Olfactory dysfunction as a marker of multiple sclerosis progression

Pimentel, Maria Lúcia Vellutini

doi:10.1590/0004-282x20160133

Cited by 4 publications

(3 citation statements)

References 11 publications

(12 reference statements)

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“…The presence of demyelinating plaques observed by MRI in the inferior frontal-and temporal-lobe regions of patients affected from MS is correlated with altered smell abilities and olfactory dysfunctions. As in case of gustatory alterations, the olfactory dysfunction may be an indicator of disease progression due to the increasing of number of lesion or to the extension of demyelinating areas 32,33 .…”

Section: Smell Alterations In Msmentioning

confidence: 99%

Ageusia, Hyposmia, Dizziness and Tinnitus as Presenting Symptoms of Multiple Sclerosis

Ralli¹,

DâAguanno²,

Altieri³

et al. 2018

The International Tinnitus Journal

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Multiple Sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system characterized by the destruction of myelin sheaths and axonal loss. Presenting symptoms of multiple sclerosis may vary and if not promptly identified may lead to a delayed diagnosis of Multiple sclerosis. In this paper, we present a rare case of a patient with ageusia as presenting symptom of Multiple sclerosis; the symptom spontaneously resolved after two weeks and was followed by hyposmia, dizziness, tinnitus and facial paraesthesia that eventually led to a clinical diagnosis of Multiple sclerosis. The presence of gustatory, olfactory and audio-vestibular symptoms has been associated with disease activity and progression of several inflammatory and neurodegenerative diseases of the central nervous system including Multiple sclerosis. Gustatory alterations may be due to the presence of demyelinating lesion in the brain area of taste; the progression of the disease may explain the additional olfactory and audio-vestibular symptoms described in this patient. Even if taste alteration is an extremely rare presenting symptom of Multiple sclerosis, its presence in young women should always be carefully investigated as it could be an early sign of Multiple sclerosis.

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Section: Smell Alterations In Msmentioning

confidence: 99%

Ageusia, Hyposmia, Dizziness and Tinnitus as Presenting Symptoms of Multiple Sclerosis

Ralli¹,

DâAguanno²,

Altieri³

et al. 2018

The International Tinnitus Journal

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“…Smell alterations may be present in MS with a prevalence ranging from 15% to 45% [74][75][76][77][78][79] and are mainly described during the active phases of the disease. Olfactory disorders in MS often begins with an altered perception of smell (dysosmia) that progressively worsen to complete anosmia 80,81 .…”

Section: Smell Alterationsmentioning

confidence: 99%

“…The diagnosis of olfactory alterations can be made using olfactometry 84 , and a worsening of this condition may be an indicator of disease progression due to the increasing of number of lesion or to the extension of demyelinating areas 74,79 .…”

Section: Smell Alterationsmentioning

confidence: 99%

Otolaryngologic Symptoms in Multiple Sclerosis: A Review

Ralli¹,

Stadio²,

Visconti³

et al. 2018

The International Tinnitus Journal

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Many symptoms of multiple sclerosis may affect the ear, nose and throat. The most common otolaryngologic symptoms of multiple sclerosis are speech disorders, followed by sleep disorders, vertigo and disequilibrium, dysphagia, smell alterations, and hearing loss. Less common symptoms include sialorrhea, facial palsy, taste alterations, trigeminal neuralgia and tinnitus. The origin of otolaryngologic symptoms in multiple sclerosis is mainly central, although increasing evidence also suggests a peripheral involvement.

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Olfactory Dysfunction in CNS Neuroimmunological Disorders: a Review

et al. 2018

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Olfactory dysfunction is deeply associated with quality of human life in the aging population. Olfactory dysfunction is an occasional presymptomatic sign of neuroimmunological multiple sclerosis, neuromyelitis optica, and systemic lupus erythematosus. Olfaction is initially processed by olfactory receptor cells that capture odor molecules, and the signals are transmitted to the glomeruli in the olfactory bulbs via olfactory nerves and processed in the primary olfactory cortex in the brain. Damage to either the olfactory receptor cells or the olfactory bulb and primary olfactory cortex may influence olfactory functioning. A close link between neuroimmunological disorders and olfactory dysfunction has been reported in patients and animal models. This review summarizes the literature data concerning olfactory dysfunction in autoimmune diseases including multiple sclerosis, neuromyelitis optica, and systemic lupus erythematosus; animal models thereof; and inflammation in the olfactory bulb.

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Olfactory dysfunction as a marker of multiple sclerosis progression

Cited by 4 publications

References 11 publications

Ageusia, Hyposmia, Dizziness and Tinnitus as Presenting Symptoms of Multiple Sclerosis

Ageusia, Hyposmia, Dizziness and Tinnitus as Presenting Symptoms of Multiple Sclerosis

Otolaryngologic Symptoms in Multiple Sclerosis: A Review

Olfactory Dysfunction in CNS Neuroimmunological Disorders: a Review

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