Impaired cognition in depression and Alzheimer (AD): a gradient from depression to depression in AD

Araújo, Narahyana Bom de; Moraes, Helena; Silveira, Heitor; Arcoverde, Cynthia; Vasques, Paulo Eduardo; Barca, Maria Lage; Knapskog, Anne-Brita; Engedal, Knut; Coutinho, Evandro Silva Freire; Deslandes, Andréa Camaz; Laks, Jérson

doi:10.1590/0004-282x20140108

Cited by 17 publications

(8 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Depressive symptoms correlated inversely with LASSI-L cued learning in individuals with a maternal history of Alzheimer's disease, but not in those with a paternal history of the disease or the control group, suggesting that depression may affect cognitive performance differently depending on the family history and sex of the parent with Alzheimer's. Previous studies also found that depression may affect cognition in preclinical and clinical Alzheimer's disease, as individuals with Alzheimer's disease but without depression tended to perform better on cognitive assessments than those with Alzheimer's disease and depression [43].…”

Section: Discussionmentioning

confidence: 79%

Individual cognitive and depressive traits associated with maternal versus paternal family history of Late-onset Alzheimer’s disease: Proactive semantic interference versus standard neuropsychological assessments

Wilson

Abulafia

Loewenstein

et al. 2018

Personalized Medicine in Psychiatry

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 79%

Individual cognitive and depressive traits associated with maternal versus paternal family history of Late-onset Alzheimer’s disease: Proactive semantic interference versus standard neuropsychological assessments

Wilson

Abulafia

Loewenstein

et al. 2018

Personalized Medicine in Psychiatry

View full text Add to dashboard Cite

“…Patients with comorbid MDD and AD demonstrated worse cognitive performance when compared to controls and patients with only AD or MDD [35]. A higher stroke risk was revealed in AD patients with MDD when compared to controls [36].…”

Section: Accepted Manuscriptmentioning

confidence: 85%

Neurochemical correlation between major depressive disorder and neurodegenerative diseases

et al. 2016

View full text Add to dashboard Cite

“…The sequence of cognitive decline in patients with AD may be influenced by several factors. Comorbidities, such as depression, may impact on cognitive performance [ 45 ]. Sociodemographic variables such as age, sex, educational level, race/ethnicity, social class, and place of residence have been shown to be related to the MMSE score [ 5, 18 ], but there are conflicting reports and possible interactions between the different variables.…”

Section: Discussionmentioning

confidence: 99%

Describing the Sequence of Cognitive Decline in Alzheimer’s Disease Patients: Results from an Observational Study

Henneges

Reed

Chen

et al. 2016

JAD

View full text Add to dashboard Cite

Background: Improved understanding of the pattern of cognitive decline in Alzheimer’s disease (AD) would be useful to assist primary care physicians in explaining AD progression to patients and caregivers.Objective: To identify the sequence in which cognitive abilities decline in community-dwelling patients with AD.Methods: Baseline data were analyzed from 1,495 patients diagnosed with probable AD and a Mini-Mental State Examination (MMSE) score ≤ 26 enrolled in the 18-month observational GERAS study. Proportional odds logistic regression models were applied to model MMSE subscores (orientation, registration, attention and concentration, recall, language, and drawing) and the corresponding subscores of the cognitive subscale of the Alzheimer’s Disease Assessment Scale (ADAS-cog), using MMSE total score as the index of disease progression. Probabilities of impairment start and full impairment were estimated at each MMSE total score level.Results: From the estimated probabilities for each MMSE subscore as a function of the MMSE total score, the first aspect of cognition to start being impaired was recall, followed by orientation in time, attention and concentration, orientation in place, language, drawing, and registration. For full impairment in subscores, the sequence was recall, drawing, attention and concentration, orientation in time, orientation in place, registration, and language. The sequence of cognitive decline for the corresponding ADAS-cog subscores was remarkably consistent with this pattern.Conclusion: The sequence of cognitive decline in AD can be visualized in an animation using probability estimates for key aspects of cognition. This might be useful for clinicians to set expectations on disease progression for patients and caregivers.

show abstract

Impaired cognition in depression and Alzheimer (AD): a gradient from depression to depression in AD

Abstract: A decreasing gradient in cognition appeared from the control to depression in AD, with MD and AD in an intermediate position.

Cited by 17 publications

References 28 publications

Individual cognitive and depressive traits associated with maternal versus paternal family history of Late-onset Alzheimer’s disease: Proactive semantic interference versus standard neuropsychological assessments

Individual cognitive and depressive traits associated with maternal versus paternal family history of Late-onset Alzheimer’s disease: Proactive semantic interference versus standard neuropsychological assessments

Neurochemical correlation between major depressive disorder and neurodegenerative diseases

Describing the Sequence of Cognitive Decline in Alzheimer’s Disease Patients: Results from an Observational Study

Contact Info

Product

Resources

About