Enriched environment alleviates post-stroke cognitive impairment through enhancing α7-nAChR expression in rats

Yuan, Mei; Zhang, Xinxin; Fu, Xiao-Cui; Bi, Xia

doi:10.1590/0004-282x20200081

Cited by 10 publications

(3 citation statements)

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“…Interestingly, the incremental expression of synapse-associated proteins on the contralateral side of injury has a higher correlation with cognitive function compared with the ipsilateral side (Wang et al, 2019 ). In addition to the cholinergic circuit (Wang et al, 2016 ; Yuan et al, 2020 ), the upregulation of GABAergic and glutamatergic systems under the effect of EE in the contralateral hippocampus is also committed to the remission of PSCI (Wang et al, 2020 ), which suggests that EE recovery of PSCI is no longer limited to the damaged hemisphere at least in terms of synaptic plasticity and neurotransmitter system.…”

Section: The Effects Of Ee On Cns Disordersmentioning

confidence: 99%

The role of enriched environment in neural development and repair

Yuan

Guo

Shen

et al. 2022

Front. Cell. Neurosci.

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In addition to genetic information, environmental factors play an important role in the structure and function of nervous system and the occurrence and development of some nervous system diseases. Enriched environment (EE) can not only promote normal neural development through enhancing neuroplasticity but also play a nerve repair role in restoring functional activities during CNS injury by morphological and cellular and molecular adaptations in the brain. Different stages of development after birth respond to the environment to varying degrees. Therefore, we systematically review the pro-developmental and anti-stress value of EE during pregnancy, pre-weaning, and “adolescence” and analyze the difference in the effects of EE and its sub-components, especially with physical exercise. In our exploration of potential mechanisms that promote neurodevelopment, we have found that not all sub-components exert maximum value throughout the developmental phase, such as animals that do not respond to physical activity before weaning, and that EE is not superior to its sub-components in all respects. EE affects the developing and adult brain, resulting in some neuroplastic changes in the microscopic and macroscopic anatomy, finally contributing to enhanced learning and memory capacity. These positive promoting influences are particularly prominent regarding neural repair after neurobiological disorders. Taking cerebral ischemia as an example, we analyzed the molecular mediators of EE promoting repair from various dimensions. We found that EE does not always lead to positive effects on nerve repair, such as infarct size. In view of the classic issues such as standardization and relativity of EE have been thoroughly discussed, we finally focus on analyzing the essentiality of the time window of EE action and clinical translation in order to devote to the future research direction of EE and rapid and reasonable clinical application.

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Section: The Effects Of Ee On Cns Disordersmentioning

confidence: 99%

The role of enriched environment in neural development and repair

Yuan

Guo

Shen

et al. 2022

Front. Cell. Neurosci.

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“…Также в патогенезе постинсультных когнитивных и ноцицептивных нарушений показана роль холинергической синаптической передачи [10]. В эксперименте активация холинергической передачи подавляла процесс нейровоспаления и приводила к улучшению когнитивных функций [11].…”

Section: патофизиология отсроченных стадий ишемического поврежденияunclassified

Clinical and pathophysiological foundations and advanced developments in the rehabilitation of patients after ischemic stroke

Демьяновская

Васильев²

2021

Лечащий Врач

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При инфаркте мозга окклюзия церебральной артерии приводит к очаговой ишемии. Ишемический очаг представлен центральной зоной некроза, которая окружена областью так называемой ишемической полутени, нейроны которой потенциально жизнеспособны, однако кровоснабжение данной зоны длительно сохраняется на уровне ниже функциональных пороговых значений. Реабилитационные мероприятия играют важнейшую роль в улучшении качества жизни пациентов, перенесших церебральную мозговую катастрофу, а также их родственников и окружающих. Знание организационных аспектов, самых современных методик постинсультной реабилитации, а также понимание патогенеза нейронального повреждения и восстановления позволяют оптимизировать работу с такими пациентами. Накопленные на сегодняшний день данные свидетельствуют о том, что при правильно подобранном своевременном лечении восстановление утраченных функций после инсульта не только желательно, но и в значительной степени возможно. Условием успешной реабилитации является применение всех доступных методов немедикаментозного воздействия и лекарственной терапии. In cerebral infarction, occlusion of the cerebral artery leads to focal ischemia. The ischemic focus is represented by the central zone of necrosis, which is surrounded by an area of the so-called ischemic penumbra, the neurons of which are potentially viable, but the blood supply to this zone remains for a long time at a level below the functional threshold values. Rehabilitation plays a crucial role in improving quality of life in patients after acutevascular brain disorder, as well as their relatives and others. Understandingof legal basis, most modern methods of post-stroke rehabilitation, as well as an understanding of the pathogenesis of neuronal damage and recovery allow to optimize work with these patients. The data accumulated to date indicate that with properly selected timely treatment, the restoration of lost functions after a stroke is not only desirable, but also to a large extent possible. A condition for successful rehabilitation is the use of all available methods of non-drug exposure and drug therapy.

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“…Furthermore, a growing number of healthcare institutions have used acupuncture clinically and have shown that acupuncture can be a prospective therapeutic measure to enhance cognitive function in patients with PSCI ( 20 , 21 ). Meanwhile, animal models of PSCI have been used to explore the potential mechanisms of acupuncture treatment to achieve maximum benefit ( 22 , 23 ).…”

Section: Introductionmentioning

confidence: 99%

Acupuncture treatment vs. cognitive rehabilitation for post-stroke cognitive impairment: A systematic review and meta-analysis of randomized controlled trials

et al. 2023

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BackgroundCognitive impairment is one of the common sequelae after stroke, which not only hinders the recovery of patients but also increases the financial burden on families. In the absence of effective therapeutic measures, acupuncture treatment has been widely used in China to treat post-stroke cognitive impairment (PSCI), but the specific efficacy is unclear. Therefore, this review aimed to evaluate the true efficacy of acupuncture treatment in patients with PSCI.MethodsWe searched eight databases [PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials, China Biomedical Literature Database (CBM), China Science and Technology Journal (VIP) database, the China National Knowledge Infrastructure (CNKI) database, and Wan fang database] from the inception to May 2022 for randomized controlled trials (RCTs) related to acupuncture treatment combined with cognitive rehabilitation (CR) for PSCI. Two investigators independently used a pre-designed form to extract valid data from eligible RCTs. The risk of bias was assessed through tools provided by the Cochrane Collaboration. The meta-analysis was implemented through Rev Man software (version 5.4). The strength of the evidence obtained was evaluated using GRADE profiler software. Adverse events (AEs) were collected by reading the full text and used to evaluate the safety of acupuncture treatment.ResultsThirty-eight studies involving a total of 2,971 participants were included in this meta-analysis. Overall, the RCTs included in this meta-analysis were poor in methodological quality. The combined results showed that acupuncture treatment combined with CR showed significant superiority compared to CR alone in terms of improving cognitive function [Mean Difference (MD) = 3.94, 95% confidence intervals (CI): 3.16–4.72, P < 0.00001 (MMSE); MD = 3.30, 95%CI: 2.53–4.07, P < 0.00001 (MoCA); MD = 9.53, 95%CI: 5.61–13.45, P < 0.00001 (LOTCA)]. Furthermore, the combination of acupuncture treatment and CR significantly improved patients' self-care ability compared to CR alone [MD = 8.66, 95%CI: 5.85–11.47, P < 0.00001 (MBI); MD = 5.24, 95%CI: 3.90–6.57, P < 0.00001 (FIM)]. Meanwhile, subgroup analysis showed that MMSE scores were not sufficiently improved in the comparison of electro-acupuncture combined with CR versus CR alone (MD = 4.07, 95%CI: −0.45–8.60, P = 0.08). However, we also observed that electro-acupuncture combined with CR was superior to the use of CR alone in improving MoCA and MBI scores in patients with PSCI [MD = 2.17, 95%CI: 0.65–3.70, P = 0.005 (MoCA); MD = 1.74, 95%CI: 0.13–3.35, P = 0.03 (MBI)]. There was no significant difference in the occurrence of adverse events (AE) between acupuncture treatment combined with CR and CR alone (P > 0.05). The certainty of the evidence was rated low level because of flaws in the study design and considerable heterogeneity among the included studies.ConclusionThis review found that acupuncture treatment combined with CR may have a positive effect on improving cognitive function and self-care ability in PSCI patients. However, our findings should be treated with caution owing to the existence of methodological quality issues. High-quality studies are urgently required to validate our results in the future.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022338905, identifier: CRD42022338905.

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Enriched environment alleviates post-stroke cognitive impairment through enhancing α7-nAChR expression in rats

Cited by 10 publications

References 34 publications

The role of enriched environment in neural development and repair

The role of enriched environment in neural development and repair

Clinical and pathophysiological foundations and advanced developments in the rehabilitation of patients after ischemic stroke

Acupuncture treatment vs. cognitive rehabilitation for post-stroke cognitive impairment: A systematic review and meta-analysis of randomized controlled trials

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