Epidemiological factors associated with Toxoplasma gondii infection in postpartum women treated in the public healthcare system of Goiânia, State of Goiás, Brazil

Avelar, Juliana Boaventura; Silva, Marcos Gontijo da; Rezende, Hanstter Hallison Alves; Storchilo, Heloísa Ribeiro; Amaral, Waldemar Naves do; Xavier, Isolina Rodrigues; Avelino, Mariza Martins; Castro, Ana Maria de

doi:10.1590/0037-8682-0112-2017

Cited by 22 publications

(22 citation statements)

References 28 publications

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“…The prevalence of T. gondii infection increases with age and the bivariate logistic regression analysis showed that there was a statistical association between the age groups and the positivity for IgG anti-T. gondii, with a higher probability of prior exposure for those aged 25 and over. These results were similar to the findings of most surveys that included not only pregnant women, postpartum and of reproductive age, but also those in the general population [32,33] and could be explained by the increase in exposure to sources of infection throughout life [34,35].…”

Section: Plos Onesupporting

confidence: 88%

Serological prevalence of toxoplasmosis in pregnant women in Luanda (Angola): Geospatial distribution and its association with socio-demographic and clinical-obstetric determinants

et al. 2020

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We report a study on toxoplasmosis in pregnant women in Luanda, Angola, determining the seroprevalence, geospatial distribution and its association with socio-economic features, dietary habits and hygiene and health conditions. Anti-Toxoplasma gondii IgG and IgM were quantified in serum samples of women attended at the Lucrecia Paim Maternity Hospital between May 2016 and August 2017. The IgG avidity test and qPCR assay were used for dating the primary infection. Data were collected by questionnaire after written consent, and spatial distribution was assessed through a Kernel Density Function. The potential risk factors associated with Toxoplasma infection were evaluated using bivariate and multivariate binomial logistic regression analysis. Anti-T. gondii antibodies were quantified in 878 pregnant women, and 346 (39.4%) samples were IgG positive, 2 (0.2%) positive for IgM and IgG, and 530 (60.4%) negative for both immunoglobulins. The longitudinal study showed that none of the seronegative women seroconverted during the survey. Regarding other infections, 226 (25.7%) were positive for hepatitis B, while 118 (13.4%) were HIV-positive. The seroprevalence of toxoplasmosis was similar in most municipalities: 43.8% in Cazenga (28 of 64); 42.5% in Viana (88 of 207); 42.3% in Cacuaco (22 of 52); and 41.1% in Luanda ((179 of 435). In contrast, the seroprevalence in municipality of Belas was lower (25.8%; 31 of 120) and bivariate and multivariate analysis has shown a lower risk for toxoplasmosis in this area (OR 0.479, CI: 0.305–0.737; OR 0.471, CI: 0.299–0.728). The multivariate analysis has shown a significant increased risk for toxoplasmosis in women in the last trimester of pregnancy (OR 1.457, CI: 1.011–2.102), suffering spontaneous abortion (OR 1.863, CI: 1.014–3.465) and having pets at home (OR 1.658, CI: 1.212–2.269). Also, women who tested positive for hepatitis B (OR 1.375, CI: 1.008–1.874) and HIV (OR 1.833, CI: 1.233–2.730) had a significant increased risk for T. gondii infection. In conclusion, our study showed that a large number of pregnant women are not immunized for toxoplasmosis and identified the risk factors for this infection in Luanda. It is crucial to establish the diagnosis of primary maternal infection as well as the diagnosis of congenital toxoplasmosis. Our results underlined the need for diagnostic and clinical follow-up of toxoplasmosis, HIV and hepatitis B during pregnancy.

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Section: Plos Onesupporting

confidence: 88%

Serological prevalence of toxoplasmosis in pregnant women in Luanda (Angola): Geospatial distribution and its association with socio-demographic and clinical-obstetric determinants

et al. 2020

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“…This suggests that factors affecting the risk of infection are more complex than a simple urban-rural division and may be confounded by other factors. This association was also found in other studies from Iran and Brazil 6,[11][12][13] .…”

Section: /6supporting

confidence: 88%

“…Through multivariate analysis, we found that the presence of cats had no association with the seroprevalence of toxoplasmosis in pregnancy. No association was also observed in other studies investigating the association between seroprevalence and the presence of household cats in Brazil 10,13 . However, some studies from Burkina Faso and Iran have shown an association 6,12 .…”

Section: /6mentioning

confidence: 56%

“…Threatened abortion during pregnancy was a risk factor. In previous studies, threatened abortion during the current pregnancy had not been assessed, but history of previous miscarriage was 6,13 . It is important to consider this factor and further investigate the possible associations between a threatened abortion during the current pregnancy and seropositivity for toxoplasmosis.…”

Section: /6mentioning

confidence: 99%

“…The seroprevalence is similar to values found in other regions-30% in Colombia 1 , 38% in Iran 6 , 43.5% in Aracaju, Brazil 10 , 31% in Sri Lanka 11 , and 30% in Burkina Faso 12 . However, in regions where toxoplasmosis is endemic, seropositivity for toxoplasmosis in pregnant women was even higher (50% in Sao Paulo, Brazil 7 and 89% in Goiania, Brazil 13 ). In our study, the prevalence of patients whose serology was compatible with an acute infection was 5.5%; this is similar to other studies 1,6,7 .…”

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confidence: 97%

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Seroprevalence of toxoplasmosis in pregnant women and its associated factors among hospital and community populations in Lambayeque, Peru

Silva-Díaz

Arriaga-Deza

Failoc-Rojas

et al. 2020

Rev. Soc. Bras. Med. Trop.

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Introduction: Toxoplasmosis is a zoonosis caused by Toxoplasma gondii. This study investigated the prevalence and factors associated with toxoplasmosis among pregnant women. Methods: We followed an analytical observational study. From July 2016 to June 2017, 218 pregnant women were selected. The infection was detected through serological dosage of anti-T.gondii Immunoglobulin(Ig) M and IgG antibodies. Results: The seroprevalence was 35.8%; the factors associated with infection were consumption of non-drinking water, residence in an urban area, and threatened abortion during the current pregnancy. Conclusions: The seroprevalence of toxoplasmosis among pregnant women is high. The risk factors are dependent on environmental determinants.

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Current Situation of Congenital Toxoplasmosis in Ecuador

et al. 2019

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Epidemiological factors associated with Toxoplasma gondii infection in postpartum women treated in the public healthcare system of Goiânia, State of Goiás, Brazil

Abstract: Our findings concur with the results of other studies conducted in Brazil and abroad, where variables such as low levels of schooling, and advanced age (≥ 30 years) are major risk factors for pregnant women to become infected with T. gondii.

Cited by 22 publications

References 28 publications

Serological prevalence of toxoplasmosis in pregnant women in Luanda (Angola): Geospatial distribution and its association with socio-demographic and clinical-obstetric determinants

Serological prevalence of toxoplasmosis in pregnant women in Luanda (Angola): Geospatial distribution and its association with socio-demographic and clinical-obstetric determinants

Seroprevalence of toxoplasmosis in pregnant women and its associated factors among hospital and community populations in Lambayeque, Peru

Current Situation of Congenital Toxoplasmosis in Ecuador

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