The effect of vitamin D on cognitive functions in young female patients: a prospective controlled study using the Montreal Cognitive Assessment

Balbaloğlu, Özlem; Tanık, Nermin

doi:10.1590/0004-282x20180159

Cited by 6 publications

(5 citation statements)

References 32 publications

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“… 10 During pregnancy, women are also prone to vitamin D deficiency; this vitamin may be associated with cognitive functioning in young women. 11 Pregnancy complications, such as gestational hypertension, may increase the risk of long-term neurovascular abnormalities; this may also increase the risk of cognitive decline in women with this history. 12 , 13 Gestational diabetes mellitus-induced insulin resistance and glucose metabolism disorders may lead to cognitive function decline in women, 14 , 15 and postpartum depression is also considered to be related to cognitive impairment.…”

Section: Discussionmentioning

confidence: 99%

Investigation Regarding Early Cognitive Function of Women in the Postpartum Period and the Analysis of Influencing Factors

Qiu

Wen

Liu

et al. 2021

RMHP

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Objective The present study aims to assess the cognitive function of healthy full-term puerperae and compare it with the cognitive function of healthy non-pregnant women in order to analyze possible influencing factors. Methods The study subjects were divided into two groups: the maternal (case) group (n = 80) and the control group (n = 30). A total of 50 healthy single-birth full-term primiparous women and 30 women undergoing a second pregnancy were assigned to the maternal group, while 30 non-pregnant women matched by general data were assigned to the control group. Subject cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) (Beijing version) and the Birmingham Cognitive Screen (BCoS) (Mandarin version); related influencing factors were analyzed. Results In the maternal group, the results showed a MoCA score of 26.52 ± 2.13 points and a cognitive impairment incidence of 26% in primiparous women, along with a MoCA score of 25.83 ± 2.49 points and a cognitive impairment incidence of 36.7% in women undergoing a second pregnancy. All scores were lower in the maternal group than in the control group, which had a MoCA score of 27.47 ± 1.28 points and cognitive impairment incidence of 6.7% (p < 0.05). The differences in MoCA score and cognitive impairment incidence between the primiparous sub-group and the second pregnancy sub-group were not statistically significant (p > 0.05). The visual space and executive function MoCA scale scores were lower in the maternal group than in the control group (p < 0.01). Furthermore, the scores were lower in the maternal group than in the control group in the following BCoS items: instant story recall, total apple deletion number, auditory attention, rule conversion, and gesture imitation (p < 0.05). Conclusion Women in the postpartum period may develop cognitive dysfunction; however, the difference in cognitive impairment incidence between the primiparous sub-group and the second pregnancy sub-group in this study was not statistically significant. The educational level, labor analgesia, and total labor time (min) were found to be influencing factors in the postpartum cognitive function decline (p < 0.05).

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Section: Discussionmentioning

confidence: 99%

Investigation Regarding Early Cognitive Function of Women in the Postpartum Period and the Analysis of Influencing Factors

Qiu

Wen

Liu

et al. 2021

RMHP

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“…Many previous studies have revealed the association between vitamins and dementia (Travica et al, 2017;O'Leary et al, 2012;Balbaloglu and Tanik, 2019;Gibson et al, 2016;Hughes et al, 2017). However, there have been few studies that have examined differences in the sex with regard to the relationship between the vitamin level and dementia risk.…”

Section: Discussionmentioning

confidence: 99%

“…Many previous studies have investigated the relationship between vitamins and dementia (O'Leary et al, 2012;Gibson et al, 2016;Hughes et al, 2017;Travica et al, 2017;Balbaloglu and Tanik, 2019). However, the relationship between the vitamin B level and cognitive decline has yet to be fully assessed, especially with regard to differences associated with the sex.…”

Section: Introductionmentioning

confidence: 99%

Sex Differences in the Relationship of Serum Vitamin B1 and B12 to Dementia Among Memory Clinic Outpatients in Japan

Miki

Kinno

Ochiai

et al. 2021

Front. Aging Neurosci.

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Dementia and cognitive impairment are considered to be one of the biggest social and medical problems. While there is a definite relationship between vitamin B and cognitive decline, this has yet to be fully assessed with regard to sex differences. Thus, the present study investigated the relationship of vitamin B1 or vitamin B12 with dementia in accordance with the sex in 188 patients who visited the Memory Clinic at Showa University Hospital in Japan from March 2016 to March 2019. Cognitive function was tested by the Japanese version of the Mini-Mental State Examination (MMSE) and Hasegawa Dementia Scale-Revised (HDS-R). Blood tests were performed to measure the vitamin levels. Logistic regression analysis was used to calculate the odds ratio (OR) for dementia and the 95% confidence interval (CI). Compared to the highest vitamin group (third tertile), the lowest vitamin group (first tertile) exhibited a significantly increased OR for dementia defined by MMSE for vitamin B1 (OR:3.73, 95% CI:1.52–9.16) and vitamin B12 (2.97, 1.22–7.28) among women. In contrast, vitamin levels were not significantly associated with dementia determined by MMSE in men. These findings were similar even when dementia was defined by HDS-R. The present study suggests that vitamin B1 plays a role in preventing development of dementia in women. Future longitudinal studies will need to be undertaken in order to examine whether decreasing vitamin levels occur before or after cognitive impairment, and whether maintaining a higher vitamin level can prevent a worsening of cognitive function and the development of dementia.

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“…To investigate the results of vitamin D supplementation on cognitive function, studies have been carried out with healthy elderly people or with patients suffering from cognitive impairment or dementia, mainly AD. Since the effects in both groups could be different and this difference would be of utmost importance, we analyzed separately the studies conducted with each of these two groups (Table 2) [41][42][43][44][45][46][47][48][49][50][51][52][53][54][55]. N=273 (N=136,800 IU D3; N=137, 2,000 D3).…”

Section: Cognitive Function: What Do Recent Clinical Trials Indicatementioning

confidence: 99%

"Vitamin D and Cognitive Function: Descriptive Review of the Scientific Evidence"

Javier¹

2022

BJSTR

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Introduction: Considerable amounts of vitamin D are found in the brain and the vitamin D receptor is widely distributed throughout various brain regions. The effects of vitamin D on the regulation of genes involved in neuroprotection and neurotropism or neuronal regeneration have been described. There is a high prevalence of vitamin D deficiency or insufficiency among the elderly. The aim of this article is to review the relationship between vitamin D and cognition. We have attempted to answer three questions: Is there a physiological rationale that allows us to conclude that vitamin D has cognitively relevant effects? Is hypovitaminosis D associated with cognitive impairment? Does vitamin D supplementation have any effect on cognitive impairment or dementia? Development: A descriptive review has been conducted on the research that we have considered to be the most relevant published in the last decade: cross-sectional, prospective, and retrospective studies, and randomized placebo-controlled trials have been included. Conclusions:Preclinical studies show wide proof of concept that vitamin D may play a relevant role in cognitive functions. There is no consensus on the association of hypovitaminosis D and cognitive impairment, although most studies have found such an association. There is also no conclusive scientific evidence on beneficial effects of vitamin D supplementation on cognitive impairment, although the positive evidence available -mainly with cholecalciferol or vitamin D3 as preferred vitamin D form-is leading many authors and some clinicians to recommend it in usual practice. on vitamin D supplementation in this context and points out

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The effect of vitamin D on cognitive functions in young female patients: a prospective controlled study using the Montreal Cognitive Assessment

Cited by 6 publications

References 32 publications

Investigation Regarding Early Cognitive Function of Women in the Postpartum Period and the Analysis of Influencing Factors

Investigation Regarding Early Cognitive Function of Women in the Postpartum Period and the Analysis of Influencing Factors

Sex Differences in the Relationship of Serum Vitamin B1 and B12 to Dementia Among Memory Clinic Outpatients in Japan

"Vitamin D and Cognitive Function: Descriptive Review of the Scientific Evidence"

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