“…In addition, high expression of HSD17B1 is associated with deviated follicular fluid steroid levels in polycystic ovarian syndrome (Yu et al, 2021), foetal growth restriction (Zhu et al, 2018), chronic obstructive pulmonary disease (COPD; (Konings et al, 2017); and other disorders including lung cancer, skin and eye diseases (Konings et al, 2018a;Heinosalo et al, 2019). Additionally, genetic variants in the HSD17B1 gene are associated with amyotrophic lateral sclerosis (Boddy et al, 2022), endometriosis associated infertility (Egashira et al, 2022) and other disorders (Konings et al, 2018b). Animal studies as well point out that expression of HSD17B1 leads to endometrial hyperplasia (Saloniemi et al, 2010), endometrial cancer (Konings et al, 2018b;Xanthoulea et al, 2021), adenomyosis (Heinosalo et al, 2022), and mammary gland pathologies (Jarvensivu et al, 2018).…”