the study. The median and interquartile range (IQR) ages for men and women were 39.3 (IQR: 26.9, 50.7) and 43.5 (IQR: 33.8, 53.6) years, respectively. CHIKV RNA was detected in 80.3% (122/152) of serum samples, 23.0% (35/152) of urine samples, 30.3% (46/152) of saliva samples, 14.3% (6/42) of semen samples, and 20.2% (20/99) of vaginal secretion samples. The median time until the loss of CHIKV RNA detection was 19.6 days (95% CI, 17.5–21.7) in serum, 25.3 days (95% CI, 17.8–32.8) in urine, 23.1 days (95% CI, 17.9–28.4) in saliva, and 25.8 days (95% CI, 20.6–31.1) in vaginal secretion. The number of semen samples available was too small to make statistical estimates, but a last positive sample was obtained from a participant 56 days after the onset of symptoms. Conclusions CHIKV RNA could be detected in all bodily fluids studied, including genital secretions during the acute and convalescent phases and additional studies on viral infectivity in semen and vaginal secretions are warranted.

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Section: Discussionsupporting

confidence: 93%

Detection of Chikungunya virus in bodily fluids: The INOVACHIK cohort study

et al. 2022

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“…Os autores, a partir de uma amostra de 306 pessoas por um tempo de 12 meses, constaram que 30,6% apresentaram artralgia persistente e 27,5% severa (O'SULLIVAN et al, 2018). Panato et al (2019), a partir de pesquisa com 130 pessoas as quais foram também acompanhadas por 12 meses, verificaram 38% de acometimentos reumatológicos. Bouquillard et al (2017), a partir de investigação com 307 pessoas as quais foram acompanhadas por 32 meses, estimaram no grupo 83,1% com doenças reumáticas.…”

Section: Resultsunclassified

Prevalência de inflamações reumatológicas crônicas em pacientes acometidos por chikungunya

Sousa

Tomé

Valério

et al. 2021

CONJ

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O trabalho buscou estimar a prevalência de inflamações reumatológicas crônicas em pacientes acometidos por Chikungunya. Tratou-se de uma revisão sistemática da literatura com buscas na Literatura Latino-Americana e do Caribe em Ciências da Saúde, Medical Publications e Scientific Electronic Library Online. A pesquisa foi realizada em maio de 2020 e a estratégia de busca incluiu as combinações dos termos: “Chikungunya”, “rheumatism”, “post chikungunya” e “follow up”. A maioria dos estudos (80%) foi de coorte. Em relação ao local de realização, 30% foram realizados na Colômbia. A prevalência das inflamações reumatológicas crônicas pós-infecção pelo vírus da Chikungunya variou de 25,3% a 83,1%. Há uma alta prevalência de lesões reumatológicas crônicas em pacientes, que não possuíam nenhuma doença reumatológica crônica preexistente e que foram infectados pelo vírus chikungunya. Além disso, grande parte dos estudos foi em países latino-americanos, possivelmente devido o fato de serem países tropicais.

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“…Of note, most of the studies included for analysis contained data from patients who presented ocular alterations in the acute and post-acute phases of the disease, with only 2 out of the 25 studies [20,22] presenting data from chronic eye alterations such as reduced visual acuity, following CHIKV infection. Therefore, we were unable to establish how long each ocular alteration may last for following infection.…”

Section: Discussionmentioning

confidence: 99%

Ocular Manifestations of Chikungunya Infection: A Systematic Review

Silva¹,

Platner²,

Fonseca³

et al. 2022

Pathogens

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The Chikungunya virus (CHIKV) can cause long lasting symptoms and manifestations. However, there is little information on which ocular ones are most frequent following infection. We performed a systematic review (registered in the International Prospective Register of Systematic Reviews; no CRD42020171928) to establish the most frequent ocular manifestations of CHIKV infection and their associations with gender and age. Articles published until September 2020 were selected from PubMed, Scielo, Cochrane and Scopus databases. Only studies with CHIKV-infected patients and eye alterations were included. Reviews, descriptive studies, or those not investigating the human ocular manifestations of CHIKV, those with patients with other diseases and infections, abstracts and studies without relevant data were excluded. Twenty-five studies were selected for inclusion. Their risk of bias was evaluated by a modified Newcastle-Ottawa scale. The most frequent ocular symptoms of CHIKV infection included ocular pain, inflammation and reduced visual acuity, whilst conjunctivitis and optic neuritis were the most common manifestations of the disease. These occurred mostly in individuals of 42 ± 9.5 years of age and woman. The few available reports on CHIKV-induced eye manifestations highlight the need for further research in the field to gather more substantial evidence linking CHIKV infection, the eye and age/gender. Nonetheless, the data emphasizes that ocular alterations are meaningful occurrences of CHIKV infection which can substantially affect quality of life.

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Evaluation of functional disability after Chikungunya infection

Cited by 11 publications

References 14 publications

Detection of Chikungunya virus in bodily fluids: The INOVACHIK cohort study

Detection of Chikungunya virus in bodily fluids: The INOVACHIK cohort study

Prevalência de inflamações reumatológicas crônicas em pacientes acometidos por chikungunya

Ocular Manifestations of Chikungunya Infection: A Systematic Review

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