Wilson's disease: the 60th anniversary of Walshe's article on treatment with penicillamine

Teive, Hélio Afonso Ghizoni; Barbosa, Egberto Reis; Lees, Andrew

doi:10.1590/0004-282x20160166

Cited by 4 publications

(1 citation statement)

References 10 publications

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“…Its main mechanism of action is by the inhibition of HO activity (Juckett et al, 1998 ). Still there are risks of fatalities associated with this drug, along with the onset of aplastic anemia, thrombocytopenia, myasthenia gravis and Goodpasture syndrome (Louie et al, 1986 ; Peces et al, 1987 ; Fishel et al, 1989 ; Kaufman et al, 1996 ; Narayanan and Behari, 1999 ; Teive et al, 2017 ).…”

Section: Ethnopharmacological Approaches For Management Of Jaundice: mentioning

confidence: 99%

Ethnopharmacological Approaches for Therapy of Jaundice: Part I

et al. 2017

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Jaundice is a very common symptom especially in the developing countries. It is associated with several hepatic diseases which are still major causes of death. There are many different approaches to jaundice treatment and the growing number of ethnomedicinal studies shows the plant pharmacology as very promising direction. Many medicinal plants are used for the treatment of jaundice, however a comprehensive review on this subject has not been published. The use of medicinal plants in drug discovery is highly emphasized (based on their traditional and safe uses in different folk medicine systems from ancient times). Many sophisticated analytical techniques are emerging in the pharmaceutical field to validate and discover new biologically active chemical entities derived from plants. Here, we aim to classify and categorize medicinal plants relevant for the treatment of jaundice according to their origin, geographical location, and usage. Our search included various databases like Pubmed, ScienceDirect, Google Scholar. Keywords and phrases used for these searches included: “jaundice,” “hyperbilirubinemia,” “serum glutamate,” “bilirubin,” “Ayurveda.” The first part of the review focuses on the variety of medicinal plant used for the treatment of jaundice (a total of 207 medicinal plants). In the second part, possible mechanisms of action of biologically active secondary metabolites of plants from five families for jaundice treatment are discussed.

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