This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.Elevated immunoglobulin E (IgE) can be detected in various conditions such as allergic asthma, atopic eczema, anaphylaxis, parasite infection, vasculitis, IgE myeloma, and hyper-IgE syndrome (HIES).1 The binding of IgE to specific antigens causes mast-cell degranulation, resulting in an inflammatory reaction. 2 Here we present a patient with Guillain-Barré syndrome (GBS) who exhibited elevated serum IgE.
CASEA 72-year-old man was admitted for paresthesia in both feet and a gait disturbance that had progressed for the previous 3 days. He was generally healthy except for frequent skin abscesses and eczema. Peripheral neuropathy associated with hyper-IgE-emia have been rarely reported. Here we present a 72-year-old man with acute motor axonal neuropathy who had relatively poor prognosis. The serum was weakly positive for IgG GQ1b and GT1a, and serum IgE was significantly elevated. He was transferred to a rehabilitation center with Medical Research Council grade 3 lower extremity weakness on admission day 65. We would suggest that hyper-IgE-emia may increase the magnitude and rate of neural damage in this case.