Candida arthritis in a patient diagnosed with spondyloarthritis

Çevik, Remzi; Tekin, Recep; Gem, Mehmet

doi:10.1590/0037-8682-0089-2016

Cited by 9 publications

(3 citation statements)

References 8 publications

(11 reference statements)

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“…Our study found seven cases with primary fungal knee septic arthritis, which is very rarely described in literature (Taxy and Kodros, 2005;Dewar and Sigler, 2010;Gamaletsou et al, 2012;Lee et al, 2012;Lu et al, 2012;Jeong et al, 2013;Miller et al, 2015;Cevik et al, 2016). It usually occurs as a result of accidental implantations of fungus during traumatic procedures, such as surgery, and is usually reported in patients with predisposing factors such as immunosuppression, malignancy, and drug abuse (Lee et al, 2012).…”

Section: Surgery Combined With Long-term Antifungal Treatment Achieve...mentioning

confidence: 53%

“…Common routes of infection include direct inoculation, contiguous spread, and hematogenous dissemination ( Miller et al., 2015 ). FOI resulting from fungemia, skin lesion, or trauma was rarely reported ( Taxy and Kodros, 2005 ; Dewar and Sigler, 2010 ; Lee et al., 2012 ; Lu et al., 2012 ; Jeong et al., 2013 ; Cevik et al., 2016 ), while FOIs secondary to orthopedic surgeries were more commonly seen in literature, especially in implant-related cases. Implant-related fungal infections, typically fungal periprosthetic joint infection (PJI) after hip/knee arthroplasty, was even more difficult to diagnose and treat for the reason of biofilm formation on the bioprosthetic surfaces ( Cobo et al., 2016 ).…”

Section: Introductionmentioning

confidence: 99%

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Metagenomic next-generation sequencing assists the diagnosis treatment of fungal osteoarticular infections

Zhang

Lin

Huang

et al. 2022

Front. Cell. Infect. Microbiol.

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BackgroundFungal osteoarticular infection (FOI) is not commonly seen in clinical practice but proposes a great challenge to orthopedic surgeons. In this study, we aimed to investigate the risk factors, the clinical features, and surgical outcomes of FOI in our institution. Specifically, we aimed to explore the role of metagenomic next-generation sequencing (mNGS) in the diagnosis and treatment of FOI.MethodsAll the patients who were diagnosed and managed with FOI in our institution from January 2007 to December 2020 were retrospectively reviewed, including primary fungal implant-related infection, primary fungal osteomyelitis or arthritis, and fungal infections secondary to bacterial osteomyelitis or implant-related bacterial infections. The potential risk factors and the clinical and surgical features were analyzed. The pathogen data were compared between culture and the mNGS test.ResultsA total of 25 patients were included, namely, 12 primary implant-related infections, 7 primary fungal osteomyelitis or arthritis, and 6 fungal infections secondary to bacterial osteomyelitis or implant-related bacterial infections. Most cases had undergone multiple surgeries or long-term antibiotic treatment. Diagnosis was mainly based on microbial culture and the mNGS test. Optimization of culture methods and the use of mNGS assisted the diagnosis. Specifically, mNGS was performed in 12 patients, 5 of whom were culture-negative. In the remaining seven cases, mNGS demonstrated the same results as culture. Management of FOI was complicated as most patients required multiple surgeries followed by long-term antifungal treatment. In selected cases, antifungal-impregnated cement spacer retention can be an optional choice. The overall success rate was 100% (25/25) for our cohort.ConclusionWe concluded that patients with comorbidities and a history of multiple surgeries or long-term antibiotics are under higher risk for FOI. Use of mNGS assists the diagnosis and treatment of FOI. Surgery combined with long-term antifungal treatment achieved satisfactory outcomes. In selected cases, antifungal-impregnated cement spacer retention can be an optional treatment choice.

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Section: Surgery Combined With Long-term Antifungal Treatment Achieve...mentioning

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Metagenomic next-generation sequencing assists the diagnosis treatment of fungal osteoarticular infections

Zhang

Lin

Huang

et al. 2022

Front. Cell. Infect. Microbiol.

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“…[42] 2016 1 Kadın/68 Dirsek C. parapsilosis Romatoid artrit CAS→ FLK İyileşme Çevik ve ark. [43] 2016 1…”

Section: Mi̇ka→ Flkunclassified

Osteoarticular Candida Infection: Case Reports and Literature Review

Aksoy¹,

Aydın²,

Ertuğrul³

et al. 2019

mjima

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Funguslara bağlı kemik eklem enfeksiyonları nadirdir. Kandida türlerine bağlı osteomiyelit de oldukça nadir görülen bir durumdur. Etken olarak en sık Candida albicans görülür, ancak son yıllarda non-albicans Candida'ların da osteomiyelitlerde sıklığının arttığı bildirilmektedir. Bu yazıda nonalbicans Candida osteomiyeliti olan üç olgu sunuldu. Osteoartiküler tutuluma bakıldığında olguların birinde lomber vertebra, birinde el, diğerinde ise ayak osteomiyeliti vardı. Olguların üçünde diabetes mellitus ve uzun süreli antibiyotik kullanımı ortak risk faktörleriydi. Vertebral osteomiyelit olan olguda ayrıca cerrahi girişim ve yabancı cisim varlığı diğer risk faktörleriydi. Olguların tanısında manyetik rezonans görüntüleme kullanıldı ve alınan derin doku kültüründe etken izole edildi. Tüm olgulara cerrahi debritman yapılarak altı hafta ile 24 hafta arasında değişen sürede antifungal tedavi verildi. Olgularda klinik ve radyolojik takiplerde enfeksiyon tekrarlamadı. Ayağında osteomiyeliti olan olgu akut serebrovasküler hastalık nedeni ile eksitus oldu. Çalışmamızda Nisan 2010-Haziran 2019 tarihleri arasında osteoartiküler Candida enfeksiyonu ile ilgili literatür taraması yapıldı ve 44 olgu derlendi. Çalışmamızda bu olguları sunmadaki amacımız, kandidaya bağlı osteoartiküler enfeksiyonlara dikkati çekmek ve etken tanımlanmasıyla hedefe yönelik tedavinin önemini vurgulamaktır. Anahtar Kelimeler: Spondilodiskit, flukonazol, kaspofungin, sistematik derleme, lipozomal amfoterisin b Fungal infections in the bones and joints are rare. Candida spp. osteomyelitis is also a very rare entity. The most common pathogen is Candida albicans, but an increase in the incidence of non-albicans Candida osteomyelitis has been reported in recent years. Herein, we present three patients with non-albicans Candida osteomyelitis. Osteoarticular involvement occurred in the lumbar vertebrae in one patient, in the hand in one patient, and the foot in the other patient. Diabetes mellitus and long-term antibiotic use were common risk factors in all three cases. In the patient with vertebral osteomyelitis, surgical intervention and foreign body were other risk factors. Magnetic resonance imaging was used in the diagnosis and the pathogens were isolated from deep tissue cultures. Surgical debridement was performed in all cases and antifungal treatment was given for 6-24 weeks. There was no reinfection or relapse during clinical and radiological follow-up. The patient with osteomyelitis of the foot died due to to acute cerebrovascular disease. In our study, the literature review for publications related to osteoarticular Candida infection was made between April 2010 and June 2019 and 44 cases are reviewed. Our aim in this study was to draw attention to Candida osteoarticular infections and to emphasize the importance of targeted treatment by defining the pathogen.

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