Chitosan gels for buccal delivery of Schinus molle L. essential oil in dogs: characterization and antimicrobial activity in vitro

Alves, Melina Cardilo Campos; Chaves, Douglas Siqueira de Almeida; Benevenuto, Byanca Ribeiro; Farias, Beatriz Oliveira; Coelho, S.M.O.; Ferreira, Thaís Paes; Pereira, Geraldo Augusto; Santos, Gabriela Carmelinda Martins dos; Moreira, Leandra Oliveira; Freitas, Juliana Pereira de; Cid, Yara Peluso

doi:10.1590/0001-3765202020200562

Cited by 7 publications

(3 citation statements)

References 21 publications

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“…Prepared hydrogels were then mixed with AgNPs (1% w/w), triethanolamine 0.2% v/w dimethyl sulfoxide 1% v/w, and methylparaben 0.02% w/w. AgNPs loaded chitosan-based gels (AgNPs-CBG) was then mixed with a digitally controlled overhead mixer for overnight to complete the homogenization using a mechanical homogenizer (T-18 Ultra-Turrax, IKA Ltd., Staufen, Germany) [27][28][29].…”

Section: Development Of Agnps Loaded Chitosan-based Topical Gelsmentioning

confidence: 99%

“…In this test, the AgNPs loaded chitosan chitosan-based gels (1 gm) subjected to freezing and thawing 2 days' cycles at 45 • C (Hot) and 4 • C (Cold). Besides, centrifugal testing was performed by taking the sample (1 gm) in Eppendorf tube, kept it in the rotor sample holder, centrifuged at 3000 rpm for 30 min at 6 • C, and observed for sediment in the bottom [28].…”

Section: Ph Testmentioning

confidence: 99%

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Green Synthesized Silver Nanoparticles Using Tridax Procumbens for Topical Application: Excision Wound Model and Histopathological Studies

et al. 2021

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The objective of this study was to synthesize silver nanoparticles from the leaves of Tridax procumbens and develop its topical gels using chitosan to investigate the wound healing efficacy concomitant with the histopathological study. Green synthesized silver nanoparticles (AgNPs) were prepared by reacting silver nitrate (0.3 M) with leaf extract and characterized by particle analysis, FTIR, XRD, SEM, BET, and TGA. The results revealed formed AgNPs were nano-sized (138 ± 2.1 nm), monodispersed (PDI: 0.460 ± 0.3), inter-particle repulsion (zeta: −20.4 ± 5.20 mV), stabilized, crystalline and, spherical with size ranging from 80–100 nm as per SEM micro photos. The BET analysis of AgNPs presents the surface area (12.861 m2/g), pore volume (0.037 cc/g), and pore radius (24.50 nm).TGA results show a loss of 13.39% up to 300 °C. The topical formulation was developed by loading AgNPs in chitosan-based gels, evaluated by pH, thermal cycling, centrifugal, and spreadability tests. AgNPs chitosan gels results showed skin compatibility, higher stability, and spreading ability. The maximum antibacterial zone of inhibition was found to be 25 ± 0.98 mm for bacillus subtitles and 30 ± 1.99 mm for Klebsiella pneumoniae, respectively. Nanosilver-containing gel also showed excellent compatibility with erythrocytes. Excision wound model was used to assess the wound healing property of the developed AgNP gels, the results of which indicated a significantly progressive healing process in test-group of animals treated with chitosan-based gels containing AgNPs. A histopathological study further confirmed the almost normal skin structure of treated animal tissue compared to standard and negative control. Thus, green synthesized AgNPs loaded chitosan-based topical gel can potentially be used for wound healing application.

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Section: Development Of Agnps Loaded Chitosan-based Topical Gelsmentioning

confidence: 99%

Section: Ph Testmentioning

confidence: 99%

Green Synthesized Silver Nanoparticles Using Tridax Procumbens for Topical Application: Excision Wound Model and Histopathological Studies

et al. 2021

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“…CS gels loaded with Schinus molle L. essential oil were evaluated for activity against bacteria associated with periodontal disease in dogs [ 25 ]. These gels showed their potential as a delivery system for Schinus molle L. and presented ideal physicochemical and rheological properties required for application on buccal tissue, such as good stability and antimicrobial activity against Gram-positive and Gram-negative bacteria ( Staphylococcus spp., Streptococcus, Corynebacterium spp., Pseudomonas spp.)…”

Section: Polymer–drug Systemsmentioning

confidence: 99%

Polysaccharide-Based Drug Delivery Systems for the Treatment of Periodontitis

et al. 2021

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Periodontal diseases are worldwide health problems that negatively affect the lifestyle of many people. The long-term effect of the classical treatments, including the mechanical removal of bacterial plaque, is not effective enough, causing the scientific world to find other alternatives. Polymer–drug systems, which have different forms of presentation, chosen depending on the nature of the disease, the mode of administration, the type of polymer used, etc., have become very promising. Hydrogels, for example (in the form of films, micro-/nanoparticles, implants, inserts, etc.), contain the drug included, encapsulated, or adsorbed on the surface. Biologically active compounds can also be associated directly with the polymer chains by covalent or ionic binding (polymer–drug conjugates). Not just any polymer can be used as a support for drug combination due to the constraints imposed by the fact that the system works inside the body. Biopolymers, especially polysaccharides and their derivatives and to a lesser extent proteins, are preferred for this purpose. This paper aims to review in detail the biopolymer–drug systems that have emerged in the last decade as alternatives to the classical treatment of periodontal disease.

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Effects of dietary supplementation with a blend of functional oils to fecal microbiota, and inflammatory and oxidative responses, of dogs submitted to a periodontal surgical challenge

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Bastos

et al. 2023

Animal Feed Science and Technology

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Chitosan gels for buccal delivery of Schinus molle L. essential oil in dogs: characterization and antimicrobial activity in vitro

Cited by 7 publications

References 21 publications

Green Synthesized Silver Nanoparticles Using Tridax Procumbens for Topical Application: Excision Wound Model and Histopathological Studies

Green Synthesized Silver Nanoparticles Using Tridax Procumbens for Topical Application: Excision Wound Model and Histopathological Studies

Polysaccharide-Based Drug Delivery Systems for the Treatment of Periodontitis

Effects of dietary supplementation with a blend of functional oils to fecal microbiota, and inflammatory and oxidative responses, of dogs submitted to a periodontal surgical challenge

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