Antimicrobial susceptibility of Neisseria gonorrhoeae isolates from patients attending a public referral center for sexually transmitted diseases in Belo Horizonte, State of Minas Gerais, Brazil

Costa, Ligia Maria Bedeschi; Pedroso, Ênio Roberto Pietra; Neto, Virgilio Vieira; Souza, Viviane Cata Preta; Teixeira, Maria Juliana Bastos

doi:10.1590/0037-8682-0009-2013

Cited by 13 publications

(15 citation statements)

References 17 publications

(22 reference statements)

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“…In this study all isolates were 100 % susceptible to ceftriaxone which was analogous to 100 % susceptibility reported in Nepal [ 26 ], India [ 27 ], Brazil [ 28 ], Tanzania [ 20 ] and Ethiopia [ 6 ]. Our finding was also comparable to 99 % susceptibility towards the same antibiotic documented in Bangladesh [ 22 ].…”

Section: Discussionsupporting

confidence: 80%

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Neisseria gonorrhoeae among suspects of sexually transmitted infection in Gambella hospital, Ethiopia: risk factors and drug resistance

et al. 2016

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BackgroundNeisseria gonorrhoeae is a bacterium responsible for one of the classic sexually transmitted infection (STI) gonorrhea. Antibiotic resistant strains are emerging at alarming rate. Multiple sexual partners, unsafe sex and substance use habits are the main host related risk factors for acquiring the infection. Thus, this study aimed at determining the magnitude, its determinants and antimicrobial resistance profile of N. gonorrhoeae in a place where there is risk related cultural practices and relatively high HIV prevalence.MethodsA cross-sectional study was conducted on 186 STI suspected patients seen in Gambella hospital from March to July 2015. Data on socio-demographic characteristics and associated risk factors was collected using pre-designed questionnaire. Urethral or endo-cervical swabs were collected aseptically by trained nurses. Then, samples were transported to laboratory and processed within 15 min following standard microbiological culture techniques. Antimicrobial susceptibility test was performed by using Kirby-Bauer disk diffusion method. Data entry, transforming and analysis was done using SPSS version 20.ResultsIn this study 11.3 % of the STI suspected patients were confirmed to have N. gonorrhoeae. The rate of infection in males was four times higher than in females accounting 16.0 and 5.0 % respectively (p = 0.049). It was also higher (18.9 %) in 20–24 years age group (p = 0.439). Alcohol intake (p = 0.013), less frequent condom use (p = 0.031), and multiple sex partners (p = 0.024) were associated with increased odds of infection. All N. gonorrhoeae isolates were susceptible to ceftriaxone and cefoxitin but all were resistant to penicillin and tetracycline. Alarmingly, 28.6 % of the isolates were resistant to ciprofloxacin.ConclusionsThe proportion of urogenital symptoms attributable to N. gonorrhoeae was high (11 %), with highest prevalence among males and young adults. Hence, prevention efforts should consider behavioral risk reduction. Ceftriaxone and cefoxitin can be considered as excellent first-line treatment options. However, alarming rate of resistance to ciprofloxacin challenges the current use of this antibiotic in the syndromic management package of gonococcal infections. Thus, laboratory based diagnosis and treatment system is need.

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Section: Discussionsupporting

confidence: 80%

“…These two antibiotics remain effective in the area because the drugs are newly introduced so that not used widely and frequently. However, 95.2 % susceptibility to spectinomycin obtained in this study was somehow lower compared to each 100 % susceptibility documented in Bangladesh [ 22 ] and Brazil [ 28 ].…”

Section: Discussioncontrasting

confidence: 77%

Neisseria gonorrhoeae among suspects of sexually transmitted infection in Gambella hospital, Ethiopia: risk factors and drug resistance

et al. 2016

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“…In addition, we also found high rate of resistance to tetracycline (51.8%). A similar rate of resistance to tetracycline has been observed in clinical isolates of N. gonorrhoeae in studies made in Brazil (Costa et al, 2013), Mozambique (Apalata et al, 2009), India, Pakistan and Bhutan (Sethi et al, 2013). No statistically significant associations were finally observed between the resistance of N. gonorrhoeae isolates and sex, age and region/country (p>0.05).…”

Section: Discussionsupporting

confidence: 74%

“…To our knowledge, this study is the first one in Spain that has explored the percentage of cases of chlamydiasis and region/country, sex and age profiles of individuals infected with C. trachomatis. As compared to other studies in Brazil by Costa et al (2013), the percentage of cases of gonorrhea in Madrid that we estimated was unique (5.5%). Our findings are supported by those of other studies conducted by Orellana et al (2009) showing about 7.4% of cases of gonorrhea in Pontones, Madrid.…”

Section: Discussioncontrasting

confidence: 65%

“…Our results are in agreement with previous data obtained in an earlier study made in Barcelona (Serra-Pladevall et al, 2013). On other hand, lower resistance rates have been observed in studies conducted in Pontones-Madrid (Orellana et al, 2009), Kenia (Lewis et al, 2011) and Brazil (Costa et al, 2013). In addition, we also found high rate of resistance to tetracycline (51.8%).…”

Section: Discussionsupporting

confidence: 53%

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Pathogens associated with sexually transmitted infections: distribution patterns of C. trachomatis, N. gonorrhoeae, M. hominis and U. urealyticum, antimicrobial resistance and molecular characterization of Neisseria gonorrhoeae isolates

Cane¹,

rnandez-Mora²,

Roblas³

2016

MJM

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Aims: The purpose of this study was to determine pathogens associated with sexually transmitted infections and the antimicrobial resistance among Neisseria gonorrhoeae isolates. Methodology and results: Urethral, endocervical and anal-rectal swabs were tested for Chlamydia trachomatis, N. gonorrhoeae, Mycoplasma hominis and Ureaplasma urealyticum. The molecular characterization of some N. gonorrhoeae isolates was made using NG-MAST. The total positive infection rate for C. trachomatis, N. gonorrhoeae and Mycoplasmas on the screened samples was 13% (541/4140), 5.5% (506/9232) and 5.5% (504/9232), respectively. One of the N. gonorrhoeae isolates (ST 3158) was cefixime-resistant (MIC ≥ 0.25 µ/mL). Men are at more risk of U. urealyticum infection (p< 0.05) while women are at more risk of M. hominis infection (p< 0.05). Conclusion, significance and impact of study: We identified the first N. gonorrhoeae isolate with reduced susceptibility to ceftriaxone in the area served by our center. Further studies are needed in order to elucidate the relation between sex and ureaplasmal and mycoplasmal infection. Our findings are useful to draw local and national strategies to control the emergence of new STs related with treatment failure.

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Antimicrobial resistance in Neisseria gonorrhoeae : history, molecular mechanisms and epidemiological aspects of an emerging global threat

Costa-Lourenço

Santos

Moreira

et al. 2017

Brazilian Journal of Microbiology

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Neisseria gonorrhoeae is the agent of gonorrhea, a sexually transmitted infection with an estimate from The World Health Organization of 78 million new cases in people aged 15–49 worldwide during 2012. If left untreated, complications may include pelvic inflammatory disease and infertility. Antimicrobial treatment is usually effective; however, resistance has emerged successively through various molecular mechanisms for all the regularly used therapeutic agents throughout decades. Detection of antimicrobial susceptibility is currently the most critical aspect for N. gonorrhoeae surveillance, however poorly structured health systems pose difficulties. In this review, we compiled data from worldwide reports regarding epidemiology and antimicrobial resistance in N. gonorrhoeae, and highlight the relevance of the implementation of surveillance networks to establish policies for gonorrhea treatment.

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Antimicrobial susceptibility of Neisseria gonorrhoeae isolates from patients attending a public referral center for sexually transmitted diseases in Belo Horizonte, State of Minas Gerais, Brazil

Cited by 13 publications

References 17 publications

Neisseria gonorrhoeae among suspects of sexually transmitted infection in Gambella hospital, Ethiopia: risk factors and drug resistance

Neisseria gonorrhoeae among suspects of sexually transmitted infection in Gambella hospital, Ethiopia: risk factors and drug resistance

Pathogens associated with sexually transmitted infections: distribution patterns of C. trachomatis, N. gonorrhoeae, M. hominis and U. urealyticum, antimicrobial resistance and molecular characterization of Neisseria gonorrhoeae isolates

Antimicrobial resistance in Neisseria gonorrhoeae : history, molecular mechanisms and epidemiological aspects of an emerging global threat

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