Association of leptin levels with pathogenetic risk of coronary heart disease and stroke: a meta-analysis

Zeng, Rui; Xu, Chunhua; Xu, Yuanning; Wang, Yali; Wang, Mian

doi:10.1590/0004-2730000003390

Cited by 32 publications

(28 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, the association between high leptin concentration and risk of CVD is controversial. A published meta-analysis, comprising eight nested case-control studies with a total of 1980 CVD patients and 11567 participants, indicated a significant association between leptin and pathogenetic risk of CHD and stroke [21]. In contrast, the latest research studies did not find the same association [22–24].…”

Section: Introductionmentioning

confidence: 99%

Leptin concentration and risk of coronary heart disease and stroke: A systematic review and meta-analysis

Yang

Guo

et al. 2017

PLoS ONE

View full text Add to dashboard Cite

Background and purposeAlthough high leptin concentration has been shown to be correlated with established vascular risk factors, epidemiologic studies have reported inconclusive results on the association between leptin and cardiovascular diseases (CVD). Therefore, a meta-analysis was performed to evaluate this issue.MethodsWe searched Pubmed, Embase, and the Cochrane Library from their inception to Jan 2016 for both case-control and cohort studies that assessed leptin concentration and CVD risk. Reports with odds ratio (OR), risk ratio (RR) and corresponding 95% confidence intervals (CI) were considered. The data were extracted by two investigators independently.ResultsA total of 13 epidemiologic studies totaling 4257 CVD patients and 26710 controls were included. A significant inverse association was shown between leptin and coronary heart disease (CHD), with an overall OR of 1.16 (95% CI: 1.02–1.32), but not for stroke (OR = 1.21, 95% CI 0.98–1.48) under sociodemographic adjustment. Further adjustment for additional cardiovascular risk factors resulted in ORs of 1.16 (95% CI 0.97–1.40) for CHD and 1.10 (95% CI 0.89–1.35) for stroke. The findings remained when analyses were restricted to high-quality studies and indicated OR estimates of 1.07 (95% CI 0.96–1.19) for CHD and 0.98 (95% CI 0.76–1.25) for stroke. In a subgroup meta-analysis, a high leptin level was not independently associated with CHD in both females (OR = 1.03, 95% CI 0.86–1.23) and males (OR = 1.09, 95% CI 0.95–1.26) or with stroke in both females (OR = 1.13, 95% CI 0.87–1.47) and males (OR = 0.80, 95% CI 0.59–1.09). There was no significant publication bias as suggested by Egger test outcomes.ConclusionsOur findings indicate that high leptin levels may not be associated with risks of CHD and stroke. Further large, well-designed prospective cohort studies are needed to fully evaluate the role of leptin on the risk of CVD.

show abstract

Section: Introductionmentioning

confidence: 99%

Leptin concentration and risk of coronary heart disease and stroke: A systematic review and meta-analysis

Yang

Guo

et al. 2017

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…In hypertension, leptin induces endothelial nitric oxide synthase expression and vasodilation by the direct action of leptin on vascular endothelial cells [22]. However, the activation of sympathetic nerves increases blood pressure, and the net effect of leptin is the induction of arteriosclerosis [23, 24]. …”

Section: Introductionmentioning

confidence: 99%

Alamandine reduces leptin expression through the c-Src/p38 MAP kinase pathway in adipose tissue

et al. 2017

View full text Add to dashboard Cite

ObjectiveObesity is associated with an increased risk of diabetes mellitus, hypertension, and renal dysfunction. Angiotensin 1–7 and alamandine are heptameric renin angiotensin system peptide hormones. Further, alamandine levels increase with renal dysfunction. In the cardiovascular system, angiotensin 1–7 and alamandine produce similar improvements and counterbalance angiotensin II in regulating vascular function. We aimed to determine whether the effect of alamandine on leptin expression and secretion in adipocytes was similar to that of angiotensin 1–7.Approach and resultsWe studied isolated peri-renal visceral adipose tissue and peri-renal isolated visceral adipocytes from male Wistar rats. Angiotensin II from 0.01 to 10nM had no effect on leptin expression. Angiotensin 1–7 (1 nM) increased leptin secretion and expression, whereas alamandine (1 nM) decreased leptin secretion and expression in adipose tissue and isolated adipocytes and reduced blood leptin levels in vivo. These effects were mediated by Gq, c-Src, p38 mitogen-activated protein, and IκB activation. Additionally, alamandine induced nitric oxide expression via inducible nitric oxidase synthase and plasminogen activator inhibitor 1 expression in adipose tissue and isolated adipocytes.ConclusionsAngiotensin 1–7 and alamandine produced opposing effects on leptin expression and secretion in adipose tissue. This result suggests that the action of Mas (angiotensin 1–7 receptor) and Mas-related G-protein coupled receptor D in adipocytes exhibited opposing actions similar to angiotensin II type 1 and type 2 receptors.

show abstract

“…For example, hyperleptinemia and hypoadiponectinemia have been associated with an increase in fat tissue [2,3] and prediabetes [4], respectively. Additionally, a meta-analysis [5] reported a significant association between leptin and the risk of cardiovascular diseases (CVD; OR 1.90, 95% CI 1.06-3.43) and strokes (OR 2.14, 95% CI 1.48-3.08). Conversely, low adiponectin levels have been associated with increased cardiovascular events and mortality rates [6].…”

Section: Introductionmentioning

confidence: 99%

Association between Leptin, Adiponectin, and Leptin/Adiponectin Ratio with Clustered Metabolic Risk Factors in Portuguese Adolescents: The LabMed Physical Activity Study

Agostinis‐Sobrinho

Mendes²,

Moreira³

et al. 2017

Ann Nutr Metab

View full text Add to dashboard Cite

Introduction: Circulating leptin and adiponectin levels have been associated with impaired vascular function, insulin resistance, and acute cardiovascular evens. This study aimed to evaluate the associations of leptin, adiponectin, and the leptin/adiponectin (L/A) ratio with a clustering of metabolic risk factors (MRF) in adolescents aged 12-18 years. Methods: This is a cross-sectional analysis with 529 Portuguese adolescents aged 12-18 years. Blood samples were taken to analyze total cholesterol (TC) and high-density lipoprotein (HDL) cholesterol (HDL-c), triglycerides glucose, insulin, leptin, and adiponectin levels. A continuous variable of clustered MRF score (sum of Z-scores of body fat percentage, systolic blood pressure, ratio TC/HDL, triglycerides, homeostatic model assessment insulin resistance, and cardiorespiratory fitness*[-1]) was computed. Results: Regression analyses showed that adiponectin was a significant and negative predictor of MRF score (boys: β = -0.199; p < 0.001; girls: β = -0.200; p < 0.001); whereas leptin was a significant positive predictor of MRF score (boys: β = 0.553; p < 0.001; girls: β = 0.399; p < 0.001). The L/A ratio was also a significant positive predictor of MRF score in both sexes (boys: β = 0.593; p < 0.001; girls: β = 0.461; p < 0.001), after adjustments for age, pubertal stage, adherence to the Mediterranean diet, and socioeconomic status. In addition, adiponectin, leptin, and L/A ratio were accurate to predict MRF among adolescents, but L/A ratio showed the highest area under receiver operating characteristic curve. Conclusion: Leptin, adiponectin, and L/A ratio are associated with the clustering of MRF in adolescents after adjustments for age, sex, pubertal stage, adherence to the Mediterranean diet, and socioeconomic status. L/A ratio was more strongly associated with MRF score than adiponectin or leptin.

show abstract

Association of leptin levels with pathogenetic risk of coronary heart disease and stroke: a meta-analysis

Cited by 32 publications

References 26 publications

Leptin concentration and risk of coronary heart disease and stroke: A systematic review and meta-analysis

Leptin concentration and risk of coronary heart disease and stroke: A systematic review and meta-analysis

Alamandine reduces leptin expression through the c-Src/p38 MAP kinase pathway in adipose tissue

Association between Leptin, Adiponectin, and Leptin/Adiponectin Ratio with Clustered Metabolic Risk Factors in Portuguese Adolescents: The LabMed Physical Activity Study

Contact Info

Product

Resources

About