Iatrogenic meningitis

Mutarelli, Eduardo Genaro; Adoni, Tarso

doi:10.1590/0004-282x20130145

Cited by 3 publications

(4 citation statements)

References 2 publications

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“…The meningitis is defined as inflammation of the meninges and is distinct from encephalitis, which is an inflammation of the brain tissue. The causes of meningitis are either infective or noninfective (called aseptic) including neoplasia, autoimmune, or auto‐inflammatory systemic diseases (e.g., systemic lupus erythematosus (SLE), rheumatoid arthritis, Behçet's disease) and iatrogenic etiologies such as complications of a lumbar puncture or intrathecal drug adverse effects . Few studies consider the aseptic meningitis as infectious disease of the central nervous system (CNS) negative for bacteria, thus, including viral and fungal meningitis .…”

Section: Definition and Diagnosis Of Diammentioning

confidence: 99%

“…Although polymorphonuclear predominance is very common, lymphocytes and eosinophilic presence have also been reported. Moreover, the proteins level in CSF is usually elevated, whereas the concomitant glucose level in CSF remains normal . Neuroimaging is usually noninformative , and CSF bacterial culture results are obviously negative.…”

Section: Definition and Diagnosis Of Diammentioning

confidence: 99%

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Drug‐induced aseptic meningitis: a mini‐review

Yéléhé‐Okouma

Czmil-Garon

Pape

et al. 2018

Fundamemntal Clinical Pharma

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Aseptic meningitis associates a typical clinical picture of meningitis with the absence of bacterial or fungal material in the cerebrospinal fluid. Drug-induced aseptic meningitis (DIAM) may be due to two mechanisms: (i) a direct meningeal irritation caused by the intrathecal administration of drugs and (ii) an immunologic hypersensitivity reaction to a systemic administration. If the direct meningeal irritation allows a rather easy recognition, the immunologic hypersensitivity reaction is a source of challenging diagnostics. DIAM linked to a systemic treatment exerts typically an early onset, usually within a week. This period can be shortened to a few hours in case of drug rechallenge. The fast and spontaneous regression of clinical symptoms is usual after stopping the suspected drug. Apart from these chronological aspects, no specific clinical or biological parameters are pathognomonic. CSF analysis usually shows pleiocytosis. The proteinorachia is increased while glycorachia remains normal. Underlying pathologies can stimulate the occurrence of DIAM. Thus, systemic lupus erythematosus appears to promote DIAM during NSAID therapy, especially ibuprofen-based one. Similarly, some patients with chronic migraine are prone to intravenous immunoglobulin-induced aseptic meningitis. DIAM will be mainly evoked on chronological criteria such as rapid occurrence after initiation, rapid regression after discontinuation, and recurrence after rechallenge of the suspected drug. When occurring, positive rechallenge may be very useful in the absence of initial diagnosis. Finally, DIAM remains a diagnosis of elimination. It should be suggested only after all infectious causes have been ruled out.

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Section: Definition and Diagnosis Of Diammentioning

confidence: 99%

Section: Definition and Diagnosis Of Diammentioning

confidence: 99%

Drug‐induced aseptic meningitis: a mini‐review

Yéléhé‐Okouma

Czmil-Garon

Pape

et al. 2018

Fundamemntal Clinical Pharma

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“…Se entiende por iatrogenia al daño en la salud causado por un acto médico y por meningitis, a la inflamación de las meninges que recubren el cerebro y que se identifica por la elevación del número de leucocitos en el líquido cefalorraquídeo (LCR) [1][2][3][4]. La meningitis iatrogénica es, por tanto, una infección surgida de la complicación de un procedimiento médico, normalmente invasivo, como, por ejemplo: la craneotomía, la colocación de catéteres ventriculares internos o externos, la punción lumbar, las infusiones intratecales de medicamentos o la anestesia espinal [5][6][7][8][9][10]. Cuando la infección se ha contraído en el ámbito hospitalario, se denomina meningitis nosocomial, englobándose la meningitis iatrogénica dentro de ésta [2].…”

Section: Introductionunclassified

Untitled

2019

RevDisCliNeuro

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Different studies in the scientific literature show that adults who have suffered an episode of septic or aseptic meningitis, can present motor and cognitive alterations even after a successful recovery. Neuropsychological rehabilitation has been shown to be effective in improving cognitive functions. The aim of this study is to analyze the differences between the pre-test and post-test evaluation of a single case of iatrogenic bacterial meningitis after lumbar puncture, after ten months of neuropsychological rehabilitation and psychotherapy. The results show a discrete improvement of some altered cognitive abilities and a significant improvement in the anxious and depressive symptomatology. Conclusions: In this study there are positive results about the effects of integral rehabilitation in cognitive functions and emotional state in a case of iatrogenic meningitis. Future studies should include a larger sample and longerterm post-test evaluations.

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Section: Introductionunclassified

Efectos a corto plazo de la intervención integral en un caso de meningitis iatrogénica

Bermúdez

2019

RevDisCliNeuro

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Diferentes estudios recogidos en la literatura científica evidencian que pacientes adultos que han sufrido un episodio de meningitis séptica o aséptica, pueden presentar alteraciones motoras y cognitivas incluso tras una recuperación exitosa. La rehabilitación neuropsicológica se ha mostrado eficaz para la mejora de las funciones cognitivas. El objetivo de este estudio es analizar las diferencias entre la evaluación pre-test de un caso único de un paciente con meningitis iatrogénica bacteriana tras punción lumbar, y la evaluación post-test de dicho paciente, realizada tras diez meses de rehabilitación neuropsicológica y psicoterapia. Los resultados muestran una mejora discreta de algunas capacidades cognitivas alteradas y una mejora significativa en la sintomatología ansiosa y depresiva. Conclusiones: Este estudio obtiene resultados sobre los efectos de la rehabilitación integral en los procesos cognitivos y en el estado de ánimo en un paciente con meningitis iatrogénica. Futuros estudios deben incluir una mayor muestra y evaluaciones post-test a más largo plazo.

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Iatrogenic meningitis

Cited by 3 publications

References 2 publications

Drug‐induced aseptic meningitis: a mini‐review

Drug‐induced aseptic meningitis: a mini‐review

Untitled

Efectos a corto plazo de la intervención integral en un caso de meningitis iatrogénica

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