2018
DOI: 10.1016/j.ijsu.2018.02.050
|View full text |Cite
|
Sign up to set email alerts
|

Viral etiology of prostate cancer: Genetic alterations and immune response. A literature review

Abstract: Prostate cancer is one of the most common cancers in men. Recent estimates suggest that over a million men are diagnosed with the disease annually. Prostate cancer pathogenesis involves both heritable and environmental factors. The molecular events involved in the development or progression of prostate cancer are still unclear. Recent body of literature highlights the role of viral infections in initiation or progression of prostate cancer. In this regard, certain viruses have been reported to interact with ho… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
12
0

Year Published

2018
2018
2023
2023

Publication Types

Select...
7
3

Relationship

0
10

Authors

Journals

citations
Cited by 22 publications
(12 citation statements)
references
References 47 publications
0
12
0
Order By: Relevance
“…Chronic prostate inflammation (that could be induced by a viral infection) is thought to increase the risk of prostate cancer (436), and a link between prostate cancer, sexual activity and sexually-transmitted infection was reported in some studies (306). However, despite years of investigations on HPV (3,35,301,675,756,760), KSHV, EBV, BK virus, CMV (3, 301), and the "rumor" virus Xenotropic murine leukemia related virus (XMRV) (531) through serology testing or prostate tissue analysis by PCR, in situ hybridization or immunohistochemistry, there is no compelling evidence for a viral etiology of prostate cancer. Nevertheless, a few studies suggested that KSHV and HPV may represent a risk factor for prostate cancer aggressiveness (239,494,756).…”
Section: Prostate Cancermentioning
confidence: 99%
“…Chronic prostate inflammation (that could be induced by a viral infection) is thought to increase the risk of prostate cancer (436), and a link between prostate cancer, sexual activity and sexually-transmitted infection was reported in some studies (306). However, despite years of investigations on HPV (3,35,301,675,756,760), KSHV, EBV, BK virus, CMV (3, 301), and the "rumor" virus Xenotropic murine leukemia related virus (XMRV) (531) through serology testing or prostate tissue analysis by PCR, in situ hybridization or immunohistochemistry, there is no compelling evidence for a viral etiology of prostate cancer. Nevertheless, a few studies suggested that KSHV and HPV may represent a risk factor for prostate cancer aggressiveness (239,494,756).…”
Section: Prostate Cancermentioning
confidence: 99%
“…[ 3 , 4 ] Until now, the detailed mechanisms and exact etiology of PA remains unclear. [ 5 ] In addition, the prevention and treatment for PA is still complicated depending on the stage of disease and the choice of single patient. [ 6 ] Therefore, it is urgent to update the molecular mechanism of PA pathogenesis and explore new targeted therapies.…”
Section: Introductionmentioning
confidence: 99%
“…Heritable factors and environmental factors may cause prostate cancer together. Recent research focus on the role of viral infections in prostate cancer [57]. Cytosolic DNA sensing is associated to the secretion of cytokines [58].…”
Section: Discussionmentioning
confidence: 99%