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Recognizing the importance of magnetic thin wires for science and technology, the 6th International Workshop on Magnetic Wires was held on 6–7 July 2010, in Bodrum, Turkey. A wide range of topics were addressed from technological problems of micro‐ and nanowire fabrication, to advanced physical effects and novel applications. Furthermore, critical discussions on the present state of knowledge and future trends arose during the Panel Session on microwires. In the present report, the main aspects addressed at the Discussion Panel and at workshop presentations are summarized with the aim to state the present and future perspectives on these wire systems. This report is focused upon four topics chosen for broad discussions at the Panel: Fabrication and processing, Magnetization reversal and Dynamics, High‐frequency properties, and Technological applications.

The study suggests that reduced levels of CSF alpha-synuclein in DLB may reflect the accumulation of alpha-synuclein with Lewy pathology in the brain and that quantification of CSF alpha-synuclein helps in the differentiation of DLB from AD and other dementias in combination with Abeta42 and tau analysis.

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We analyzed and organized the reasons why the amorphous wire CMOS IC magneto-impedance sensor (MI sensor) has rapidly been mass-produced as the electronic compass chips for the smart phones, mobile phones, and the wrist watches. Comprehensive advantageous features regarding six terms of (1) microsizing and ultralow power consumption, (2) high linearity without any hysteresis for the magnetic field detection, (3) high sensitivity for magnetic field detection with a Pico-Tesla resolution, (4) quick response for detection of magnetic field, (5) high temperature stability, and (6) high reversibility against large disturbance magnetic field shock are based on the magneto-impedance effect in the amorphous wires. We have detected the biomagnetic field using the Pico-Tesla resolution MI sensor at the room temperature such as the magneto-cardiogram (MCG), the magneto-encephalogram (MEG), and the self-oscillatory magnetic field of guinea-pig stomach smooth muscles (in vitro) that suggest the origin of the biomagnetic field is probably pulsive flow of Ca2+through the muscle cell membrane.

rylation may be partly attributable to IICR.Many cellular responses to diverse biological stimuli, such as neurotransmitters, hormones, and growth factors, are mediated by the intracellular second messenger inositol 1,4,5-trisphosphate (IP 3 ).1 IP 3 subsequently induces Ca 2ϩ mobilization from intracellular stores by activating its receptor (IP 3 R) (1, 2). IP 3 R channels form homo-or heterotetramers via the co-assembly of distinct types of IP 3 R subunits (types 1-3) (3) and bind IP 3 in a stoichiometric manner (4 3 R1) is composed of 2749 amino acids (molecular mass about 313 kDa) and is structurally divided into three parts as follows: a large N-terminal cytoplasmic arm region (83% of the receptor molecule); a putative six membrane-spanning region clustered near the C terminus, which is thought to constitute an ion channel by forming a tetramer; and a short C-terminal cytoplasmic tail region (6). In our previous studies (7, 8) on the ligand-binding site of mouse type 1 IP 3 R (mIP 3 R1), we found that the core region, essential for the high affinity of ligand binding, was localized in amino acid residues 226 -576. We also found that the affinity of residues 1-604 (T604) of mIP 3 R1 for IP 3 (K d ϭ 45 nM) was comparable with that of the native cerebellar IP 3 R (83 nM) (4), indicating that T604 could form a well folded or compact conformation for the functional IP 3 -binding pocket (7, 9). The N-terminal residues 1-223, which we assigned as a suppresser region, instead of being directly responsible for IP 3 binding, suppressed the binding activity of the core region (7, 9). Without the putative suppresser region, residues 224 -604 showed markedly higher affinity for IP 3 than did the parental T604 (7). We therefore inferred that such a high affinity IP 3 -binding protein could function as an IP 3 absorbent in living cells and compete with the native IP 3 R for binding to IP 3 .In this paper, we report the development of a novel recombinant IP 3 absorbent, the "IP 3 sponge," which has hyperaffinity for IP 3 (K d ϭ 0.092 nM). The IP 3 sponge was constructed on the basis of the ligand-binding site of mIP 3 R1, and we assumed that this hyperaffinity IP 3 sponge could compete with IP 3 R for the IP 3 signal. We showed that its application actually caused specific inhibition of in vitro IICR in a dose-dependent manner. Moreover, the IP 3 sponge exogenously expressed in HEK293 cells could trap IP 3 produced in response to stimulation with either carbachol (CCh) or ATP, resulting in inhibition of IICR. The IP 3 sponge appeared to be effective in competing for IP 3 with multiple types of tetrameric IP 3 R channels, because HEK293 cells expressed all three IP 3 R subunits (10). The effectiveness of the IP 3 sponge on IP 3 -Ca 2ϩ signaling-dependent cell physiology was verified by providing an invaluable insight into the functional role of IICR in the phosphorylation of cAMPresponse element-binding protein (CREB), which was previously thought to be activated mainly by Ca 2ϩ influx (11,12). EXPERIMENTAL PROCEDURESConst...