Lack of evidence for human infection with Xenotropic murine leukemia virus-related virus in the Brazilian Amazon basin

Abstract

Introduction:This study confi rmed the absence of natural infection with Xenotropic murine leukemia virus-related virus (XMRV) or XMRV-related disease in human populations of the Brazilian Amazon basin. We demonstrated that 803 individuals of both sexes, who were residents of Belem in the Brazilian State of Pará, were not infected with XMRV. Methods: Individuals were divided into 4 subgroups: healthy individuals, individuals infected with human immunodefi ciency virus, type 1 (HIV-1), individuals infected with human T-lymphotrophic virus, types 1 or 2 (HTLV-1/2), and individuals with prostate cancer. XMRV infection was investigated by nested PCR to detect the viral gag gene and by quantitative PCR to detect pol. Results: There was no amplifi cation of either gag or pol segments from XRMV in any of the samples examined. Conclusions: This study supports the conclusions of the studies that eventually led to the retraction of the original study reporting the association between XMRV and human diseases.

Is a Retrovirus (XMRV) Risk Factor for Prostate Cancer in Indian Population

“…However, there are several other reports shown to have high prevalence of XMRV in prostate cancer patients in different populations (Arnold et al, 2010;Schlaberg et al, 2009;Urisman et al, 2006). In contrast, few studies from different geographical regions have also reported almost no XMRV infection in PCa (Gomes et al, 2014;Sakuma et al, 2011). These discrepancies in the status of XMRV infection worldwide may be due to different geographical area, ethnicity and different lifestyle habits may affect the prevalence of XMRV infection in prostate cancer.…”