Transdermal patches of lidocaine/aspirin ionic liquid drug-loaded gelatin/polyvinyl alcohol composite film prepared by freeze-thawed procedure

Maneewattanapinyo, Pattwat; Yeesamun, Alisa; Watthana, Fueangfah; Panrat, Kamon; Pichayakorn, Wiwat; Suksaeree, Jirapornchai

doi:10.1590/0001-3765202020191073

Cited by 10 publications

(7 citation statements)

References 34 publications

(23 reference statements)

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“…The biological activity of the scaffolds is related to the crystal structure of the organic components. Based on XRD analysis, the results verified that the ordered arrangement of the original molecular chains and oxygen functional groups of PVA and aspirin changed, so their crystalline state disappeared in hydrogel scaffolds ( Zhang et al, 2019 ; Maneewattanapinyo et al, 2020 ). The crystalline structure of nano-hydroxyapatite was not affected, which in favour to improve the mechanical strength of the hydrogel scaffold.…”

Section: Discussionmentioning

confidence: 81%

Osteogenic and anti-inflammatory effect of the multifunctional bionic hydrogel scaffold loaded with aspirin and nano-hydroxyapatite

Xiaowen

Yang

et al. 2023

Front. Bioeng. Biotechnol.

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Although tissue engineering offered new approaches to repair bone defects, it remains a great challenge to create a bone-friendly microenvironment and rebuild bone tissue rapidly by a scaffold with a bionic structure. In this study, a multifunctional structurally optimized hydrogel scaffold was designed by integrating polyvinyl alcohol (PVA), gelatin (Gel), and sodium alginate (SA) with aspirin (ASA) and nano-hydroxyapatite (nHAP). The fabrication procedure is through a dual-crosslinking process. The chemical constitution, crystal structure, microstructure, porosity, mechanical strength, swelling and degradation property, and drug-release behavior of the hydrogel scaffold were analyzed. Multi-hydrogen bonds, electrostatic interactions, and strong “egg-shell” structure contributed to the multi-network microstructure, bone tissue-matched properties, and desirable drug-release function of the hydrogel scaffold. The excellent performance in improving cell viability, promoting cell osteogenic differentiation, and regulating the inflammatory microenvironment of the prepared hydrogel scaffold was verified using mouse pre-osteoblasts (MC3T3-E1) cells. And the synergistic osteogenic and anti-inflammatory functions of aspirin and nano-hydroxyapatite were also verified. This study provided valuable insights into the design, fabrication, and biological potential of multifunctional bone tissue engineering materials with the premise of constructing a bone-friendly microenvironment.

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Section: Discussionmentioning

confidence: 81%

Osteogenic and anti-inflammatory effect of the multifunctional bionic hydrogel scaffold loaded with aspirin and nano-hydroxyapatite

Xiaowen

Yang

et al. 2023

Front. Bioeng. Biotechnol.

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“…The thermal characterization of solvent-cast polymeric lms containing ionic liquid lidocaine/aspirin for transdermal patches is shown in Figure 2; the thermal characterization of lidocaine, aspirin, and ionic liquid lidocaine/aspirin are known from previous studies (25,26). Brie y, from Figure 2A, the melting point of lidocaine, aspirin, and ionic liquid lidocaine/aspirin were 77.75°C, 141°C, and 93.50°C, respectively.…”

Section: Resultsmentioning

confidence: 82%

“…The preparation and characterization of ionic liquid drug of combined lidocaine and aspirin were reported previously by our research group (25,26). In the present research, the prepared ionic liquid lidocaine/aspirin was loaded into the solvent-cast polymeric lm for transdermal patches.…”

Section: Resultsmentioning

confidence: 86%

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Solvent‐Cast Polymeric Films from Pectin and Eudragit® NE 30D for Transdermal Drug Delivery Systems

et al. 2021

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In this study, solvent-cast polymeric lms containing ionic liquid lidocaine/aspirin for transdermal patches were developed. Solvent-cast polymeric lms were prepared from two polymers, pectin and Eudragit ® NE 30D, by drying the polymeric solution in a hot air oven at 70 ± 3°C for 10 hrs. Glycerin was used as a plasticizer. Lidocaine and aspirin were prepared in ionic liquid form and loaded into the patches. The physicomechanical properties of the lms were characterized by texture analysis, differential scanning calorimetry, thermogravimetric analysis, and X-ray diffraction. A scanning electron microscope was used to photograph the surfaces of solvent-cast polymeric lms. Eudragit ® NE 30D signi cantly decreased the toughness and rigidity of the lms. The transdermal patches were in the amorphous state, and their thermal properties were not changed from blank polymeric lms. The surfaces of transdermal patches were rougher than blank polymeric lms and revealed the distribution of the drug. Eudragit ® NE 30D signi cantly decreased the trends of entrapment e ciency and in vitro release of lidocaine and aspirin drugs. The kinetic release observed in vitro tted to Higuchi's model rather than zero and rst order models, indicating that a diffusion mechanism governed the release of the drug from the patch. Thus, the solvent-cast polymeric lms from two polymers, pectin and Eudragit ® NE 30D, are suitable for transdermal patches loaded with ionic liquid lidocaine/aspirin.

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“…Maneewattapinyio et al produced a transdermal patch composed of lidocaine-aspirin IL, poly(vinyl alcohol), and gelatin, using a freeze-thawed procedure, which can control the release of the active molecules. 89 Nevertheless, it should be kept at a low temperature (4 °C) to protect it and avoid reducing the amount of drug released.…”

Section: Ramin Et Al Used An Il 1-methylimidazolium Hydrogen Sulfate ...mentioning

confidence: 99%

Green Solvents Combined with Bioactive Compounds as Delivery Systems: Present Status and Future Trends

Silva

Gomes

Reis

et al. 2021

ACS Appl. Bio Mater.

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Green solvents such as ionic liquids (ILs) unlock possibilities for developing innovative biomedical and pharmaceutical solutions. ILs are the most investigated solvents for compound extractions, as reaction media and/or catalysts, and a desired eco-friendly solvent to process biomacromolecules for biomaterial production. Investigations demonstrate that the tunable nature and physicochemical features of ILs are also beneficial for building up delivery systems through their combination with bioactive compounds. Bioactive compounds from synthetic origins, like ibuprofen, ketoprofen, and natural sources such as curcumin, flavonoids, and polyphenols are essential starting points as preventive and therapeutic agents for treating diseases. Therefore, the association of those compounds with ILs opens up windows of opportunities in this research field. This Review assesses some of the main and important recent information and the current challenges concerning delivery platforms based on ILs combined with bioactive compounds of both natural and synthetic origins. Moreover, the chemistry, bioavailability, and biological functions of the main bioactive compounds used in the ILs-based delivery platforms are described. These data are presented and are discussed, together with the main delivery routes of the systems.

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Transdermal patches of lidocaine/aspirin ionic liquid drug-loaded gelatin/polyvinyl alcohol composite film prepared by freeze-thawed procedure

Cited by 10 publications

References 34 publications

Osteogenic and anti-inflammatory effect of the multifunctional bionic hydrogel scaffold loaded with aspirin and nano-hydroxyapatite

Osteogenic and anti-inflammatory effect of the multifunctional bionic hydrogel scaffold loaded with aspirin and nano-hydroxyapatite

Solvent‐Cast Polymeric Films from Pectin and Eudragit® NE 30D for Transdermal Drug Delivery Systems

Green Solvents Combined with Bioactive Compounds as Delivery Systems: Present Status and Future Trends

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