Serum levels of adiponectin, CCL3/MIP-1α, and CCL5/RANTES discriminate migraine from tension-type headache patients

Domingues, Renan Barros; Duarte, Halina; Senne, Carlos; Bruniera, Gustavo; Brunale, Fernando; Rocha, Natália Pessoa; Teixeira, Antônio Lúcio

doi:10.1590/0004-282x20160096

Cited by 12 publications

(9 citation statements)

References 29 publications

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“…In our study upregulation of several cytokines, as well as COX-2 were detected in PBMCs of migraine patients in both interictal and ictal samples compared to healthy controls pointing to a systemic change of immune functions. These data are in line with previous reports of elevated plasma levels of various proinflammatory cytokines like IL-1, IL-6 [ 33 ], TNFα [ 34 ], IL-8, CCL3 and CCL5 [ 41 , 42 ] and C-reactive proteins (CRP) [ 43 , 44 ]. Moreover, during attacks, the concentration of IL-1β, IL-6, IL-8, IL-10 and TNF-α were further increased [ 35 , 36 ].…”

Section: Discussionsupporting

confidence: 92%

Identification of disease- and headache-specific mediators and pathways in migraine using blood transcriptomic and metabolomic analysis

et al. 2021

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Background Recent data suggest that gene expression profiles of peripheral white blood cells can reflect changes in the brain. We aimed to analyze the transcriptome of peripheral blood mononuclear cells (PBMC) and changes of plasma metabolite levels of migraineurs in a self-controlled manner during and between attacks. Methods Twenty-four patients with migraine were recruited and blood samples were collected in a headache-free (interictal) period and during headache (ictal) to investigate disease- and headache-specific alterations. Control samples were collected from 13 age- and sex-matched healthy volunteers. RNA was isolated from PBMCs and single-end 75 bp RNA sequencing was performed using Illumina NextSeq 550 instrument followed by gene-level differential expression analysis. Functional analysis was carried out on information related to the role of genes, such as signaling pathways and biological processes. Plasma metabolomic measurement was performed with the Biocrates MxP Quant 500 Kit. Results We identified 144 differentially-expressed genes in PBMCs between headache and headache-free samples and 163 between symptom-free patients and controls. Network analysis revealed that enriched pathways included inflammation, cytokine activity and mitochondrial dysfunction in both headache and headache-free samples compared to controls. Plasma lactate, succinate and methionine sulfoxide levels were higher in migraineurs while spermine, spermidine and aconitate were decreased during attacks. Conclusions It is concluded that enhanced inflammatory and immune cell activity, and oxidative stress can play a role in migraine susceptibility and headache generation.

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Section: Discussionsupporting

confidence: 92%

Identification of disease- and headache-specific mediators and pathways in migraine using blood transcriptomic and metabolomic analysis

et al. 2021

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“…The levels of CCL3 are lower in patients with VM compared to MD, but higher than in healthy controls. Elevated levels of CCL3 have been reported in patients with migraine (21), which could support the hypothesis that VM shares migraine mechanisms (3).…”

Section: Discussionsupporting

confidence: 66%

Differential Proinflammatory Signature in Vestibular Migraine and Meniere Disease

et al. 2019

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Vestibular Migraine (VM) and Meniere's Disease (MD) are episodic vestibular syndromes defined by a set of associated symptoms such as tinnitus, hearing loss or migraine features during the attacks. Both conditions may show symptom overlap and there is no biological marker to distinguish them. Two subgroups of MD patients have been reported, according to their IL-1β profile. Therefore, considering the clinical similarity between VM and MD, we aimed to investigate the cytokine profile of MD and VM as a means to distinguish these patients. We have also carried out gene expression microarrays and measured the levels of 14 cytokines and 11 chemokines in 129 MD patients, 82 VM patients, and 66 healthy controls. Gene expression profile in peripheral blood mononuclear cells (PBMC) showed significant differences in MD patients with high and low basal levels of IL- 1β and VM patients. MD patients with high basal levels of IL- 1β (MDH) had overall higher levels of cytokines/chemokines when compared to the other subsets. CCL4 levels were significantly different between MDH, MD with low basal levels of IL- 1β (MDL), VM and controls. Logistic regression identified IL- 1β, CCL3, CCL22, and CXCL1 levels as capable of differentiating VM patients from MD patients (area under the curve = 0.995), suggesting a high diagnostic value in patients with symptoms overlap.

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“…Headaches in ZIKV-infected individuals were associated with the presence of increased plasma TNF-α, IL-17A, IL-2, IL-9, IL-12p70, MIP-1α, G-CSF, GM-CSF, and VEGF, as well as significantly higher levels of IL-5, suggesting that these cytokines can play a role in the mechanisms underlying headache. Accordingly, high plasma levels of IL-5 ( 36 ), MIP-1α ( 37 ), and RANTES ( 38 ) have been reported in migraine sufferers, but their mechanistic contributions are yet to be investigated. Studies on inflammatory mediators in the pathophysiology of headache have shown the main action of IL-5 during migraine episodes ( 36 , 39 ).…”

Section: Discussionmentioning

confidence: 99%

Acute Zika Virus Infection in an Endemic Area Shows Modest Proinflammatory Systemic Immunoactivation and Cytokine-Symptom Associations

et al. 2018

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An early immune response to Zika virus (ZIKV) infection may determine its clinical manifestation and outcome, including neurological effects. However, low-grade and transient viremia limits the prompt diagnosis of acute ZIKV infection. We have investigated the plasma cytokine, chemokine, and growth factor profiles of 36 individuals from an endemic area displaying different symptoms such as exanthema, headache, myalgia, arthralgia, fever, hyperemia, swelling, itching, and nausea during early-phase infection. These profiles were then associated with symptoms, revealing important aspects of the immunopathophysiology of ZIKV infection. The levels of some cytokines/chemokines were significantly higher in acute ZIKV-infected individuals compared to healthy donors, including interferon (IFN) gamma-induced protein 10 (IP-10), regulated on activation, normal T cell expressed and secreted (RANTES), IFN-γ, interleukin (IL)-9, IL-7, IL-5, and IL-1ra, including some with predominantly immunoregulatory activity. Of note, we found that higher levels of IP-10 and IL-5 in ZIKV-infected individuals were strongly associated with exanthema and headache, respectively. Also, higher levels of IL-1ra were associated with subjects with arthralgia, whereas those with fever showed lower levels of granulocyte-colony stimulating factor (G-CSF). No correlation was observed between the number of symptoms and ZIKV viral load. Interestingly, only IP-10 showed significantly decreased levels in the recovery phase. In conclusion, our results indicate that acute ZIKV infection in a larger cohort resident to an endemic area displays a modest systemic immune activation profile, involving both proinflammatory and immunoregulatory cytokines and chemokines that could participate of virus control. In addition, we showed that differential cytokine/chemokine levels are related to specific clinical symptoms, suggesting their participation in underlying mechanisms.

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Serum levels of adiponectin, CCL3/MIP-1α, and CCL5/RANTES discriminate migraine from tension-type headache patients

Cited by 12 publications

References 29 publications

Identification of disease- and headache-specific mediators and pathways in migraine using blood transcriptomic and metabolomic analysis

Identification of disease- and headache-specific mediators and pathways in migraine using blood transcriptomic and metabolomic analysis

Differential Proinflammatory Signature in Vestibular Migraine and Meniere Disease

Acute Zika Virus Infection in an Endemic Area Shows Modest Proinflammatory Systemic Immunoactivation and Cytokine-Symptom Associations

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