Cognitive sequelae of COVID-19, a post-pandemic threat. Should we be worried about the brain fog?

Brutto, Oscar H. Del

doi:10.1590/0004-282x-anp-2022-e003

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…Neurological manifestations have been observed not only throughout the acute phase of illness [5][6][7][8][9] but also during the post-infection period [10,11]. Among these persistent symptoms, cognitive, memory and concentration disturbances have been reported by approximately one in four patients with a previous SARS-CoV-2 infection [12], and their presence interfered with daily activities and delayed the chance of complete recovery [13,14]. In the literature, the term 'brain fog' was coined in order to gather these symptoms and was intended to convey the notion of cognitive impairment including difficulties with concentration and intellectual clarity, mental fatigue, and anxiety [10,11,15].…”

Section: Introductionmentioning

confidence: 99%

Sex-related patient-reported brain fog symptoms in non-hospitalised COVID-19 patients

Chatys-Bogacka

Mazurkiewicz

Słowik

et al. 2023

Neurol Neurochir Pol.

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Introduction.Previous studies on the prognostic role of sex in post-COVID-associated brain fog have yielded divergent results. Moreover, limited evidence exists regarding the evolution of brain fog symptoms over time, especially in ambulatory patients and separately for women and men. Therefore, the aim of the current study was to assess brain fog symptoms in nonhospitalised patients with COVID-19, according to their sex. Material and methods.We created a neuropsychological questionnaire including eight questions on the presence of brain fog symptoms in the following four time periods: before COVID-19, and 0-4, 4-12, and > 12 weeks post-infection. The validity and reliability of the questionnaire were assessed. In this cross-sectional study, questionnaires were filled out anonymously and retrospectively once only by patients or through a survey link posted online. Included were patients ≥ 18 years, with > 3 months since the SARS-CoV-2 infection onset confirmed by RT-PCR from a nasopharyngeal swab.

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Section: Introductionmentioning

confidence: 99%

Sex-related patient-reported brain fog symptoms in non-hospitalised COVID-19 patients

Chatys-Bogacka

Mazurkiewicz

Słowik

et al. 2023

Neurol Neurochir Pol.

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“…The term "long COVID" defines the persistence of the clinical manifestations after the acute phase of the disease. One of these manifestations, cognitive decline, involves concentration difficulties, memory deficits, as well as receptive language, disorders and deficits involving the executive functions [11].…”

Section: Introductionmentioning

confidence: 99%

Cognitive Deficits in Patients Who Recovered from Critical Covid-19: Unexpected Results of Follow-Up Patients Running title: Cognitive deficits and COVID-19

Andrade¹

2022

CCRT

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Purpose: To identify the presence of cognitive sequelae in patients who underwent prolonged orotracheal intubation and who received a speech therapy assessment and rehabilitation during hospitalization due to COVID19. Methods: Participants of the study were 50 individuals, 24 females (43.55%) and 26 males (56.45%), with a mean age of 57.8 years (±14.35), who received treatment at Hospital das Clínicas of the School of Medicine of the University of São Paulo, Brazil (HCFMUSP) due to critical COVID-19. Demographic and clinical data were collected using Addenbrooke's Cognitive Examination - Revised Version (ACE-R) [1]. Results: Results indicated the presence of cognitive deficits in 75% of the participants for all of the tested skills. Conclusion: The results of the present study indicated the presence of cognitive deficits in all of the tested parameters. Future studies should include new analyzes correlating patient severity at hospital admission, demographic data and cognitive abilities.

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Post-COVID-19 syndrome and quality of life impairment in severe COVID-19 Mexican patients

Román-Montes,

Flores-Soto,

Guaracha-Basañez

et al. 2023

Front. Public Health

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IntroductionPost-COVID-19 syndrome (PCS) usually occurs 3 months after the onset of COVID-19 with a symptom duration of at least 2 months without an alternative diagnosis.ObjectiveThis study aimed to describe the prevalence, characteristics, and impact on the quality of life (QoL) of post-COVID-19 syndrome in patients with a history of hospitalization for COVID-19.Materials and methodsWe conducted a cross-sectional study. Patients who required hospitalization due to COVID-19 between March 2020 and October 2021 were invited to answer a PCS questionnaire and the EQ-5D instrument. A total of 246 patients were included: 187 (76%) met the definition of PCS and 54% were men, with a median age of 50 years (IQR 41–63).ResultsFrom 187 patients with PCS, the median time to symptom onset after hospital discharge was 1 day (IQR 1–20), and the median symptom duration was 150 days (IQR 90–225). A total of 27 different symptoms were reported; the most frequent were difficulty concentrating (81%), dyspnea (75%), arthralgia (71%), fatigue (68%), and hair loss (60%). Some symptoms, such as difficulty concentrating, arthralgia/myalgia, and hair loss, were more prevalent in women with PCS. Patients with PCS had a higher frequency of tobacco smoking (37 vs. 4%, p = 0.02) and increased severity of lung involvement in the initial chest tomography (75 vs. 58%, p = 0.01) than those without PCS. Patients with PCS were less likely to receive antivirals (15.5 vs. 27%, p = 0.04). No difference between ICU admission, mechanical ventilation, and length of hospital stay was found. Patients with PCS had a lower visual analog scale result for EQ-5D vs. those without (80 [IQR 70–90] vs. 89.5 [IQR 75–90], p = 0.05). All five QoL dimensions were affected in PCS patients, showing increased pain/discomfort (67 vs. 39%, p = < 0.001), difficulties in performing usual activities (39.2 vs. 20.3%, p = 0.03), and anxiety/depression (57.5 vs. 37%, p = 0.02).ConclusionPCS occurred in 76% of hospitalized patients with prolonged duration and QoL impairment. Neurological symptoms such as difficulty concentrating were the most frequent symptoms. Timely diagnostic and therapeutic interventions are required.

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Cognitive sequelae of COVID-19, a post-pandemic threat. Should we be worried about the brain fog?

Abstract: Cognitive sequelae of COVID-19, a post-pandemic threat. Should we be worried about the brain fog?Secuelas cognitivas del COVID-19, una amenaza post-pandemia. ¿Deberíamos estar preocupados por la niebla cerebral?

Cited by 3 publications

References 17 publications

Sex-related patient-reported brain fog symptoms in non-hospitalised COVID-19 patients

Sex-related patient-reported brain fog symptoms in non-hospitalised COVID-19 patients

Cognitive Deficits in Patients Who Recovered from Critical Covid-19: Unexpected Results of Follow-Up Patients Running title: Cognitive deficits and COVID-19

Post-COVID-19 syndrome and quality of life impairment in severe COVID-19 Mexican patients

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