Basal cortisol levels and the relationship with clinical symptoms in multiple sclerosis: a systematic review

Pereira, Gabriela Magalhães; Soares, Nayron Medeiros; Souza, Andreo Rysdyk de; Becker, Jéfferson; Finkelsztejn, Alessandro; Almeida, Rosa M. M. de

doi:10.1590/0004-282x20180091

Cited by 17 publications

(11 citation statements)

References 64 publications

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“…Besides representing long-term exposure to stress in humans, hair cortisol concentration could denote balance with blood cortisol levels (Sauvé et al 2007). However, little is known about hair cortisol samples when investigating cortisol levels in MS (Pereira et al 2018;Scheffer et al 2019). Nevertheless, evidence has indicated a change in cortisol levels in other biological analysis from individuals with MS, such as saliva, blood, cerebrospinal fluid (CSF), and urine (Akcali et al 2017;Powell et al 2015;Melief et al 2013;Baranowska-Bik et al 2015;Ysrraelit et al 2008).…”

Section: Discussionmentioning

confidence: 99%

Hair cortisol concentration, cognitive, behavioral, and motor impairment in multiple sclerosis

et al. 2019

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Multiple sclerosis (MS) is an autoimmune neurodegenerative disease that is characterized by the demyelinated inflammatory processes that occur within the central nervous system. Hypothalamus-pituitary-adrenal axis (HPA axis) dysfunctions have been associated with the triggering or increase in MS symptoms. We thus aimed at evaluating motor and behavioral functions, planning skills, processing speed, and their relationship with stress through measuring hair cortisol concentration from patients with MS. The sample was composed of 40 volunteers that were clinically diagnosed with MS, along with 33 healthy adults. Evaluations included: Clinical Evaluation Form, Mini-Mental State Exam, Hamilton Depression Rating Scale, Multiple Sclerosis Functional Composite Measure, Expanded Disability Status Scale, Berg Balance Scale, Perceived Stress Scale, Zoo Map task, and a hair sample to analyze cortisol levels in the last 30 days. MS patients showed highly elevated hair cortisol levels in comparison to the control group (p = 0.048). All groups presented some degree of depressive and anxiety symptoms, aside from considerable perceived stress levels. The MS group presented deficits in gait, balance, manual skills and processing speed, and this was particularly so in individuals with moderate impairments when compared to control group (p < 0.001). Individuals with MS spent less time planning on ZooMap1 (p = 0.024) and made more mistakes (p < 0.001). No correlation was found between hair cortisol and the symptoms we assessed. However, depressive symptoms and anxiety were related to perceived stress, and higher hair cortisol suggests a change in levels in the HPA axis in MS. Nevertheless, future studies will be necessary to further understand how basal hair cortisol is related to MS symptoms.

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Section: Discussionmentioning

confidence: 99%

Hair cortisol concentration, cognitive, behavioral, and motor impairment in multiple sclerosis

et al. 2019

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“…Selain itu, sebagai dampak dari proses relaksasi, fungsi kerja hormon menjadi optimal. Fungsi kelenjar hipofisis sebagai penghasil hormon adeno-kortikotropin menekan kelenjar adrenal untuk mengatur ekskresi adrenalin dan kortisol dalam batas normal (Kandhalu, 2013;Pereira et al, 2018). Kondisi seperti ini akan membantu menurunkan stress biologis dan psikologis pada pasien kanker.…”

Section: Pendahuluanunclassified

Yoga Meningkatkan Kualitas Hidup Pada Pasien Kanker: Literature Review

Setiawan¹,

Khaerunnisa²,

Ariyanto³

et al. 2021

JHNS

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Cancer is a chronic disease that reduces the quality of life of the sufferer. High stressors and low coping due to disease prognosis, therapy management, and minimal social support, have an impact on poor psychological conditions. Therefore, we need complementary therapies such as yoga that is easy, cheap, and can be done independently. Yoga practice increases oxygen supply and relaxes muscles and joints which can increase hormonal work which is beneficial for the body physically and psychologically for cancer patients. Objective: This study aims to explain the effectiveness of yoga on increasing QoL (Quality of Life) in cancer patients. Research data were identified from 5 journal databases including PubMed, JSTOR (Journal Storage), Wiley Online Library, Sage Journal, and Taylor & Francis Online using the PIOS (Participant, Intervention, Outcomes and Study Design) method and MeSH term on advanced search engines. Articles that become research data are articles published in 2006-2020 in the English version, open access, and in full text in the original research article form. A total of 3050 articles were found, a screening process was carried out using the Prisma Protocol to eliminate articles that did not meet the criteria. This literature review study found 16 articles that prove that the use of yoga interventions can improve the quality of life of cancer patients. Cancer patients are advised to do self-care in the form of Yoga to improve their quality of life. Advanced research will need to compare the feasibility between yoga and different intervention.

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“…Cortisol is affected by the hyperactivity of the HPA axis in PwMS, another endogenous product of glucocorticoids that acts as an immunosuppressant and is involved in glucose metabolism and inflammatory and immunological reactions [ 14 , 15 ]. Moreover, cortisol has been introduced as a biomarker of the severity of mental disorders [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Tele-Pilates and Tele-Yoga on Biochemicals, Physical, and Psychological Parameters of Females with Multiple Sclerosis

Najafi

Hadizadeh

Cheong

et al. 2023

JCM

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Background: People with multiple sclerosis (PwMS) suffer from some comorbidities, including physical and psychiatric disorders, low quality of life (QoL), hormonal dysregulation, and hypothalamic-pituitary-adrenal axis dysfunction. The current study aimed to investigate the effects of eight weeks of tele-yoga and tele-Pilates on the serum levels of prolactin and cortisol and selected physical and psychological factors. Methods: Forty-five females with relapsing remitting multiple sclerosis, based on age (18–65), expanded disability status scale (0–5.5), and body mass index (20–32), were randomly assigned to tele-Pilates, tele-yoga, or control groups (n = 15). Serum blood samples and validated questionnaires were collected before and after interventions. Results: Following online interventions, there was a significant increase in the serum levels of prolactin (p = 0.004) and a significant decrease in cortisol (p = 0.04) in the time × group interaction factors. In addition, significant improvements were observed in depression (p = 0.001), physical activity levels (p < 0.001), QoL (p ≤ 0.001), and the speed of walking (p < 0.001). Conclusion: Our findings suggest that tele-yoga and tele-Pilates training could be introduced as patient-friendly, non-pharmacological, add-on therapeutic methods for increasing prolactin and decreasing cortisol serum levels and achieving clinically relevant improvements in depression, walking speed, physical activity level, and QoL in female MS patients.

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Basal cortisol levels and the relationship with clinical symptoms in multiple sclerosis: a systematic review

Cited by 17 publications

References 64 publications

Hair cortisol concentration, cognitive, behavioral, and motor impairment in multiple sclerosis

Hair cortisol concentration, cognitive, behavioral, and motor impairment in multiple sclerosis

Yoga Meningkatkan Kualitas Hidup Pada Pasien Kanker: Literature Review

Effects of Tele-Pilates and Tele-Yoga on Biochemicals, Physical, and Psychological Parameters of Females with Multiple Sclerosis

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