Presence or absence of cognitive complaints in Parkinson’s disease: mood disorder or anosognosia?

Castro, Pollyanna Celso Felipe de; Aquino, Camila C.; Felı́cio, André Carvalho; Doná, Flávia; Medeiros, Leonardo Mariano Inácio; Silva, Sônia M. C.A.; Ferraz, Henrique Ballalai; Bertolucci, Paulo Henrique Ferreira; Borges, Vanderci

doi:10.1590/0004-282x20160060

Cited by 18 publications

(34 citation statements)

References 24 publications

(20 reference statements)

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“…Such findings have also been reported in other dementing disorders (Hendrie et al, 1997) as well as in healthy aging (Balash et al, 2013). As suggested in several previous studies (Marino et al, 2009;Sitek et al, 2011;Santangelo et al, 2014;Castro et al, 2016), affective symptoms could worsen the subjective perception of cognitive deficits in PD patients. Another possibility is that facing cognitive difficulties in everyday situations gives rise to depressive symptoms or apathy, but such cognitive problems were not captured by the task battery used in the present study.…”

Section: Associations Between Cognitive Deficits and Psychiatric Sympsupporting

confidence: 82%

Disentangling the Role of Working Memory in Parkinson’s Disease

Salmi

Ritakallio

Fellman

et al. 2020

Front. Aging Neurosci.

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Working memory (WM) represents a core cognitive function with a major striatal contribution, and thus WM deficits, commonly observed in Parkinson's disease (PD), could also relate to many other problems in PD patients. Our online study aimed to determine the subdomains of WM that are particularly affected in PD and to clarify the links between WM and everyday cognitive deficits, other executive functions, psychiatric and PD symptoms, as well as early cognitive impairment. Fifty-two mild-to-moderate PD patients and 54 healthy controls performed seven WM tasks tapping selective updating, continuous monitoring, or maintenance of currently active information. Self-ratings of everyday cognition, depression, and apathy symptoms, as well as screenings of global cognitive impairment, were also collected. The data were analyzed using structural equation modeling. Of the three WM domains, only selective updating was directly predictive of PD group membership. More widespread WM deficits were observed only in relation to global cognitive impairment in PD patients. Self-rated everyday cognition or psychiatric symptoms were not linked to WM performance but correlated with each other. Our findings suggest that WM has a rather limited role in the clinical manifestation of PD. Nevertheless, due to its elementary link to striatal function, the updating component of WM could be a candidate for a cognitive marker of PD also in patients who are otherwise cognitively well-preserved.

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Section: Associations Between Cognitive Deficits and Psychiatric Sympsupporting

confidence: 82%

Disentangling the Role of Working Memory in Parkinson’s Disease

Salmi

Ritakallio

Fellman

et al. 2020

Front. Aging Neurosci.

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“…Three studies found an association between subjective complaints and poorer cognitive performances, 5 6 7 whereas others failed to show clear relationship 8 or found that cognitive scores were higher in patients with SCCs than in those without SCCs. 9 …”

Section: Introductionmentioning

confidence: 99%

“…These studies used various methods to define SCCs, with some assessing SCCs using a simple yes/no question, 6 8 9 and others using questionnaires focusing on memory symptoms only. 5 7 However, because the pattern of cognitive impairment in patients with PD is not identical to that of AD, other tools employing questions covering various cognitive symptoms beyond memory complaints are needed.…”

Section: Introductionmentioning

confidence: 99%

Subjective Cognitive Complaints and Objective Cognitive Impairment in Parkinson's Disease

et al. 2018

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Background and PurposeSubjective cognitive complaints (SCCs) are very common in patients with Parkinson's disease (PD). However, the relationship between SCCs and objective cognitive impairment is still unclear. This study aimed to determine whether SCCs are correlated with objective cognitive performance in patients with PD.MethodsTotals of 148 cognitively normal patients, 71 patients with mild cognitive impairment (MCI), and 31 demented patients were recruited consecutively from a movement-disorders clinic. Their SCCs and cognitive performances were evaluated using the Cognitive Complaints Interview (CCI) and a comprehensive neuropsychological battery.ResultsThe CCI score increased with age, duration of PD, and depression score, and was inversely correlated with cognitive performance. The association between CCI score and performance remained significant after adjustment for the depression score, age, and duration of PD. The CCI score could be used to discriminate patients with dementia from cognitively normal and MCI patients [area under the receiver operating characteristics curve (AUC) of 0.80], but not patients with MCI or dementia from cognitively normal patients (AUC of 0.67).ConclusionsSCCs as measured by the CCI are strongly correlated with objective cognitive performance in patients with PD. The CCI can also be used to screen for dementia in patients with PD.

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“…A significant factors contributing to reporting different SCD are brain diseases of different aetiologies. In comparison to healthy people, an increased SCD is the feature of people with Parkinson disease [19], after head injuries [20,21], with cardiovascular diseases [22], after strokes [23,24], in multiple sclerosis [25,26] and in early stages of Alzheimer disease [27]. Similarly to healthy, in clinic groups the connection between increased SCD and depression, anxiety, feeling of stress was noted [28].…”

Section: Introductionmentioning

confidence: 98%

Subjective Cognitive Complaints in Distant Phase After Stroke – Preliminary Study

Szepietowska¹

2018

KLS

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Introduction. Subjective cognitive decline (SCD) is often reported by healthy individuals and by different clinical groups. Current data do not clearly show the relationship between SCD and cognitive functioning, but the predictors of SCD are: age, depression and sociodemographic factors. Inconclusive data also applies topeople suffering from stroke in the distal post-stroke phase. Correct identification of the causes of SCD will help to take adequate forms of psychological therapy (neuropsychological rehabilitation and/or psychotherapy). Methodology. The aims of research was to compare the intensity and structure of SCD as well as theirdeterminants in healthy persons and those after stroke. In our study 193 adults participated: 118 osób without brain pathology and 75 patients who suffered stroke 2–3 years earlier. DEX-S and ProCog as methods of evaluation of SCD and cognitive assessment techniques: the Montreal Cognitive Assessment Scale (MoCA), WAIS-R subtests and intensity of depressive mood (Geriatric Depression Scale – 15) were used in the study. Results. Patients after stroke were characterized by more severe SCD than healthy people. People in both groups likewise (low) rated one’s own long-term memory, general cognitive and executive function. It has also been shown that people after stroke have significantly lower cognitive competencies compared to healthyindividuals, but similar (low) level of depressive mood. The later part of the analysis showed that some complaints may be determined by depressive mood, others are due to the interaction of cognitive deficits and depressive mood. Conclusion. Our results confirm the need for proper qualifications complaints in patients after stroke (in distant post-stroke phase). Keywords: subjective cognitive decline, stroke, cognitive functioning, depression

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Presence or absence of cognitive complaints in Parkinson’s disease: mood disorder or anosognosia?

Cited by 18 publications

References 24 publications

Disentangling the Role of Working Memory in Parkinson’s Disease

Disentangling the Role of Working Memory in Parkinson’s Disease

Subjective Cognitive Complaints and Objective Cognitive Impairment in Parkinson's Disease

Subjective Cognitive Complaints in Distant Phase After Stroke – Preliminary Study

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