Relationship between the hsa miR 150-5p and FTO gene expression in white subcutaneous adipose tissue with overweight/obesity, lipid profile and glycemia

Abstract

The overweight population is growing in the world, and the search for obesityassociated mechanisms is important for a better understanding of this disease. Few studies with the FTO gene and miRs show how they associate to obesity and how they can impact this disease. The aim of this study was to verify the relationship between the FTO gene and the hsa-miR-150-5p expression with overweight/obesity, lipid profi le, and fast blood glucose. Men and women (18 years older or above), with body mass index ≥ 18.5 kg/m 2 , were enrolled in the present study and the FTO gene and hsa-miR-150-5p expression, biochemical parameters of blood and anthropometric measurements were analyzed. The results highlight that the FTO gene expression is associated to obesity (p 0.029), LDL-C (p 0.02) and fasting blood glucose (p 0.02), but not with triglycerides (p 0.69), total cholesterol (p 0.21), and HDL-C (p 0.24). The hsa-miR-150-5p is not associated to obesity (p 0.84), triglycerides (p 0.57), total cholesterol (p 0.51), HDL-C (p 0.75), LDL-C (p 0.32), and fasting blood glucose (p 0.42). The FTO gene expression is related to obesity, LDL-C and blood fasting glucose, representing a good molecular marker for obesity.

The association between FTO rs9939609 polymorphism and serum lipid profile in adult women

“…Another study in Pakistan also found no association between the lipid profile parameters and rs9939609 polymorphism of FTO gene [ 32 ]. Morae s et al reported FTO gene is associated with LDL but not with HDL cholesterol in obese people that can imply a possible role for obesity in the association between FTO genotype and lipid profile [ 33 ]. HDL-c level is known to be associated with metabolic diseases.…”

Unique genetic variants of lean nonalcoholic fatty liver disease: a retrospective cohort study

“…A case–control analysis study of 612 Pakistani subjects found that the interaction between the CT genotype of rs1421085 and overweight/obesity affects TG and LDL independent of age and sex [ 50 ]. From another report, FTO gene expression was shown to be associated with LDL, and fasting glucose, but not TG, TC, and HDL [ 51 ]. We are also interested in an investigation of the association of the FTO rs9939609 polymorphism with lipid profiles in Iranian women, who noted that lower levels of HDL were observed in the AT/AA genotype compared to the TT wild-type genotype of the FTO rs9939609 polymorphism, with adjustments for age, BMI and physical activity that did not alter the results [ 52 ].…”