Determination of antimicrobial and antimutagenic properties of some Schiff bases

Öğütçü, Hatice; Meral, Seher; Çeker, Selçuk; Ağar, Ayşen Alaman; Ağar, Güleray

doi:10.1590/0001-3765202120191432

Cited by 3 publications

(2 citation statements)

References 15 publications

(7 reference statements)

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“…[10] For example, the antimutagenic activities of some derivatives of thiosemicarbazones, dihydropyridines, and Schiff bases have already been scientifically proven. [11][12][13] Genotoxicology includes the development of various test systems for the elucidation of mutagenic effects, and the detection of mutagenic substances as well as the investigations carried out to reduce the risk of hereditary diseases, and cancer through mutagenesis in humans. The Ames test developed by Bruce Ames in the 1970s, [14] which is used as the first screening step to determine the in vitro mutagenic effect of chemical substances, is used reliably worldwide as a short-term bacterial test.…”

Section: Introductionmentioning

confidence: 99%

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In Vitro Genotoxic and Antigenotoxic Effects of Ten Novel Synthesized 4‐Thiazolidinone Derivatives

Alaylar,

Güllüce,

Turhan

et al. 2023

Chemistry & Biodiversity

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Heterocyclic compounds are found in a variety of drug molecules, and bioactive natural products. 4‐Thiazolidinones (4‐TZDs), which represent an important class of heterocyclic compounds, are of great interest today with their diverse bioactivities. In this study, ten novel 4‐TZD derivatives (C1–C10) were synthesized, characterized by spectroscopic techniques, and their genotoxic, and antigenotoxic properties were investigated in vitro using the Ames Salmonella/microsome mutagenicity assay in the concentration range of 0.2–1.0 mM/plate. The results revealed that none of the compounds were mutagenic on the three different Salmonella typhimurium strains up to the highest concentration tested. Furthermore, in our study, C1, C4, C6, and C9 showed significant, ranging from moderate to strong, antigenotoxic effects against mutagen‐induced DNA damage at relatively higher doses. Among these, C4 had the best potential to inhibit the number of revertant colonies induced by 9‐aminoacridine (9‐AA), with a maximum inhibition rate of 47.9 % for 1.0 mM/plate. As a result, preliminary knowledge about the safety of the use of ten novel synthesized 4‐TZD compounds likely to exhibit many bioactivities was obtained in this study. In addition, the significant in vitro antimutagenic activity of some derivatives increases the importance of studies for the development of new pharmacological agents for cancer prevention.

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Section: Introductionmentioning

confidence: 99%

“…In the last ten years, there has been a trend towards the use of synthetic drugs in antimutagenicity studies [10] . For example, the antimutagenic activities of some derivatives of thiosemicarbazones, dihydropyridines, and Schiff bases have already been scientifically proven [11–13] …”

Section: Introductionmentioning

confidence: 99%