Individual cognitive and depressive traits associated with maternal versus paternal family history of Late-onset Alzheimer’s disease: Proactive semantic interference versus standard neuropsychological assessments

Wilson, Kathleen; Abulafia, Carolina; Loewenstein, David; Vigo, Daniel Eduardo; Sevlever, Gustavo; Nemeroff, Charles B.; Villarreal, Mirta F.; Guinjoan, Salvador M.

doi:10.1016/j.pmip.2018.09.002

Cited by 2 publications

(2 citation statements)

References 35 publications

(29 reference statements)

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“…In fact, no measure of retroactive interference reached statistical significance, which is consistent with the notion that PSI is uniquely related to early cognitive function in older adults with aMCI at risk for AD (17,27). Previous studies have suggested that PSI effects may be more associated with MCI and early AD than RSI (27)(28). In contrast, in 2012 Ricci and colleagues (29) found RSI but lack of PSI effects using the Rey Auditory Verbal learning Test (RAVLT).…”

Section: Discussionsupporting

confidence: 57%

Amnestic Mild Cognitive Impairment is Characterized by the Inability to Recover from Proactive Semantic Interference across Multiple Learning Trials

et al. 2020

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Background: Difficulties in inhibition and self-monitoring are early features of incipient Alzheimer’s disease and may manifest as susceptibility to proactive semantic interference. However, due to limitations of traditional memory assessment paradigms, recovery from interference effects following repeated learning opportunities has not been explored. Objective: This study employed a novel computerized list learning test consisting of repeated learning trials to assess recovery from proactive and retroactive semantic interference. Design: The design was cross-sectional. Setting: Participants were recruited from the community as part of a longitudinal study on normal and abnormal aging. Participants: The sample consisted of 46 cognitively normal individuals and 30 participants with amnestic mild cognitive impairment. Measurements: Participants were administered the Cognitive Stress Test and traditional neuropsychological measures. Step-wise logistic regression was applied to determine which Cognitive Stress Test measures best discriminated between diagnostic groups. This was followed by receiver operating characteristic analyses. Results: Cued A3 recall, Cued B3 recall and Cued B2 intrusions were all independent predictors of diagnostic status. The overall predictive utility of the model yielded 75.9% sensitivity, 91.1% specificity, and an overall correct classification rate of 85.1%. When these variables were jointly entered into receiver operating characteristic analyses, the area under the curve was .923 (p<.001). Conclusions: This novel paradigm’s use of repeated learning trials offers a unique opportunity to assess recovery from proactive and retroactive semantic interference. Participants with mild cognitive impairment exhibited a continued failure to recover from proactive interference that could not be explained by mere learning deficits.

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Section: Discussionsupporting

confidence: 57%

Amnestic Mild Cognitive Impairment is Characterized by the Inability to Recover from Proactive Semantic Interference across Multiple Learning Trials

et al. 2020

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“…As LOAD pathophysiological process begins decades before the first clinical symptoms appear [40], individuals were recruited to participate in a larger, exploratory, crosssectional study with the aim of assessing early neuroimaging, cognitive and circadian markers in asymptomatic, middle-aged O-LOAD, which are believed to be at greater genetic risk of developing LOAD [41,32,42,36,43,44,45,46]. Accompanying family members of LOAD patients were informed of the study and invited to participate by the patients' physicians.…”

Section: Participantsmentioning

confidence: 99%

Oculomotor Abnormalities during Reading in the Offspring of Late-Onset Alzheimer’s Disease

Fernández

González

Abulafia

et al. 2022

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Introduction: Eye movement patterns during reading are well defined and documented. Each eye movement ends up in a fixation point, which allows the brain to process the incoming information and to program the following saccade. In this work, we investigated whether eye movement alterations during a reading task might be already present in middle-aged, cognitively normal offspring of late-onset Alzheimer’s disease (O-LOAD). Methods: 18 O-LOAD and 18age-matched healthy individuals with no family history of LOAD participated in the study. Participants were seated in front of a 20-inch LCD monitor and single sentences were presented on it. Eye movements were recorded with an eye tracker, with a sampling rate of 1000 Hz. Results: Analysis of eye movements during reading revealed that O-LOAD displayed more fixations, shorter saccades and shorter fixation durations than controls. Conclusion: The present study shows that O-LOAD evidenced alterations in their eye movements during reading. O-LOAD eye movement behavior could be considered an initial sign of oculomotor impairment. Hence, evaluation of eye movement during reading might provide a useful tool for monitoring well-defined cognitive resources.

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Individual cognitive and depressive traits associated with maternal versus paternal family history of Late-onset Alzheimer’s disease: Proactive semantic interference versus standard neuropsychological assessments

Cited by 2 publications

References 35 publications

Amnestic Mild Cognitive Impairment is Characterized by the Inability to Recover from Proactive Semantic Interference across Multiple Learning Trials

Amnestic Mild Cognitive Impairment is Characterized by the Inability to Recover from Proactive Semantic Interference across Multiple Learning Trials

Oculomotor Abnormalities during Reading in the Offspring of Late-Onset Alzheimer’s Disease

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