Intracerebral Granulocytic Sarcoma in recurrence of Chronic Myeloid Leukemia

Abstract

A 21-year-old male with a 2-year diagnosis of chronic myeloid leukemia in complete hematologic and cytogenetic responses was admitted to hospital with drowsiness, headache and seizures. Laboratory evaluation disclosed leucocitosis with 19.0% of peripheral blasts. Brain magnetic resonance imaging (MRI) (Figure 1) corroborated the diagnosis of granulocytic sarcoma (GS) in blast crisis. MRI performed 38 days after chemotherapy was indicative of tumor regression ( Figure 2).GS is an extramedullary solid tumor composed of immature myeloid cells 1 . It develops before, during or after the onset of myeloid leukemia 2 . Intra-axial GS without involvement of skull or meninges is rare 3 .