Persistent metabolic syndrome and risk of cardiovascular disease in children and adolescents

Farias, Camilla Ribeiro Lima de; Medeiros, Carla Campos Muniz; Souza, Diogo Rodrigues; Costa, Ivelise Fhrideraid Alves Furtado da; Simões, Mônica Oliveira da Silva; Carvalho, Danielle Franklin de

doi:10.1590/0034-7167-2016-0564

Cited by 10 publications

(7 citation statements)

References 23 publications

(31 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…An increase in serum TG level in a MetS patient might be due to resistance to insulin action or insulin deprivation, which was associated with increased lipolysis, intraabdominal fat, which is metabolically very active, releases free fatty acid (FFA) into the portal circulation and the liver converts FFA into triglycerides, which result in high serum TG level. 21,22 This finding was in line with studies reported in India, 33 Iran, 31 Brazil, 34 Malaysia, 35 and Central America; 36 however, this finding is lower than a study reported from Gondar, Ethiopia 56.6%, 37 Hawassa, Ethiopia 68.1%, 38 and Brazil 57.9%, 39 but higher than a report from Iran. 31 The discrepancy in the burden of dyslipidemia might be due to differing cut points in some studies and dietary differences of the study participants.…”

Section: Discussionsupporting

confidence: 81%

Predictors of Lipid Profile Abnormalities Among Patients with Metabolic Syndrome in Southwest Ethiopia: A Cross-Sectional Study

Haile¹,

Haile²,

Timerga³

2021

VHRM

View full text Add to dashboard Cite

Background: Lipid profile abnormalities are an integral part of metabolic syndrome (MetS) and major underlying causes of cardiovascular disease (CVD) and type-2 diabetes mellitus (T2DM). Lipid profile abnormalities in a patient with MetS are resulted due to the presence of central obesity and insulin resistance. In Ethiopia, the burden and predictors of lipid profile abnormalities in a patient with MetS are not well known. Thus, this study aimed to determine the prevalence of lipid profile abnormalities and predictors among patients with MetS in southwest Ethiopia. Methods and Materials: A cross-sectional study was conducted among 381 patients with MetS from September to December 2019 with a response rate of 100%. A structured questionnaire was used to collect data on socio-demographic and behavioral factors. Waist circumference, height, weight, and blood pressures were measured. The venous blood sample was collected for glucose and lipid profile determination. Data were entered and analyzed by using SPSS version 21. Binary logistic regression and Pearson's correlation analyses were performed. A p-value was set at a <0.05 for statistical significance. Results: In this study, about 58% of participants were at least one or more lipid profile abnormalities with the 95% CI (52.8-62.7). About 67.2%, 44.6%,18.4%, and 14.2% of study participants were low HDL, high TG, LDL, and TC, respectively. Central obesity (adjusted odds ratio (AOR): 1.89, 95% CI: 1.14-3.14), increasing age (AOR: 2.08, 95% CI: 1.27-3.4), higher BMI (AOR: 2.06, 95% CI: 1.23-3.4), being hypertensive (AOR: 3.48, 95% CI: 2.12-5.7) and increasing blood glucose level (AOR: 2.34, 95% CI: 1.36-4.03) were independent predictors of lipid profile abnormalities (dyslipidemia). Conclusion:In this study area, a high (58%) prevalence of dyslipidemia was observed in study participants, and increasing age, higher BMI, central obesity, hypertension, and high blood glucose level were identified as independent predictors of dyslipidemia among patients with MetS. Prevention and control of dyslipidemia and its predictors among patients with MetS were recommended.

show abstract

Section: Discussionsupporting

confidence: 81%

Predictors of Lipid Profile Abnormalities Among Patients with Metabolic Syndrome in Southwest Ethiopia: A Cross-Sectional Study

Haile¹,

Haile²,

Timerga³

2021

VHRM

View full text Add to dashboard Cite

show abstract

“…Though the most common combination of MS components does not differ by gender, some sex-based differences and an increased number of MS components at early and late/post-puberty were detected. MS is defined by a constellation of physiological, biochemical, clinical and metabolic factors that directly increase the risk of atherosclerosis, type 2 diabetes mellitus (T2DM), and all-cause mortality [1][2][3][4][5][6].…”

Section: Discussionmentioning

confidence: 99%

“…Metabolic syndrome (MS) is defined as a cluster of several metabolic factors including obesity, abnormalities in glucose metabolism, hypertension and dyslipidemia, which increase the risk of diabetes mellitus and cardiovascular disease [1,2]. The development of metabolic complication in the pediatric age is directly linked to both excessive weight gain and early onset of obesity [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Gender-based differences in the clustering of metabolic syndrome factors in children and adolescents

Calcaterra

Larizza

Silvestri

et al. 2020

Journal of Pediatric Endocrinology and Metabolism

View full text Add to dashboard Cite

BackgroundWe depicted gender-differences in metabolic syndrome (MS) clustering before and after puberty in pediatrics, in order to develop gender specific preventive strategies for childhood obesity.MethodsWe considered 1079 children and adolescents (529 females and 550 males; mean age 11.5 ± 2.8 year). According to body mass index (BMI) percentiles the subjects were classified as normal weight BMI <75th, overweight BMI 75–95th and with obesity BMI >95th. MS was diagnosed when three of the following criteria for age and sex percentiles were met: BMI >95th, triglycerides (TGs) level >95th, high-density lipoprotein-cholesterol (HDL-c) level <5th, blood pressure (blood pressure) >95th percentile, fasting blood glucose (FBG) >100 mg/dL and/or homeostatic model assessment- insulin resistance (HOMA-IR) >97.5th percentile.ResultsThe prevalence of dismetabolic factors was similar in both genders, except for pathological BP, which was higher in males (p = 0.02). MS was detected only in patients with obesity, with a higher prevalence in pubertal than late/post-pubertal subjects (p < 0.001), without any significant difference between gender. In pre-puberty, the most common MS combination was obesity (HBMI) + hypertension (HBP) + hyperglycemia/insulin resistance (HGLY/IR) followed by HBMI + low HDL-levels (LHDL) + HGLY/IR versus HBMI + HBP + HGLY/IR followed by HBMI + HBP + LHDL, respectively, in females and males. In the early and late/post-pubertal periods, the most prevalent combination remained similar to pre-puberty, additionally in both sexes other combinations, such as HBMI + HTG + HBP + HGLY/IR, HBMI + HBP + LHDL + HGLY/IR, HBMI + HTG + LHDL + HGLY/IR and HBMI + HTG + LHDL + HBP + HGLY/IR were also detected, differently distributed in males and females.ConclusionsWe confirm that MS is an important consequence related to obesity, particularly in the post-puberty stage. Some gender-based differences should be considered early in order to identify specific preventive and treatment strategies.

show abstract

“…Neste caso, a paciente é encaminhada à outra unidade, o que se torna inviável para ela, considerada sua rotina pessoal e/ou profissional, além da insegurança de ir à um local novo, com equipe nova, para receber os cuidados numa área íntima. Destaca-se que a paciente que reage desta forma, na maioria das vezes, não recebeu uma orientação adequada e nem acolhimento foi feito da forma correta (CARVALHO et al, 2018;RAMOS et al, 2016).…”

Section: Discussionunclassified

Áreas Prioritárias Para Controle Da Hanseníase No Município De Jaboatão Dos Guararapes, Pernambuco, Brasil, 2017

Carneiro¹,

Francisco²,

Oliveira³

et al. 2020

Condições Teórico-Práticas Das Ciências Da Saúde No Brasil

View full text Add to dashboard Cite

Persistent metabolic syndrome and risk of cardiovascular disease in children and adolescents

Abstract: persistent MetS was associated with obesity, HDL-c and LDL-c, but not with the PDAY score.

Cited by 10 publications

References 23 publications

Predictors of Lipid Profile Abnormalities Among Patients with Metabolic Syndrome in Southwest Ethiopia: A Cross-Sectional Study

Predictors of Lipid Profile Abnormalities Among Patients with Metabolic Syndrome in Southwest Ethiopia: A Cross-Sectional Study

Gender-based differences in the clustering of metabolic syndrome factors in children and adolescents

Áreas Prioritárias Para Controle Da Hanseníase No Município De Jaboatão Dos Guararapes, Pernambuco, Brasil, 2017

Contact Info

Product

Resources

About